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Impact of Rhesus disease on the global problem of bilirubin-induced neurologic dysfunction.
Semin Fetal Neonatal Med. 2015 Feb; 20(1):2-5.SF

Abstract

Clinical experience with Rhesus (Rh) disease and its post-icteric sequelae is limited among high-income countries because of nearly over four decades of effective prevention care. We hypothesized that Rh disease is prevalent in other regions of the world because it is likely that protection is limited or non-existent. Following a worldwide study, it has been concluded that Rh hemolytic disease is a significant public health problem resulting in stillbirths and neonatal deaths, and is a major cause of severe hyperbilirubinemia with its sequelae, kernicterus and bilirubin-induced neurologic dysfunction. Knowing that effective Rh-disease prophylaxis depends on maternal blood-type screening, healthcare afforded to the high-risk mothers needs to be free of bottlenecks and coupled with unfettered access to effective Rh-immunoglobulin. Future studies that match the universal identification of Rh-negative status of women and targeted use of immunoprophylaxis to prevent childhood bilirubin neurotoxicity are within reach, based on vast prior experiences.

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Authors+Show Affiliations

Zipursky A
Centre for Global Child Health, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada.
Bhutani VK
Department of Pediatrics, Division of Neonatal‒Perinatal Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: bhutani@stanford.edu.

MeSH

BilirubinFemaleHumansHyperbilirubinemia, NeonatalInfant, NewbornKernicterusPregnancyRh Isoimmunization

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25582277

Clinical Trial Links

The Prevention of Rh Disease of Newborns in Pakistan

Citation

Zipursky, Alvin, and Vinod K. Bhutani. "Impact of Rhesus Disease On the Global Problem of Bilirubin-induced Neurologic Dysfunction." Seminars in Fetal & Neonatal Medicine, vol. 20, no. 1, 2015, pp. 2-5.
Zipursky A, Bhutani VK. Impact of Rhesus disease on the global problem of bilirubin-induced neurologic dysfunction. Semin Fetal Neonatal Med. 2015;20(1):2-5.
Zipursky, A., & Bhutani, V. K. (2015). Impact of Rhesus disease on the global problem of bilirubin-induced neurologic dysfunction. Seminars in Fetal & Neonatal Medicine, 20(1), 2-5. https://doi.org/10.1016/j.siny.2014.12.001
Zipursky A, Bhutani VK. Impact of Rhesus Disease On the Global Problem of Bilirubin-induced Neurologic Dysfunction. Semin Fetal Neonatal Med. 2015;20(1):2-5. PubMed PMID: 25582277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Rhesus disease on the global problem of bilirubin-induced neurologic dysfunction. AU - Zipursky,Alvin, AU - Bhutani,Vinod K, Y1 - 2015/01/09/ PY - 2015/1/14/entrez PY - 2015/1/15/pubmed PY - 2016/1/1/medline KW - Bilirubin KW - Bilirubin-induced neurologic dysfunction (BIND) KW - Minor neurologic dysfunction KW - Rhesus disease KW - Subtle bilirubin injury SP - 2 EP - 5 JF - Seminars in fetal & neonatal medicine JO - Semin Fetal Neonatal Med VL - 20 IS - 1 N2 - Clinical experience with Rhesus (Rh) disease and its post-icteric sequelae is limited among high-income countries because of nearly over four decades of effective prevention care. We hypothesized that Rh disease is prevalent in other regions of the world because it is likely that protection is limited or non-existent. Following a worldwide study, it has been concluded that Rh hemolytic disease is a significant public health problem resulting in stillbirths and neonatal deaths, and is a major cause of severe hyperbilirubinemia with its sequelae, kernicterus and bilirubin-induced neurologic dysfunction. Knowing that effective Rh-disease prophylaxis depends on maternal blood-type screening, healthcare afforded to the high-risk mothers needs to be free of bottlenecks and coupled with unfettered access to effective Rh-immunoglobulin. Future studies that match the universal identification of Rh-negative status of women and targeted use of immunoprophylaxis to prevent childhood bilirubin neurotoxicity are within reach, based on vast prior experiences. SN - 1878-0946 UR - https://wwww.unboundmedicine.com/medline/citation/25582277/Impact_of_Rhesus_disease_on_the_global_problem_of_bilirubin_induced_neurologic_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1744-165X(14)00096-1 DB - PRIME DP - Unbound Medicine ER -