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Differential white cell count after two bouts of downhill running.
Int J Sports Med. 1998 Aug; 19(6):432-7.IJ

Abstract

The purpose of this study was to compare blood markers associated with eccentrically biased exercise and muscle damage, after two bouts of downhill running. Nine active, untrained males performed 2 x 45 min bouts of downhill running (-0.16 radians), at a speed that would elicit 70% of each subjects VO2max, on a level grade; runs were spaced 14d apart (RUN1, RUN2). Blood samples were obtained before, after, and every hour for 12 h after exercise, as well as every 24 h for 5 d, to assess numbers of circulating neutrophils, monocytes, and lymphocytes, serum cortisol, creatine kinase (CK); subjective sensations of delayed onset muscle soreness (DOMS) were monitored. To control for diurnal variation, two weeks prior to the RUN1, subjects had blood draws performed at the same time as would occur after exercise, but did no exercise (CONTROL). During the 5 d after exercise, DOMS and CK were significantly greater (p < 0.05) after RUN1 compared to RUN2 and CONTROL. During the 12 h after RUN1 and RUN2, neutrophils showed similar responses compared to CONTROL. However, neutrophils were significantly elevated at 96 h after RUN1 and 24 h after RUN2. Monocytes were significantly elevated during 5-11 h after RUN1 and RUN2, compared to CONTROL. Cortisol showed a similar significant diurnal decrease for all three conditions during the 12 h following exercise. The significantly lower levels of CK and DOMS seen after RUN2, compared with the initial run is consistent with the literature. The similar changes in neutrophils and monocytes during the 12 h following RUN1 and RUN2, followed by disparate responses over the subsequent 5 d, requires further investigation.

Authors+Show Affiliations

Human Performance Laboratory, Appalachian State University, Boone, NC 28608, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9774212

Citation

Smith, L L., et al. "Differential White Cell Count After Two Bouts of Downhill Running." International Journal of Sports Medicine, vol. 19, no. 6, 1998, pp. 432-7.
Smith LL, Bond JA, Holbert D, et al. Differential white cell count after two bouts of downhill running. Int J Sports Med. 1998;19(6):432-7.
Smith, L. L., Bond, J. A., Holbert, D., Houmard, J. A., Israel, R. G., McCammon, M. R., & Smith, S. S. (1998). Differential white cell count after two bouts of downhill running. International Journal of Sports Medicine, 19(6), 432-7.
Smith LL, et al. Differential White Cell Count After Two Bouts of Downhill Running. Int J Sports Med. 1998;19(6):432-7. PubMed PMID: 9774212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential white cell count after two bouts of downhill running. AU - Smith,L L, AU - Bond,J A, AU - Holbert,D, AU - Houmard,J A, AU - Israel,R G, AU - McCammon,M R, AU - Smith,S S, PY - 1998/10/17/pubmed PY - 1998/10/17/medline PY - 1998/10/17/entrez SP - 432 EP - 7 JF - International journal of sports medicine JO - Int J Sports Med VL - 19 IS - 6 N2 - The purpose of this study was to compare blood markers associated with eccentrically biased exercise and muscle damage, after two bouts of downhill running. Nine active, untrained males performed 2 x 45 min bouts of downhill running (-0.16 radians), at a speed that would elicit 70% of each subjects VO2max, on a level grade; runs were spaced 14d apart (RUN1, RUN2). Blood samples were obtained before, after, and every hour for 12 h after exercise, as well as every 24 h for 5 d, to assess numbers of circulating neutrophils, monocytes, and lymphocytes, serum cortisol, creatine kinase (CK); subjective sensations of delayed onset muscle soreness (DOMS) were monitored. To control for diurnal variation, two weeks prior to the RUN1, subjects had blood draws performed at the same time as would occur after exercise, but did no exercise (CONTROL). During the 5 d after exercise, DOMS and CK were significantly greater (p < 0.05) after RUN1 compared to RUN2 and CONTROL. During the 12 h after RUN1 and RUN2, neutrophils showed similar responses compared to CONTROL. However, neutrophils were significantly elevated at 96 h after RUN1 and 24 h after RUN2. Monocytes were significantly elevated during 5-11 h after RUN1 and RUN2, compared to CONTROL. Cortisol showed a similar significant diurnal decrease for all three conditions during the 12 h following exercise. The significantly lower levels of CK and DOMS seen after RUN2, compared with the initial run is consistent with the literature. The similar changes in neutrophils and monocytes during the 12 h following RUN1 and RUN2, followed by disparate responses over the subsequent 5 d, requires further investigation. SN - 0172-4622 UR - https://wwww.unboundmedicine.com/medline/citation/9774212/Differential_white_cell_count_after_two_bouts_of_downhill_running_ DB - PRIME DP - Unbound Medicine ER -