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Use of a decision aid including information on overdetection to support informed choice about breast cancer screening: a randomised controlled trial.
Lancet 2015; 385(9978):1642-52Lct

Abstract

BACKGROUND

Mammography screening can reduce breast cancer mortality. However, most women are unaware that inconsequential disease can also be detected by screening, leading to overdiagnosis and overtreatment. We aimed to investigate whether including information about overdetection of breast cancer in a decision aid would help women aged around 50 years to make an informed choice about breast screening.

METHODS

We did a community-based, parallel-group, randomised controlled trial in New South Wales, Australia, using a random cohort of women aged 48-50 years. Recruitment to the study was done by telephone; women were eligible if they had not had mammography in the past 2 years and did not have a personal or strong family history of breast cancer. With a computer program, we randomly assigned 879 participants to either the intervention decision aid (comprising evidence-based explanatory and quantitative information on overdetection, breast cancer mortality reduction, and false positives) or a control decision aid (including information on breast cancer mortality reduction and false positives). Participants and interviewers were masked to group assignment. The primary outcome was informed choice (defined as adequate knowledge and consistency between attitudes and screening intentions), which we assessed by telephone interview about 3 weeks after random allocation. The primary outcome was analysed in all women who completed the relevant follow-up interview questions fully. This trial is registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12613001035718.

FINDINGS

Between January, 2014, and July, 2014, 440 women were allocated to the intervention group and 439 were assigned to the control group. 21 women in the intervention group and 20 controls were lost to follow-up; a further ten women assigned to the intervention and 11 controls did not answer all questions on attitudes. Therefore, 409 women in the intervention group and 408 controls were analysed for the primary outcome. 99 (24%) of 409 women in the intervention group made an informed choice compared with 63 (15%) of 408 in the control group (difference 9%, 95% CI 3-14; p=0·0017). Compared with controls, more women in the intervention group met the threshold for adequate overall knowledge (122/419 [29%] vs 71/419 [17%]; difference 12%, 95% CI 6-18; p<0·0001), fewer women expressed positive attitudes towards screening (282/409 [69%] vs 340/408 [83%]; 14%, 9-20; p<0·0001), and fewer women intended to be screened (308/419 [74%] vs 363/419 [87%]; 13%, 8-19; p<0·0001). When conceptual knowledge alone was considered, 203 (50%) of 409 women in the intervention group made an informed choice compared with 79 (19%) of 408 in the control group (p<0·0001).

INTERPRETATION

Information on overdetection of breast cancer provided within a decision aid increased the number of women making an informed choice about breast screening. Becoming better informed might mean women are less likely to choose screening.

FUNDING

Australian National Health and Medical Research Council.

Authors+Show Affiliations

Screening & Test Evaluation Program (STEP), The University of Sydney, Sydney, NSW 2006, Australia; Centre for Medical Psychology & Evidence-based Decision-making (CeMPED), The University of Sydney, Sydney, NSW 2006, Australia.Centre for Medical Psychology & Evidence-based Decision-making (CeMPED), The University of Sydney, Sydney, NSW 2006, Australia.Screening & Test Evaluation Program (STEP), The University of Sydney, Sydney, NSW 2006, Australia; Centre for Medical Psychology & Evidence-based Decision-making (CeMPED), The University of Sydney, Sydney, NSW 2006, Australia.Screening & Test Evaluation Program (STEP), The University of Sydney, Sydney, NSW 2006, Australia.Centre for Medical Psychology & Evidence-based Decision-making (CeMPED), The University of Sydney, Sydney, NSW 2006, Australia.School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia.Department of Health Sciences, University of Leicester; Leicester, UK.Centre for Medical Psychology & Evidence-based Decision-making (CeMPED), The University of Sydney, Sydney, NSW 2006, Australia; Central Clinical School, The University of Sydney, Sydney, NSW 2006, Australia.Screening & Test Evaluation Program (STEP), The University of Sydney, Sydney, NSW 2006, Australia.Screening & Test Evaluation Program (STEP), The University of Sydney, Sydney, NSW 2006, Australia; Centre for Medical Psychology & Evidence-based Decision-making (CeMPED), The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: kirsten.mccaffery@sydney.edu.au.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25701273

Citation

Hersch, Jolyn, et al. "Use of a Decision Aid Including Information On Overdetection to Support Informed Choice About Breast Cancer Screening: a Randomised Controlled Trial." Lancet (London, England), vol. 385, no. 9978, 2015, pp. 1642-52.
Hersch J, Barratt A, Jansen J, et al. Use of a decision aid including information on overdetection to support informed choice about breast cancer screening: a randomised controlled trial. Lancet. 2015;385(9978):1642-52.
Hersch, J., Barratt, A., Jansen, J., Irwig, L., McGeechan, K., Jacklyn, G., ... McCaffery, K. (2015). Use of a decision aid including information on overdetection to support informed choice about breast cancer screening: a randomised controlled trial. Lancet (London, England), 385(9978), pp. 1642-52. doi:10.1016/S0140-6736(15)60123-4.
Hersch J, et al. Use of a Decision Aid Including Information On Overdetection to Support Informed Choice About Breast Cancer Screening: a Randomised Controlled Trial. Lancet. 2015 Apr 25;385(9978):1642-52. PubMed PMID: 25701273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of a decision aid including information on overdetection to support informed choice about breast cancer screening: a randomised controlled trial. AU - Hersch,Jolyn, AU - Barratt,Alexandra, AU - Jansen,Jesse, AU - Irwig,Les, AU - McGeechan,Kevin, AU - Jacklyn,Gemma, AU - Thornton,Hazel, AU - Dhillon,Haryana, AU - Houssami,Nehmat, AU - McCaffery,Kirsten, Y1 - 2015/02/18/ PY - 2015/2/22/entrez PY - 2015/2/24/pubmed PY - 2015/7/21/medline SP - 1642 EP - 52 JF - Lancet (London, England) JO - Lancet VL - 385 IS - 9978 N2 - BACKGROUND: Mammography screening can reduce breast cancer mortality. However, most women are unaware that inconsequential disease can also be detected by screening, leading to overdiagnosis and overtreatment. We aimed to investigate whether including information about overdetection of breast cancer in a decision aid would help women aged around 50 years to make an informed choice about breast screening. METHODS: We did a community-based, parallel-group, randomised controlled trial in New South Wales, Australia, using a random cohort of women aged 48-50 years. Recruitment to the study was done by telephone; women were eligible if they had not had mammography in the past 2 years and did not have a personal or strong family history of breast cancer. With a computer program, we randomly assigned 879 participants to either the intervention decision aid (comprising evidence-based explanatory and quantitative information on overdetection, breast cancer mortality reduction, and false positives) or a control decision aid (including information on breast cancer mortality reduction and false positives). Participants and interviewers were masked to group assignment. The primary outcome was informed choice (defined as adequate knowledge and consistency between attitudes and screening intentions), which we assessed by telephone interview about 3 weeks after random allocation. The primary outcome was analysed in all women who completed the relevant follow-up interview questions fully. This trial is registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12613001035718. FINDINGS: Between January, 2014, and July, 2014, 440 women were allocated to the intervention group and 439 were assigned to the control group. 21 women in the intervention group and 20 controls were lost to follow-up; a further ten women assigned to the intervention and 11 controls did not answer all questions on attitudes. Therefore, 409 women in the intervention group and 408 controls were analysed for the primary outcome. 99 (24%) of 409 women in the intervention group made an informed choice compared with 63 (15%) of 408 in the control group (difference 9%, 95% CI 3-14; p=0·0017). Compared with controls, more women in the intervention group met the threshold for adequate overall knowledge (122/419 [29%] vs 71/419 [17%]; difference 12%, 95% CI 6-18; p<0·0001), fewer women expressed positive attitudes towards screening (282/409 [69%] vs 340/408 [83%]; 14%, 9-20; p<0·0001), and fewer women intended to be screened (308/419 [74%] vs 363/419 [87%]; 13%, 8-19; p<0·0001). When conceptual knowledge alone was considered, 203 (50%) of 409 women in the intervention group made an informed choice compared with 79 (19%) of 408 in the control group (p<0·0001). INTERPRETATION: Information on overdetection of breast cancer provided within a decision aid increased the number of women making an informed choice about breast screening. Becoming better informed might mean women are less likely to choose screening. FUNDING: Australian National Health and Medical Research Council. SN - 1474-547X UR - https://wwww.unboundmedicine.com/medline/citation/25701273/Use_of_a_decision_aid_including_information_on_overdetection_to_support_informed_choice_about_breast_cancer_screening:_a_randomised_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(15)60123-4 DB - PRIME DP - Unbound Medicine ER -