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The molecular basis of keloid and hypertrophic scar formation.
Mol Med Today. 1998 Jan; 4(1):19-24.MM

Abstract

Excess scar formation secondary to traumatic or surgical injuries can have devastating consequences, ranging from body disfigurement to organ dysfunction. Hypertrophic scars and keloids are skin fibrotic conditions that can be caused by minor insults to skin, such as acne or ear piercing, or by severe injuries such as burns. Differences between keloids, hypertrophic scars and normal scars include distinct scar appearance, histologic morphology and cellular function in response to growth factors. Recent advances in our understanding of the wound healing process reveal possible causes for hypertrophic scars and keloids. This information might assist in the development of efficacious treatment for hypertrophic scar and keloid formation.

Authors+Show Affiliations

Department of Surgery, Children's Hospital Los Angeles, University of Southern California School of Medicine 90027, USA. ttuan@chlais.usc.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

9494966

Citation

Tuan, T L., and L S. Nichter. "The Molecular Basis of Keloid and Hypertrophic Scar Formation." Molecular Medicine Today, vol. 4, no. 1, 1998, pp. 19-24.
Tuan TL, Nichter LS. The molecular basis of keloid and hypertrophic scar formation. Mol Med Today. 1998;4(1):19-24.
Tuan, T. L., & Nichter, L. S. (1998). The molecular basis of keloid and hypertrophic scar formation. Molecular Medicine Today, 4(1), 19-24.
Tuan TL, Nichter LS. The Molecular Basis of Keloid and Hypertrophic Scar Formation. Mol Med Today. 1998;4(1):19-24. PubMed PMID: 9494966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The molecular basis of keloid and hypertrophic scar formation. AU - Tuan,T L, AU - Nichter,L S, PY - 1998/3/12/pubmed PY - 1998/3/12/medline PY - 1998/3/12/entrez SP - 19 EP - 24 JF - Molecular medicine today JO - Mol Med Today VL - 4 IS - 1 N2 - Excess scar formation secondary to traumatic or surgical injuries can have devastating consequences, ranging from body disfigurement to organ dysfunction. Hypertrophic scars and keloids are skin fibrotic conditions that can be caused by minor insults to skin, such as acne or ear piercing, or by severe injuries such as burns. Differences between keloids, hypertrophic scars and normal scars include distinct scar appearance, histologic morphology and cellular function in response to growth factors. Recent advances in our understanding of the wound healing process reveal possible causes for hypertrophic scars and keloids. This information might assist in the development of efficacious treatment for hypertrophic scar and keloid formation. SN - 1357-4310 UR - https://wwww.unboundmedicine.com/medline/citation/9494966/The_molecular_basis_of_keloid_and_hypertrophic_scar_formation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1357-4310(97)80541-2 DB - PRIME DP - Unbound Medicine ER -