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Audiologic impairment associated with bilirubin-induced neurologic damage.
Semin Fetal Neonatal Med. 2015 Feb; 20(1):42-46.SF

Abstract

Hyperbilirubinemia occurs commonly in neonates and is usually mild and transient, with no long-lasting sequelae. However, bilirubin-induced neurologic damage may occur in some infants. The auditory pathway is the most sensitive part of the central nervous system to bilirubin-induced toxicity, and permanent sequelae may result from only moderately elevated total serum/plasma bilirubin levels. The damage to the auditory system occurs primarily within the brainstem and cranial nerve VIII, and manifests clinically as auditory neuropathy spectrum disorder.

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Authors+Show Affiliations

Olds C
Department of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305-5739, USA.
Oghalai JS
Department of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305-5739, USA. Electronic address: joghalai@stanford.edu.

MeSH

Evoked Potentials, Auditory, Brain StemHearing DisordersHumansHyperbilirubinemia, NeonatalInfant, NewbornKernicterus

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25575899

Citation

Olds, Cristen, and John S. Oghalai. "Audiologic Impairment Associated With Bilirubin-induced Neurologic Damage." Seminars in Fetal & Neonatal Medicine, vol. 20, no. 1, 2015, pp. 42-46.
Olds C, Oghalai JS. Audiologic impairment associated with bilirubin-induced neurologic damage. Semin Fetal Neonatal Med. 2015;20(1):42-46.
Olds, C., & Oghalai, J. S. (2015). Audiologic impairment associated with bilirubin-induced neurologic damage. Seminars in Fetal & Neonatal Medicine, 20(1), 42-46. https://doi.org/10.1016/j.siny.2014.12.006
Olds C, Oghalai JS. Audiologic Impairment Associated With Bilirubin-induced Neurologic Damage. Semin Fetal Neonatal Med. 2015;20(1):42-46. PubMed PMID: 25575899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Audiologic impairment associated with bilirubin-induced neurologic damage. AU - Olds,Cristen, AU - Oghalai,John S, Y1 - 2015/01/07/ PY - 2015/1/11/entrez PY - 2015/1/13/pubmed PY - 2016/1/1/medline KW - Auditory brainstem response KW - Auditory neuropathy KW - Bilirubin KW - Hyperbilirubinemia KW - Kernicterus SP - 42 EP - 46 JF - Seminars in fetal & neonatal medicine JO - Semin Fetal Neonatal Med VL - 20 IS - 1 N2 - Hyperbilirubinemia occurs commonly in neonates and is usually mild and transient, with no long-lasting sequelae. However, bilirubin-induced neurologic damage may occur in some infants. The auditory pathway is the most sensitive part of the central nervous system to bilirubin-induced toxicity, and permanent sequelae may result from only moderately elevated total serum/plasma bilirubin levels. The damage to the auditory system occurs primarily within the brainstem and cranial nerve VIII, and manifests clinically as auditory neuropathy spectrum disorder. SN - 1878-0946 UR - https://wwww.unboundmedicine.com/medline/citation/25575899/Audiologic_impairment_associated_with_bilirubin_induced_neurologic_damage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1744-165X(14)00101-2 DB - PRIME DP - Unbound Medicine ER -