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Potassium para-aminobenzoate for the treatment of Peyronie's disease: is it effective?
Tech Urol. 1997 Fall; 3(3):135-9.TU

Abstract

The medical treatment of Peyronie's disease remains controversial. Oral and injectable medications have been used with little documented disease specific effectiveness. Potassium para-aminobenzoate (POTABA) has long been suggested as a treatment for the plaque, curvature, and pain produced by chronic Peyronie's disease. We report a retrospective review of 32 patients treated for at least 3 months with 12 g of POTABA powder daily and followed for 8 to 24 months. Symptom resolution demonstrated improvement in penile discomfort in 8 of 18 patients, decreased plaque size in 18 of 32 patients, and improvement in penile angulation in 18 of 31 patients. Complete resolution of angulation was reported in 8 of 31 patients. While this review was retrospective and uncontrolled, it does suggest a place for POTABA in the treatment of Peyronie's disease. In order to confirm these findings and to control for the natural history of spontaneous resolution of Peyronie's disease symptomatology, a prospective, double-blind, multicenter, well-controlled study with objective criteria should be established.

Authors+Show Affiliations

Division of Urology, University of North Carolina, School of Medicine, Chapel Hill 27599-7235, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9422444

Citation

Carson, C C.. "Potassium Para-aminobenzoate for the Treatment of Peyronie's Disease: Is It Effective?" Techniques in Urology, vol. 3, no. 3, 1997, pp. 135-9.
Carson CC. Potassium para-aminobenzoate for the treatment of Peyronie's disease: is it effective? Tech Urol. 1997;3(3):135-9.
Carson, C. C. (1997). Potassium para-aminobenzoate for the treatment of Peyronie's disease: is it effective? Techniques in Urology, 3(3), 135-9.
Carson CC. Potassium Para-aminobenzoate for the Treatment of Peyronie's Disease: Is It Effective. Tech Urol. 1997;3(3):135-9. PubMed PMID: 9422444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potassium para-aminobenzoate for the treatment of Peyronie's disease: is it effective? A1 - Carson,C C, PY - 1998/1/9/pubmed PY - 1998/1/9/medline PY - 1998/1/9/entrez SP - 135 EP - 9 JF - Techniques in urology JO - Tech Urol VL - 3 IS - 3 N2 - The medical treatment of Peyronie's disease remains controversial. Oral and injectable medications have been used with little documented disease specific effectiveness. Potassium para-aminobenzoate (POTABA) has long been suggested as a treatment for the plaque, curvature, and pain produced by chronic Peyronie's disease. We report a retrospective review of 32 patients treated for at least 3 months with 12 g of POTABA powder daily and followed for 8 to 24 months. Symptom resolution demonstrated improvement in penile discomfort in 8 of 18 patients, decreased plaque size in 18 of 32 patients, and improvement in penile angulation in 18 of 31 patients. Complete resolution of angulation was reported in 8 of 31 patients. While this review was retrospective and uncontrolled, it does suggest a place for POTABA in the treatment of Peyronie's disease. In order to confirm these findings and to control for the natural history of spontaneous resolution of Peyronie's disease symptomatology, a prospective, double-blind, multicenter, well-controlled study with objective criteria should be established. SN - 1079-3259 UR - https://wwww.unboundmedicine.com/medline/citation/9422444/Potassium_para_aminobenzoate_for_the_treatment_of_Peyronie's_disease:_is_it_effective DB - PRIME DP - Unbound Medicine ER -