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Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature.
Int J Surg Pathol. 2015 Aug; 23(5):393-8.IJ

Abstract

Gynandroblastoma is an extremely rare primary tumor of the ovary showing morphological evidence of both female (granulosa cell tumor) and male (Sertoli or Sertoli-Leydig tumor) differentiation. We report an unusual case of a 32-year-old female who presented with hyperandrogenism and was found on imaging to have concurrent ovarian and renal masses. Following surgical excision, the ovarian mass was diagnosed as gynandroblastoma, which consisted of 45% juvenile granulosa cell tumor and 55% intermediately differentiated Sertoli-Leydig tumor. The renal mass was diagnosed as a conventional renal clear cell carcinoma. Gynandroblastoma, especially with juvenile granulosa cell tumor, is an extremely rare ovarian tumor. Concurrent gynandroblastoma with another malignant neoplasm has not been reported in the literature.

Authors+Show Affiliations

Cleveland Clinic, Cleveland, OH, USA.Cleveland Clinic, Cleveland, OH, USA yangb@ccf.org.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

26169919

Citation

Wilberger, Adam, and Bin Yang. "Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: a Case Report and Review of Literature." International Journal of Surgical Pathology, vol. 23, no. 5, 2015, pp. 393-8.
Wilberger A, Yang B. Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. Int J Surg Pathol. 2015;23(5):393-8.
Wilberger, A., & Yang, B. (2015). Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. International Journal of Surgical Pathology, 23(5), 393-8. https://doi.org/10.1177/1066896915573569
Wilberger A, Yang B. Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: a Case Report and Review of Literature. Int J Surg Pathol. 2015;23(5):393-8. PubMed PMID: 26169919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. AU - Wilberger,Adam, AU - Yang,Bin, PY - 2015/7/15/entrez PY - 2015/7/15/pubmed PY - 2016/4/6/medline KW - Sertoli–Leydig cell tumor KW - gynandroblastoma KW - juvenile granulosa cell tumor KW - ovary KW - renal cell carcinoma SP - 393 EP - 8 JF - International journal of surgical pathology JO - Int. J. Surg. Pathol. VL - 23 IS - 5 N2 - Gynandroblastoma is an extremely rare primary tumor of the ovary showing morphological evidence of both female (granulosa cell tumor) and male (Sertoli or Sertoli-Leydig tumor) differentiation. We report an unusual case of a 32-year-old female who presented with hyperandrogenism and was found on imaging to have concurrent ovarian and renal masses. Following surgical excision, the ovarian mass was diagnosed as gynandroblastoma, which consisted of 45% juvenile granulosa cell tumor and 55% intermediately differentiated Sertoli-Leydig tumor. The renal mass was diagnosed as a conventional renal clear cell carcinoma. Gynandroblastoma, especially with juvenile granulosa cell tumor, is an extremely rare ovarian tumor. Concurrent gynandroblastoma with another malignant neoplasm has not been reported in the literature. SN - 1940-2465 UR - https://wwww.unboundmedicine.com/medline/citation/26169919/Gynandroblastoma_With_Juvenile_Granulosa_Cell_Tumor_and_Concurrent_Renal_Cell_Carcinoma:_A_Case_Report_and_Review_of_Literature_ L2 - http://journals.sagepub.com/doi/full/10.1177/1066896915573569?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -