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Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children.
Ophthalmic Physiol Opt. 2016 07; 36(4):388-94.OP

Abstract

PURPOSE

To investigate the effect of age of myopia onset on the severity of myopia later in life among myopic children.

METHODS

In this prospective study, school children aged 7-9 years from the Singapore Cohort Of the Risk factors for Myopia (SCORM) were followed up till 11 years (n = 928). Age of myopia onset was defined either through questionnaire at baseline (age 7-9 years) or subsequent annual follow-up visits. Age of onset of myopia was a surrogate indicator of duration of myopia progression till age 11 years. Cycloplegic refraction and axial length were measured at every annual eye examination. High myopia was defined as spherical equivalent of ≤-5.0 D. A questionnaire determined the other risk factors.

RESULTS

In multivariable regression models, younger age of myopia onset (per year decrease) or longer duration of myopia progression was associated with high myopia (odds ratio (OR) = 2.86; 95% CI: 2.39 to 3.43), more myopic spherical equivalent (regression coefficient (β) = -0.86 D; 95% CI: -0.93 to -0.80) and longer axial length (β = 0.28 mm; 95% CI: 0.24 to 0.32) at aged 11 years, after adjusting for gender, race, school, books per week and parental myopia. In Receiver Operating Curve (ROC) analyses, age of myopia onset alone predicted high myopia by 85% (area under the curve = 0.85), while the addition of other factors including gender, race, school, books per week and parental myopia only marginally improved this prediction (area under the curve = 0.87).

CONCLUSIONS

Age of myopia onset or duration of myopia progression was the most important predictor of high myopia in later childhood in myopic children. Future trials to retard the progression of myopia to high myopia could focus on children with younger age of myopia onset or with longer duration of myopia progression.

Authors+Show Affiliations

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.Genome Institute of Singapore, A*STAR, Singapore, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27350183

Citation

Chua, Sharon Y L., et al. "Age of Onset of Myopia Predicts Risk of High Myopia in Later Childhood in Myopic Singapore Children." Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists), vol. 36, no. 4, 2016, pp. 388-94.
Chua SY, Sabanayagam C, Cheung YB, et al. Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children. Ophthalmic Physiol Opt. 2016;36(4):388-94.
Chua, S. Y., Sabanayagam, C., Cheung, Y. B., Chia, A., Valenzuela, R. K., Tan, D., Wong, T. Y., Cheng, C. Y., & Saw, S. M. (2016). Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children. Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists), 36(4), 388-94. https://doi.org/10.1111/opo.12305
Chua SY, et al. Age of Onset of Myopia Predicts Risk of High Myopia in Later Childhood in Myopic Singapore Children. Ophthalmic Physiol Opt. 2016;36(4):388-94. PubMed PMID: 27350183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children. AU - Chua,Sharon Y L, AU - Sabanayagam,Charumathi, AU - Cheung,Yin-Bun, AU - Chia,Audrey, AU - Valenzuela,Robert K, AU - Tan,Donald, AU - Wong,Tien-Yin, AU - Cheng,Ching-Yu, AU - Saw,Seang-Mei, PY - 2016/04/04/received PY - 2016/05/11/accepted PY - 2016/6/29/entrez PY - 2016/6/29/pubmed PY - 2017/7/6/medline KW - age of myopia onset KW - axial length KW - children KW - high myopia KW - myopia KW - spherical equivalent SP - 388 EP - 94 JF - Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) JO - Ophthalmic Physiol Opt VL - 36 IS - 4 N2 - PURPOSE: To investigate the effect of age of myopia onset on the severity of myopia later in life among myopic children. METHODS: In this prospective study, school children aged 7-9 years from the Singapore Cohort Of the Risk factors for Myopia (SCORM) were followed up till 11 years (n = 928). Age of myopia onset was defined either through questionnaire at baseline (age 7-9 years) or subsequent annual follow-up visits. Age of onset of myopia was a surrogate indicator of duration of myopia progression till age 11 years. Cycloplegic refraction and axial length were measured at every annual eye examination. High myopia was defined as spherical equivalent of ≤-5.0 D. A questionnaire determined the other risk factors. RESULTS: In multivariable regression models, younger age of myopia onset (per year decrease) or longer duration of myopia progression was associated with high myopia (odds ratio (OR) = 2.86; 95% CI: 2.39 to 3.43), more myopic spherical equivalent (regression coefficient (β) = -0.86 D; 95% CI: -0.93 to -0.80) and longer axial length (β = 0.28 mm; 95% CI: 0.24 to 0.32) at aged 11 years, after adjusting for gender, race, school, books per week and parental myopia. In Receiver Operating Curve (ROC) analyses, age of myopia onset alone predicted high myopia by 85% (area under the curve = 0.85), while the addition of other factors including gender, race, school, books per week and parental myopia only marginally improved this prediction (area under the curve = 0.87). CONCLUSIONS: Age of myopia onset or duration of myopia progression was the most important predictor of high myopia in later childhood in myopic children. Future trials to retard the progression of myopia to high myopia could focus on children with younger age of myopia onset or with longer duration of myopia progression. SN - 1475-1313 UR - https://wwww.unboundmedicine.com/medline/citation/27350183/Age_of_onset_of_myopia_predicts_risk_of_high_myopia_in_later_childhood_in_myopic_Singapore_children_ DB - PRIME DP - Unbound Medicine ER -