Tags

Type your tag names separated by a space and hit enter

A Madras Motor Neuron Disease Patient With Cerebellar Atrophy: A New Clinical Feature.
Front Neurosci. 2018; 12:722.FN

Abstract

A 34-year-old Chinese Han female complaining of general muscle weakness and wasting for 9 years. She was admitted for aggravation of her symptoms caused by respiratory distress. She also suffered from bulbar palsy. She had no hearing loss, visual problems, or cerebellar signs. Her parents had a consanguineous marriage, though there was no family history of these symptoms. Pure tone audiometric findings demonstrated no definite abnormality. Electromyography demonstrated neurogenic damage. Brain magnetic resonance imaging revealed cerebellar atrophy, dominantly in anterior lobe. Gene sequencing of whole gene exomes was negative. She was finally diagnosed with Madras motor neuron disease (MMND), a rare subtype of motor neuron disease. No definite therapy was available for MMND, and she died of respiratory tract infection 1 year later. Previous studies have shown that cerebellar signs are positive in 17.2% patients of MMND, but no case with cerebellar atrophy has been reported before. Thus, here we describe cerebellar atrophy as a new clinical feature of MMND.

Authors+Show Affiliations

Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Neurology, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Otolaryngology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30349455

Citation

Long, Ling, et al. "A Madras Motor Neuron Disease Patient With Cerebellar Atrophy: a New Clinical Feature." Frontiers in Neuroscience, vol. 12, 2018, p. 722.
Long L, Cai X, Liu J, et al. A Madras Motor Neuron Disease Patient With Cerebellar Atrophy: A New Clinical Feature. Front Neurosci. 2018;12:722.
Long, L., Cai, X., Liu, J., Kang, Z., Li, J., Huang, Z., Guo, R., Zou, Y., & Lu, Z. (2018). A Madras Motor Neuron Disease Patient With Cerebellar Atrophy: A New Clinical Feature. Frontiers in Neuroscience, 12, 722. https://doi.org/10.3389/fnins.2018.00722
Long L, et al. A Madras Motor Neuron Disease Patient With Cerebellar Atrophy: a New Clinical Feature. Front Neurosci. 2018;12:722. PubMed PMID: 30349455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Madras Motor Neuron Disease Patient With Cerebellar Atrophy: A New Clinical Feature. AU - Long,Ling, AU - Cai,Xiaodong, AU - Liu,Jia, AU - Kang,Zhuang, AU - Li,Jing, AU - Huang,Zizhen, AU - Guo,Ruomi, AU - Zou,Yan, AU - Lu,Zhengqi, Y1 - 2018/10/08/ PY - 2018/07/04/received PY - 2018/09/20/accepted PY - 2018/10/24/entrez PY - 2018/10/24/pubmed PY - 2018/10/24/medline KW - MRI KW - atrophy KW - cerebellum KW - facial palsy KW - motor neuron disease SP - 722 EP - 722 JF - Frontiers in neuroscience JO - Front Neurosci VL - 12 N2 - A 34-year-old Chinese Han female complaining of general muscle weakness and wasting for 9 years. She was admitted for aggravation of her symptoms caused by respiratory distress. She also suffered from bulbar palsy. She had no hearing loss, visual problems, or cerebellar signs. Her parents had a consanguineous marriage, though there was no family history of these symptoms. Pure tone audiometric findings demonstrated no definite abnormality. Electromyography demonstrated neurogenic damage. Brain magnetic resonance imaging revealed cerebellar atrophy, dominantly in anterior lobe. Gene sequencing of whole gene exomes was negative. She was finally diagnosed with Madras motor neuron disease (MMND), a rare subtype of motor neuron disease. No definite therapy was available for MMND, and she died of respiratory tract infection 1 year later. Previous studies have shown that cerebellar signs are positive in 17.2% patients of MMND, but no case with cerebellar atrophy has been reported before. Thus, here we describe cerebellar atrophy as a new clinical feature of MMND. SN - 1662-4548 UR - https://wwww.unboundmedicine.com/medline/citation/30349455/A_Madras_Motor_Neuron_Disease_Patient_With_Cerebellar_Atrophy:_A_New_Clinical_Feature_ L2 - https://doi.org/10.3389/fnins.2018.00722 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.