Tags

Type your tag names separated by a space and hit enter

A gene for autosomal dominant hypohidrotic ectodermal dysplasia (EDA3) maps to chromosome 2q11-q13.
Am J Hum Genet. 1998 May; 62(5):1102-6.AJ

Abstract

Autosomal dominant hypohidrotic ectodermal dysplasia (ADHED) is a disorder characterized by fine, slow-growing scalp and body hair, sparse eyebrows and eyelashes, decreased sweating, hypodontia, and nail anomalies. By genetic linkage analysis of a large ADHED kindred, we have mapped a gene for ADHED (EDA3) to the proximal long arm of chromosome 2 (q11-q13). Obligate recombinations localize EDA3 to an approximately 9-cM interval between D2S1321 and D2S308, with no apparent recombinations with markers D2S1343, D2S436, D2S293, D2S1894, D2S1784, D2S1890, D2S274, and CHLC.GAAT11C03.

Links

PMC Free PDF
PMC Free Full Text
Publisher Full Text
linkinghub.elsevier.com
linkinghub.elsevier.com

Authors+Show Affiliations

Ho L
Department of Medical Genetics, University of Wisconsin, Madison, WI 53706, USA.
Williams MS
No affiliation info available
Spritz RA
No affiliation info available

MeSH

Chromosomes, Human, Pair 2Ectodermal DysplasiaEctodysplasinsFemaleGenes, DominantGenetic LinkageHumansHypohidrosisMaleMembrane ProteinsPedigree

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9545409

Citation

Ho, L, et al. "A Gene for Autosomal Dominant Hypohidrotic Ectodermal Dysplasia (EDA3) Maps to Chromosome 2q11-q13." American Journal of Human Genetics, vol. 62, no. 5, 1998, pp. 1102-6.
Ho L, Williams MS, Spritz RA. A gene for autosomal dominant hypohidrotic ectodermal dysplasia (EDA3) maps to chromosome 2q11-q13. Am J Hum Genet. 1998;62(5):1102-6.
Ho, L., Williams, M. S., & Spritz, R. A. (1998). A gene for autosomal dominant hypohidrotic ectodermal dysplasia (EDA3) maps to chromosome 2q11-q13. American Journal of Human Genetics, 62(5), 1102-6.
Ho L, Williams MS, Spritz RA. A Gene for Autosomal Dominant Hypohidrotic Ectodermal Dysplasia (EDA3) Maps to Chromosome 2q11-q13. Am J Hum Genet. 1998;62(5):1102-6. PubMed PMID: 9545409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A gene for autosomal dominant hypohidrotic ectodermal dysplasia (EDA3) maps to chromosome 2q11-q13. AU - Ho,L, AU - Williams,M S, AU - Spritz,R A, PY - 1998/5/23/pubmed PY - 2000/3/21/medline PY - 1998/5/23/entrez SP - 1102 EP - 6 JF - American journal of human genetics JO - Am J Hum Genet VL - 62 IS - 5 N2 - Autosomal dominant hypohidrotic ectodermal dysplasia (ADHED) is a disorder characterized by fine, slow-growing scalp and body hair, sparse eyebrows and eyelashes, decreased sweating, hypodontia, and nail anomalies. By genetic linkage analysis of a large ADHED kindred, we have mapped a gene for ADHED (EDA3) to the proximal long arm of chromosome 2 (q11-q13). Obligate recombinations localize EDA3 to an approximately 9-cM interval between D2S1321 and D2S308, with no apparent recombinations with markers D2S1343, D2S436, D2S293, D2S1894, D2S1784, D2S1890, D2S274, and CHLC.GAAT11C03. SN - 0002-9297 UR - https://wwww.unboundmedicine.com/medline/citation/9545409/A_gene_for_autosomal_dominant_hypohidrotic_ectodermal_dysplasia__EDA3__maps_to_chromosome_2q11_q13_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9297(07)61531-6 DB - PRIME DP - Unbound Medicine ER -