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Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function.
Acta Neurol Scand. 1988 Nov; 78(5):429-35.AN

Abstract

16 boys with Duchenne muscular dystrophy (DMD) were treated with sodium selenite and vitamin E for one year. One group of patients (10 boys) was examined using a battery of tests to assess muscular strength and function and cardiopulmonary function, and by CT scanning of 2 muscle groups over the 4 years prior to treatment. Six boys with DMD entered the study when the treatment was begun. Tests of muscular force and function, cardiopulmonary tests and CT-scanning were performed at the onset of treatment, and after 6 and 12 months. No beneficial effect on either muscular force or function was found during the treatment period. It is concluded that selenium and vitamin E in high doses do not improve muscle function in DMD.

Authors+Show Affiliations

Department of Neurophysiology, University Hospital, Linköping, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3218450

Citation

Bäckman, E, et al. "Selenium and Vitamin E Treatment of Duchenne Muscular Dystrophy: No Effect On Muscle Function." Acta Neurologica Scandinavica, vol. 78, no. 5, 1988, pp. 429-35.
Bäckman E, Nylander E, Johansson I, et al. Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function. Acta Neurol Scand. 1988;78(5):429-35.
Bäckman, E., Nylander, E., Johansson, I., Henriksson, K. G., & Tagesson, C. (1988). Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function. Acta Neurologica Scandinavica, 78(5), 429-35.
Bäckman E, et al. Selenium and Vitamin E Treatment of Duchenne Muscular Dystrophy: No Effect On Muscle Function. Acta Neurol Scand. 1988;78(5):429-35. PubMed PMID: 3218450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function. AU - Bäckman,E, AU - Nylander,E, AU - Johansson,I, AU - Henriksson,K G, AU - Tagesson,C, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 429 EP - 35 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 78 IS - 5 N2 - 16 boys with Duchenne muscular dystrophy (DMD) were treated with sodium selenite and vitamin E for one year. One group of patients (10 boys) was examined using a battery of tests to assess muscular strength and function and cardiopulmonary function, and by CT scanning of 2 muscle groups over the 4 years prior to treatment. Six boys with DMD entered the study when the treatment was begun. Tests of muscular force and function, cardiopulmonary tests and CT-scanning were performed at the onset of treatment, and after 6 and 12 months. No beneficial effect on either muscular force or function was found during the treatment period. It is concluded that selenium and vitamin E in high doses do not improve muscle function in DMD. SN - 0001-6314 UR - https://wwww.unboundmedicine.com/medline/citation/3218450/Selenium_and_vitamin_E_treatment_of_Duchenne_muscular_dystrophy:_no_effect_on_muscle_function_ DB - PRIME DP - Unbound Medicine ER -