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Impact of bilirubin-induced neurologic dysfunction on neurodevelopmental outcomes.
Semin Fetal Neonatal Med. 2015 Feb; 20(1):52-57.SF

Abstract

Bilirubin-induced neurologic dysfunction (BIND) is the constellation of neurologic sequelae following milder degrees of neonatal hyperbilirubinemia than are associated with kernicterus. Clinically, BIND may manifest after the neonatal period as developmental delay, cognitive impairment, disordered executive function, and behavioral and psychiatric disorders. However, there is controversy regarding the relative contribution of neonatal hyperbilirubinemia versus other risk factors to the development of later neurodevelopmental disorders in children with BIND. In this review, we focus on the empiric data from the past 25 years regarding neurodevelopmental outcomes and BIND, including specific effects on developmental delay, cognition, speech and language development, executive function, and the neurobehavioral disorders, such as attention deficit/hyperactivity disorder and autism.

Authors+Show Affiliations

Division of Child Neurology, Stanford University School of Medicine, Palo Alto, CA, USA. Electronic address: wusthoff@stanford.edu.Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

25585889

Citation

Wusthoff, Courtney J., and Irene M. Loe. "Impact of Bilirubin-induced Neurologic Dysfunction On Neurodevelopmental Outcomes." Seminars in Fetal & Neonatal Medicine, vol. 20, no. 1, 2015, pp. 52-57.
Wusthoff CJ, Loe IM. Impact of bilirubin-induced neurologic dysfunction on neurodevelopmental outcomes. Semin Fetal Neonatal Med. 2015;20(1):52-57.
Wusthoff, C. J., & Loe, I. M. (2015). Impact of bilirubin-induced neurologic dysfunction on neurodevelopmental outcomes. Seminars in Fetal & Neonatal Medicine, 20(1), 52-57. https://doi.org/10.1016/j.siny.2014.12.003
Wusthoff CJ, Loe IM. Impact of Bilirubin-induced Neurologic Dysfunction On Neurodevelopmental Outcomes. Semin Fetal Neonatal Med. 2015;20(1):52-57. PubMed PMID: 25585889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of bilirubin-induced neurologic dysfunction on neurodevelopmental outcomes. AU - Wusthoff,Courtney J, AU - Loe,Irene M, Y1 - 2015/01/10/ PY - 2015/1/15/entrez PY - 2015/1/15/pubmed PY - 2016/1/1/medline KW - Cognition KW - Developmental disabilities KW - Hyperbilirubinemia KW - Neonate KW - Outcomes SP - 52 EP - 57 JF - Seminars in fetal & neonatal medicine JO - Semin Fetal Neonatal Med VL - 20 IS - 1 N2 - Bilirubin-induced neurologic dysfunction (BIND) is the constellation of neurologic sequelae following milder degrees of neonatal hyperbilirubinemia than are associated with kernicterus. Clinically, BIND may manifest after the neonatal period as developmental delay, cognitive impairment, disordered executive function, and behavioral and psychiatric disorders. However, there is controversy regarding the relative contribution of neonatal hyperbilirubinemia versus other risk factors to the development of later neurodevelopmental disorders in children with BIND. In this review, we focus on the empiric data from the past 25 years regarding neurodevelopmental outcomes and BIND, including specific effects on developmental delay, cognition, speech and language development, executive function, and the neurobehavioral disorders, such as attention deficit/hyperactivity disorder and autism. SN - 1878-0946 UR - https://wwww.unboundmedicine.com/medline/citation/25585889/Impact_of_bilirubin_induced_neurologic_dysfunction_on_neurodevelopmental_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1744-165X(14)00098-5 DB - PRIME DP - Unbound Medicine ER -