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The Preterm Infant: A High-Risk Situation for Neonatal Hyperbilirubinemia Due to Glucose-6-Phosphate Dehydrogenase Deficiency.
Clin Perinatol. 2016 Jun; 43(2):325-40.CP

Abstract

Prematurity and glucose-6-phosphate dehydrogenase (G6PD) deficiency are risk factors for neonatal hyperbilirubinemia. The 2 conditions may interact additively or synergistically, contributing to extreme hyperbilirubinemia, with the potential for bilirubin neurotoxicity. This hyperbilirubinemia is the result of sudden, unpredictable, and acute episodes of hemolysis in combination with immaturity of bilirubin elimination, primarily of conjugation. Avoidance of contact with known triggers of hemolysis in G6PD-deficient individuals will prevent some, but not all, episodes of hemolysis. All preterm infants with G6PD deficiency should be vigilantly observed for the development of jaundice both in hospital and after discharge home.

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Authors+Show Affiliations

Kaplan M
Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, P.O. Box 12271, Jerusalem, 9112102 Israel; Department of Neonatology, Shaare Zedek Medical Center, PO Box 3235, Jerusalem 91031, Israel. Electronic address: mkaplan@mail.huji.ac.il.
Hammerman C
Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, P.O. Box 12271, Jerusalem, 9112102 Israel; Department of Neonatology, Shaare Zedek Medical Center, PO Box 3235, Jerusalem 91031, Israel.
Bhutani VK
Department of Pediatrics, Stanford University School of Medicine, 750 Welch Road, Suite 315, Palo Alto, CA 94305, USA.

MeSH

Glucosephosphate Dehydrogenase DeficiencyHemolysisHumansHyperbilirubinemia, NeonatalInfant, NewbornInfant, PrematureKernicterusMass ScreeningRisk Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27235211

Citation

Kaplan, Michael, et al. "The Preterm Infant: a High-Risk Situation for Neonatal Hyperbilirubinemia Due to Glucose-6-Phosphate Dehydrogenase Deficiency." Clinics in Perinatology, vol. 43, no. 2, 2016, pp. 325-40.
Kaplan M, Hammerman C, Bhutani VK. The Preterm Infant: A High-Risk Situation for Neonatal Hyperbilirubinemia Due to Glucose-6-Phosphate Dehydrogenase Deficiency. Clin Perinatol. 2016;43(2):325-40.
Kaplan, M., Hammerman, C., & Bhutani, V. K. (2016). The Preterm Infant: A High-Risk Situation for Neonatal Hyperbilirubinemia Due to Glucose-6-Phosphate Dehydrogenase Deficiency. Clinics in Perinatology, 43(2), 325-40. https://doi.org/10.1016/j.clp.2016.01.008
Kaplan M, Hammerman C, Bhutani VK. The Preterm Infant: a High-Risk Situation for Neonatal Hyperbilirubinemia Due to Glucose-6-Phosphate Dehydrogenase Deficiency. Clin Perinatol. 2016;43(2):325-40. PubMed PMID: 27235211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Preterm Infant: A High-Risk Situation for Neonatal Hyperbilirubinemia Due to Glucose-6-Phosphate Dehydrogenase Deficiency. AU - Kaplan,Michael, AU - Hammerman,Cathy, AU - Bhutani,Vinod K, Y1 - 2016/02/28/ PY - 2016/5/29/entrez PY - 2016/5/29/pubmed PY - 2017/10/19/medline KW - Bilirubin conjugation KW - Bilirubin encephalopathy KW - Glucose-6-phosphate dehydrogenase deficiency KW - Hemolysis KW - Hyperbilirubinemia KW - Kernicterus KW - Prematurity SP - 325 EP - 40 JF - Clinics in perinatology JO - Clin Perinatol VL - 43 IS - 2 N2 - Prematurity and glucose-6-phosphate dehydrogenase (G6PD) deficiency are risk factors for neonatal hyperbilirubinemia. The 2 conditions may interact additively or synergistically, contributing to extreme hyperbilirubinemia, with the potential for bilirubin neurotoxicity. This hyperbilirubinemia is the result of sudden, unpredictable, and acute episodes of hemolysis in combination with immaturity of bilirubin elimination, primarily of conjugation. Avoidance of contact with known triggers of hemolysis in G6PD-deficient individuals will prevent some, but not all, episodes of hemolysis. All preterm infants with G6PD deficiency should be vigilantly observed for the development of jaundice both in hospital and after discharge home. SN - 1557-9840 UR - https://wwww.unboundmedicine.com/medline/citation/27235211/The_Preterm_Infant:_A_High_Risk_Situation_for_Neonatal_Hyperbilirubinemia_Due_to_Glucose_6_Phosphate_Dehydrogenase_Deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0095-5108(16)00009-9 DB - PRIME DP - Unbound Medicine ER -