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Exercise-induced muscle damage: effect on circulating leukocyte and lymphocyte subsets.
Med Sci Sports Exerc. 1995 Mar; 27(3):363-70.MS

Abstract

The purpose of this study was to determine the effect of downhill and level running on circulating leukocyte and lymphocyte subsets and T lymphocyte activation. Using a random cross-over design, 10 runners completed two trials of 60 min of level running (0% grade; LR) and downhill running (-10% grade; DHR) at 70% of level VO2max. Blood samples were obtained preexercise and immediately postexercise (POST) and at 1.5, 12, 24, and 48 h of recovery. Creatine kinase activity peaked at 12 h of recovery from DHR and was not significantly altered following LR. The number of total T, CD16+, CD3+CD56+ cells were significantly higher POST DHR compared with LR. Leukocyte and neutrophil counts were significantly higher at 1.5 and 12 h of recovery from DHR compared with LR. The number of activated CD8+ cells (CD25+ CD8+) was significantly higher at 12 h of DHR compared to LR. Total T cells were significantly reduced at various time points during the 48 h of recovery from LR and DHR. In summary, DHR relative to LR resulted in a greater mobilization of lymphocytes (post), neutrophils (1.5-12 h of recovery) and activation of CD8+ cells at 12 h of recovery. In addition, reductions in circulating T lymphocyte subsets occurred following both conditions.

Authors+Show Affiliations

Department of Physical Education, Texas Christian University, Fort Worth 76129, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7752863

Citation

Pizza, F X., et al. "Exercise-induced Muscle Damage: Effect On Circulating Leukocyte and Lymphocyte Subsets." Medicine and Science in Sports and Exercise, vol. 27, no. 3, 1995, pp. 363-70.
Pizza FX, Mitchell JB, Davis BH, et al. Exercise-induced muscle damage: effect on circulating leukocyte and lymphocyte subsets. Med Sci Sports Exerc. 1995;27(3):363-70.
Pizza, F. X., Mitchell, J. B., Davis, B. H., Starling, R. D., Holtz, R. W., & Bigelow, N. (1995). Exercise-induced muscle damage: effect on circulating leukocyte and lymphocyte subsets. Medicine and Science in Sports and Exercise, 27(3), 363-70.
Pizza FX, et al. Exercise-induced Muscle Damage: Effect On Circulating Leukocyte and Lymphocyte Subsets. Med Sci Sports Exerc. 1995;27(3):363-70. PubMed PMID: 7752863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise-induced muscle damage: effect on circulating leukocyte and lymphocyte subsets. AU - Pizza,F X, AU - Mitchell,J B, AU - Davis,B H, AU - Starling,R D, AU - Holtz,R W, AU - Bigelow,N, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 363 EP - 70 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 27 IS - 3 N2 - The purpose of this study was to determine the effect of downhill and level running on circulating leukocyte and lymphocyte subsets and T lymphocyte activation. Using a random cross-over design, 10 runners completed two trials of 60 min of level running (0% grade; LR) and downhill running (-10% grade; DHR) at 70% of level VO2max. Blood samples were obtained preexercise and immediately postexercise (POST) and at 1.5, 12, 24, and 48 h of recovery. Creatine kinase activity peaked at 12 h of recovery from DHR and was not significantly altered following LR. The number of total T, CD16+, CD3+CD56+ cells were significantly higher POST DHR compared with LR. Leukocyte and neutrophil counts were significantly higher at 1.5 and 12 h of recovery from DHR compared with LR. The number of activated CD8+ cells (CD25+ CD8+) was significantly higher at 12 h of DHR compared to LR. Total T cells were significantly reduced at various time points during the 48 h of recovery from LR and DHR. In summary, DHR relative to LR resulted in a greater mobilization of lymphocytes (post), neutrophils (1.5-12 h of recovery) and activation of CD8+ cells at 12 h of recovery. In addition, reductions in circulating T lymphocyte subsets occurred following both conditions. SN - 0195-9131 UR - https://wwww.unboundmedicine.com/medline/citation/7752863/Exercise_induced_muscle_damage:_effect_on_circulating_leukocyte_and_lymphocyte_subsets_ L2 - https://Insights.ovid.com/pubmed?pmid=7752863 DB - PRIME DP - Unbound Medicine ER -