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Gallstones were associated with the gastrointestinal adverse events of cinacalcet in hemodialysis patients with secondary hyperparathyroidism.
Ren Fail. 2018 Nov; 40(1):38-42.RF

Abstract

This study aimed to investigate the association of gastrointestinal (GI) adverse events of cinacalcet with gallstones in the hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT). A total of 23 HD patients under the treatment with cinacalcet and 101 control patients were enrolled in this cross-sectional study. We investigated the prevalence of gallstones and the association of GI adverse events of cinacalcet with gallstones. The prevalence of gallstones was significantly higher in the HD patients with cinacalcet compared with the controls (47.8% vs. 15.8%). The longer time on HD, hypercalcemia, hyperphosphatemia and elevated parathyroid hormone level were observed in the HD patients with cinacalcet. Besides, GI adverse events of cinacalcet were observed more frequently in the HD patients with gallstones compared with those without gallstones (odds ratio 13.5, 95% CI: 1.80-101). Therefore, screening for gallstones before dosing cinacalcet may reduce the risk of GI adverse events in SHPT patients.

Authors+Show Affiliations

a Department of Internal Medicine, Oshima Clinic , Saitama , Japan.b Department of Nephrology , Saitama Medical School , Saitama , Japan.a Department of Internal Medicine, Oshima Clinic , Saitama , Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29301445

Citation

Otsuka, Keiichi, et al. "Gallstones Were Associated With the Gastrointestinal Adverse Events of Cinacalcet in Hemodialysis Patients With Secondary Hyperparathyroidism." Renal Failure, vol. 40, no. 1, 2018, pp. 38-42.
Otsuka K, Ohno Y, Oshima J. Gallstones were associated with the gastrointestinal adverse events of cinacalcet in hemodialysis patients with secondary hyperparathyroidism. Ren Fail. 2018;40(1):38-42.
Otsuka, K., Ohno, Y., & Oshima, J. (2018). Gallstones were associated with the gastrointestinal adverse events of cinacalcet in hemodialysis patients with secondary hyperparathyroidism. Renal Failure, 40(1), 38-42. https://doi.org/10.1080/0886022X.2017.1419971
Otsuka K, Ohno Y, Oshima J. Gallstones Were Associated With the Gastrointestinal Adverse Events of Cinacalcet in Hemodialysis Patients With Secondary Hyperparathyroidism. Ren Fail. 2018;40(1):38-42. PubMed PMID: 29301445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gallstones were associated with the gastrointestinal adverse events of cinacalcet in hemodialysis patients with secondary hyperparathyroidism. AU - Otsuka,Keiichi, AU - Ohno,Yoichi, AU - Oshima,Joji, PY - 2018/1/6/entrez PY - 2018/1/6/pubmed PY - 2018/9/11/medline KW - Cinacalcet hydrochloride KW - gallstones KW - gastrointestinal adverse events KW - hemodialysis KW - secondary hyperparathyroidism SP - 38 EP - 42 JF - Renal failure JO - Ren Fail VL - 40 IS - 1 N2 - This study aimed to investigate the association of gastrointestinal (GI) adverse events of cinacalcet with gallstones in the hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT). A total of 23 HD patients under the treatment with cinacalcet and 101 control patients were enrolled in this cross-sectional study. We investigated the prevalence of gallstones and the association of GI adverse events of cinacalcet with gallstones. The prevalence of gallstones was significantly higher in the HD patients with cinacalcet compared with the controls (47.8% vs. 15.8%). The longer time on HD, hypercalcemia, hyperphosphatemia and elevated parathyroid hormone level were observed in the HD patients with cinacalcet. Besides, GI adverse events of cinacalcet were observed more frequently in the HD patients with gallstones compared with those without gallstones (odds ratio 13.5, 95% CI: 1.80-101). Therefore, screening for gallstones before dosing cinacalcet may reduce the risk of GI adverse events in SHPT patients. SN - 1525-6049 UR - https://wwww.unboundmedicine.com/medline/citation/29301445/Gallstones_were_associated_with_the_gastrointestinal_adverse_events_of_cinacalcet_in_hemodialysis_patients_with_secondary_hyperparathyroidism_ L2 - https://www.tandfonline.com/doi/full/10.1080/0886022X.2017.1419971 DB - PRIME DP - Unbound Medicine ER -