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The effects of a multi-ingredient supplement on markers of muscle damage and inflammation following downhill running in females.
J Int Soc Sports Nutr. 2016; 13:44.JI

Abstract

BACKGROUND

The effects of a multi-ingredient performance supplement (MIPS) on markers of inflammation and muscle damage, perceived soreness and lower limb performance are unknown in endurance-trained female athletes. The purpose of this study was to determine the impact of MIPS (NO-Shotgun®) pre-loaded 4 weeks prior to a single-bout of downhill running (DHR) on hsC-Reactive Protein (hsCRP), interleukin (IL)-6, creatine kinase (CK), muscle soreness, lower limb circumferences and performance.

METHOD

Trained female runners (n = 8; 29 ± 5.9 years) (VO2max: ≥ 50 ml-1.kg-1.min-1, midfollicular phase (7-11 days post-menses) were randomly assigned in a double-blind manner into two groups: MIPS (n = 4) ingested one serving of NO Shotgun daily for 28 days prior to DHR and 30 min prior to all post-testing visits; Control (CON) (n = 4) consumed an isocaloric maltodextrin placebo in an identical manner to MIPS. hsCRP, IL-6, CK, perceived soreness, limb circumferences, and performance measures (flexibility, squat jump peak power) were tested on 5 occasions; immediately before (PRE), immediately post-DHR, 24, 48 and 72 h post-DHR.

RESULTS

There were main effects of time for CK (p = 0.05), pain pressure threshold (right tibialis anterior (p = 0.010), right biceps femoris (p = 0.01), and left iliotibial band (ITB) (p = 0.05) across all time points), and maximum squat jump power (p = 0.04). Compared with 24 h post-DHR, maximum squat jump power was significantly lower at 48 h post-DHR (p = 0.05). Lower body perceived soreness was significantly increased at 24 h (p = 0.02) and baseline to 48 h (p = 0.02) post DHR. IL-6 peaked immediately post-DHR (p = 0.03) and hsCRP peaked at 24 h post-DHR (p = 0.06). Calculation of effect sizes indicated a moderate attenuation of hsCRP in MIPS at 72 h post-DHR.

CONCLUSIONS

Consumption of MIPS for 4 weeks prior to a single bout of DHR attenuated inflammation three days post, but did not affect perceived soreness and muscle damage markers in endurance trained female runners following a single bout of DHR.

Authors+Show Affiliations

Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa ; Department of Nutrition, Food and Exercise Sciences, Institute of Sport Sciences and Medicine, Florida State University, Tallahassee, USA.Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa ; Department of Nutrition, Food and Exercise Sciences, Institute of Sport Sciences and Medicine, Florida State University, Tallahassee, USA ; Discipline of Sport and Exercise Science, University of Canberra Research Institute for Sport and Exercise, Faculty of Health, University of Canberra, Canberra, Australia.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27924138

Citation

Köhne, Jessica L., et al. "The Effects of a Multi-ingredient Supplement On Markers of Muscle Damage and Inflammation Following Downhill Running in Females." Journal of the International Society of Sports Nutrition, vol. 13, 2016, p. 44.
Köhne JL, Ormsbee MJ, McKune AJ. The effects of a multi-ingredient supplement on markers of muscle damage and inflammation following downhill running in females. J Int Soc Sports Nutr. 2016;13:44.
Köhne, J. L., Ormsbee, M. J., & McKune, A. J. (2016). The effects of a multi-ingredient supplement on markers of muscle damage and inflammation following downhill running in females. Journal of the International Society of Sports Nutrition, 13, 44.
Köhne JL, Ormsbee MJ, McKune AJ. The Effects of a Multi-ingredient Supplement On Markers of Muscle Damage and Inflammation Following Downhill Running in Females. J Int Soc Sports Nutr. 2016;13:44. PubMed PMID: 27924138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of a multi-ingredient supplement on markers of muscle damage and inflammation following downhill running in females. AU - Köhne,Jessica L, AU - Ormsbee,Michael J, AU - McKune,Andrew J, Y1 - 2016/11/25/ PY - 2016/05/24/received PY - 2016/11/19/accepted PY - 2016/12/8/entrez PY - 2016/12/8/pubmed PY - 2017/6/29/medline KW - Eccentric exercise KW - Muscle soreness KW - Recovery SP - 44 EP - 44 JF - Journal of the International Society of Sports Nutrition JO - J Int Soc Sports Nutr VL - 13 N2 - BACKGROUND: The effects of a multi-ingredient performance supplement (MIPS) on markers of inflammation and muscle damage, perceived soreness and lower limb performance are unknown in endurance-trained female athletes. The purpose of this study was to determine the impact of MIPS (NO-Shotgun®) pre-loaded 4 weeks prior to a single-bout of downhill running (DHR) on hsC-Reactive Protein (hsCRP), interleukin (IL)-6, creatine kinase (CK), muscle soreness, lower limb circumferences and performance. METHOD: Trained female runners (n = 8; 29 ± 5.9 years) (VO2max: ≥ 50 ml-1.kg-1.min-1, midfollicular phase (7-11 days post-menses) were randomly assigned in a double-blind manner into two groups: MIPS (n = 4) ingested one serving of NO Shotgun daily for 28 days prior to DHR and 30 min prior to all post-testing visits; Control (CON) (n = 4) consumed an isocaloric maltodextrin placebo in an identical manner to MIPS. hsCRP, IL-6, CK, perceived soreness, limb circumferences, and performance measures (flexibility, squat jump peak power) were tested on 5 occasions; immediately before (PRE), immediately post-DHR, 24, 48 and 72 h post-DHR. RESULTS: There were main effects of time for CK (p = 0.05), pain pressure threshold (right tibialis anterior (p = 0.010), right biceps femoris (p = 0.01), and left iliotibial band (ITB) (p = 0.05) across all time points), and maximum squat jump power (p = 0.04). Compared with 24 h post-DHR, maximum squat jump power was significantly lower at 48 h post-DHR (p = 0.05). Lower body perceived soreness was significantly increased at 24 h (p = 0.02) and baseline to 48 h (p = 0.02) post DHR. IL-6 peaked immediately post-DHR (p = 0.03) and hsCRP peaked at 24 h post-DHR (p = 0.06). Calculation of effect sizes indicated a moderate attenuation of hsCRP in MIPS at 72 h post-DHR. CONCLUSIONS: Consumption of MIPS for 4 weeks prior to a single bout of DHR attenuated inflammation three days post, but did not affect perceived soreness and muscle damage markers in endurance trained female runners following a single bout of DHR. SN - 1550-2783 UR - https://wwww.unboundmedicine.com/medline/citation/27924138/The_effects_of_a_multi_ingredient_supplement_on_markers_of_muscle_damage_and_inflammation_following_downhill_running_in_females_ DB - PRIME DP - Unbound Medicine ER -