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Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men with Peyronie's Disease Independent of Plaque Location.
J Urol. 2015 Dec; 194(6):1704-7.JU

Abstract

PURPOSE

Collagenase clostridium histolyticum is the only FDA (Food and Drug Administration) approved treatment for Peyronie's disease. However, to our knowledge collagenase clostridium histolyticum has not been studied in men with ventral plaques. Given this limitation and the paucity of literature on ventral plaque outcomes, we compared the results of Peyronie's disease treatment in men with different plaque locations treated with intralesional interferon-α2b.

MATERIALS AND METHODS

We retrospectively analyzed the records of men treated with intralesional interferon-α2b for Peyronie's disease at 1 institution from 2001 to 2014. The men received 2 million U interferon-α2b injected every 2 weeks for 6 to 24 treatments. All men underwent penile duplex Doppler ultrasound before and after interferon-α2b treatment. Patient characteristics, penile duplex Doppler ultrasound and objective measurements were reviewed. Patients were stratified into ventral and dorsal/lateral plaque cohorts with a positive response defined as a 20% or greater reduction in curvature.

RESULTS

A total of 131 patients with a mean±SD age of 53.8±9.5 years underwent a median of 12 intralesional interferon-α2b injections (range 6 to 24). Mean pretreatment dorsal curvature was 42.5±18.6 degrees in group 1 of 111 men and mean ventral curvature was 44.5±21.5 degrees in group 2 of 21 men (p=0.66). Overall 91% of patients responded to therapy. No significant difference was noted between the 2 groups in response rate (54% vs 52%, p=0.92) or absolute change in curvature (mean 8.7±12.6 vs 9.3±17.7 degrees, p=0.84).

CONCLUSIONS

Treatment with intralesional interferon-α2b provided a greater than 20% reduction in curvature in the majority of men with Peyronie's disease. This improvement was independent of plaque location.

Authors+Show Affiliations

Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota.Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana; Department of Urology, Mayo Clinic (LT), Rochester, Minnesota. Electronic address: whellst@tulane.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26144333

Citation

Stewart, Carrie A., et al. "Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men With Peyronie's Disease Independent of Plaque Location." The Journal of Urology, vol. 194, no. 6, 2015, pp. 1704-7.
Stewart CA, Yafi FA, Knoedler M, et al. Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men with Peyronie's Disease Independent of Plaque Location. J Urol. 2015;194(6):1704-7.
Stewart, C. A., Yafi, F. A., Knoedler, M., Mandava, S. H., McCaslin, I. R., Sangkum, P., Sikka, S., Trost, L., & Hellstrom, W. J. (2015). Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men with Peyronie's Disease Independent of Plaque Location. The Journal of Urology, 194(6), 1704-7. https://doi.org/10.1016/j.juro.2015.06.096
Stewart CA, et al. Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men With Peyronie's Disease Independent of Plaque Location. J Urol. 2015;194(6):1704-7. PubMed PMID: 26144333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men with Peyronie's Disease Independent of Plaque Location. AU - Stewart,Carrie A, AU - Yafi,Faysal A, AU - Knoedler,Margaret, AU - Mandava,Sree H, AU - McCaslin,Ian R, AU - Sangkum,Premsant, AU - Sikka,Suresh, AU - Trost,Landon, AU - Hellstrom,Wayne J G, Y1 - 2015/07/03/ PY - 2015/06/17/accepted PY - 2015/7/7/entrez PY - 2015/7/7/pubmed PY - 2016/3/2/medline KW - erectile dysfunction KW - injections KW - interferons KW - intralesional KW - penile induration KW - penis SP - 1704 EP - 7 JF - The Journal of urology JO - J Urol VL - 194 IS - 6 N2 - PURPOSE: Collagenase clostridium histolyticum is the only FDA (Food and Drug Administration) approved treatment for Peyronie's disease. However, to our knowledge collagenase clostridium histolyticum has not been studied in men with ventral plaques. Given this limitation and the paucity of literature on ventral plaque outcomes, we compared the results of Peyronie's disease treatment in men with different plaque locations treated with intralesional interferon-α2b. MATERIALS AND METHODS: We retrospectively analyzed the records of men treated with intralesional interferon-α2b for Peyronie's disease at 1 institution from 2001 to 2014. The men received 2 million U interferon-α2b injected every 2 weeks for 6 to 24 treatments. All men underwent penile duplex Doppler ultrasound before and after interferon-α2b treatment. Patient characteristics, penile duplex Doppler ultrasound and objective measurements were reviewed. Patients were stratified into ventral and dorsal/lateral plaque cohorts with a positive response defined as a 20% or greater reduction in curvature. RESULTS: A total of 131 patients with a mean±SD age of 53.8±9.5 years underwent a median of 12 intralesional interferon-α2b injections (range 6 to 24). Mean pretreatment dorsal curvature was 42.5±18.6 degrees in group 1 of 111 men and mean ventral curvature was 44.5±21.5 degrees in group 2 of 21 men (p=0.66). Overall 91% of patients responded to therapy. No significant difference was noted between the 2 groups in response rate (54% vs 52%, p=0.92) or absolute change in curvature (mean 8.7±12.6 vs 9.3±17.7 degrees, p=0.84). CONCLUSIONS: Treatment with intralesional interferon-α2b provided a greater than 20% reduction in curvature in the majority of men with Peyronie's disease. This improvement was independent of plaque location. SN - 1527-3792 UR - https://wwww.unboundmedicine.com/medline/citation/26144333/Intralesional_Injection_of_Interferon_α2b_Improves_Penile_Curvature_in_Men_with_Peyronie's_Disease_Independent_of_Plaque_Location_ L2 - https://www.jurology.com/doi/10.1016/j.juro.2015.06.096?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -