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Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial.

Abstract

This triple-blind trial examined the effects of Calendula officinalis vaginal cream on the treatment of vaginal Candidiasis (primary outcome) and sexual function (secondary outcome). Married women aged 18-45 years with vaginal Candidiasis (n = 150) were recruited from April to October 2014 and randomized into Calendula and clotrimazole groups, using 5-g vaginal cream every night for seven nights. Clinical and laboratory assessments were conducted at 10-15 and 30-35 days after intervention and the female sexual function index was assessed at 30-35 days. Six women were lost to follow-up. The frequency of testing negative for Candidiasis in the Calendula group was significantly lower at the first (49% vs. 74%; odds ratio (OR) 0.32; 95% confidence interval (CI) 0.16-0.67) but higher at the second (77% vs. 34%; OR 3.1; 95% CI 1.5-6.2) follow-up compared to the clotrimazole group. The frequency of most signs and symptoms were almost equal in the two groups at the first follow-up, but were significantly lower in the Calendula group at the second follow-up. Sexual function had almost equal significant improvement in both groups. Calendula vaginal cream appears to have been effective in the treatment of vaginal Candidiasis and to have a delayed but greater long-term effect compared to clotrimazole.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    a Students' Research Committee, Department of Midwifery , Tabriz University of Medical Sciences , Tabriz , Iran.

    ,

    b Social Determinants of Health Research Centre, Department of Midwifery , Tabriz University of Medical Sciences , Tabriz , Iran.

    ,

    c Department of Parasitology , Tabriz University of Medical Sciences , Tabriz , Iran.

    ,

    d Department of Midwifery , Tabriz University of Medical Sciences , Tabriz , Iran.

    e Department of Pharmaceutics , Tabriz University of Medical Sciences , Tabriz , Iran.

    Source

    Women & health 57:10 pg 1145-1160

    MeSH

    Administration, Intravaginal
    Adolescent
    Adult
    Calendula
    Candidiasis, Vulvovaginal
    Clotrimazole
    Female
    Humans
    Middle Aged
    Plant Extracts
    Treatment Outcome
    Vaginal Creams, Foams, and Jellies
    Young Adult

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    27880086