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A prospective, randomized, single - blind study comparing intraplaque injection of thiocolchicine and verapamil in Peyronie's Disease: a pilot study.
Int Braz J Urol. 2016 Sep-Oct; 42(5):1005-1009.IB

Abstract

OBJECTIVES

To compare the response to tiocolchicine and verapamil injection in the plaque of patients with Peyronie's disease.

MATERIALS AND METHODS

Prospective, single-blind, randomized study, selecting patients who have presented Peyronie's disease for less than 18 months. Thiocolchicine 4mg or verapamil 5mg were given in 7 injections (once a week). Patients who had received any treatment for Peyronie's disease in the past three months were excluded. The parameters used were the International Index of Erectile Function (IIEF-5) score, analysis of the curvature on pharmaco-induced erections and size of the plaque by ultrasonography.

RESULTS

Twenty-five patients were randomized, 13 received thiocolchicine and 12 were treated with verapamil. Both groups were statistically similar. The mean curvature was 46.7º and 36.2º before and after thiocolchicine, respectively (p=0.019) and 50.4º and 42.08º before and after verapamil, respectively (p=0.012). The curvature improved in 69% of patients treated with thiocolchicine and in 66% of those who received verapamil. Regarding sexual function, there was an increase in the IIEF-5 from 16.69 to 20.85 (p=0.23) in the thiocolchicine group. In the verapamil group the IIEF-5 score dropped from 17.50 to 16.25 (p=0.58). In the thiocolchicine group, the plaque was reduced in 61% of patients. In the verapamil group, 8% presented decreased plaque size. No adverse event was associated to thiocolchicine.

CONCLUSION

The use of thiocolchicine in Peyronie's disease demonstrated improvement on penile curvature and reduction in plaque size. Thiocolchicine presented similar results to verapamil in curvature assessment. No significant side effects were observed with the use of tiocolchicine.

Authors+Show Affiliations

Departamento de Urologia, Hospital Ipiranga, São Paulo, Brasil.Departamento de Urologia, Hospital Ipiranga, São Paulo, Brasil.Departamento de Urologia, Hospital Ipiranga, São Paulo, Brasil.Departamento de Urologia, Hospital Ipiranga, São Paulo, Brasil.Departamento de Urologia, Hospital Ipiranga, São Paulo, Brasil.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24893912

Citation

Toscano, L, et al. "A Prospective, Randomized, Single - Blind Study Comparing Intraplaque Injection of Thiocolchicine and Verapamil in Peyronie's Disease: a Pilot Study." International Braz J Urol : Official Journal of the Brazilian Society of Urology, vol. 42, no. 5, 2016, pp. 1005-1009.
Toscano L, Rezende MV, Mello LF, et al. A prospective, randomized, single - blind study comparing intraplaque injection of thiocolchicine and verapamil in Peyronie's Disease: a pilot study. Int Braz J Urol. 2016;42(5):1005-1009.
Toscano, L., Rezende, M. V., Mello, L. F., Paulillo, D., & Glina, S. (2016). A prospective, randomized, single - blind study comparing intraplaque injection of thiocolchicine and verapamil in Peyronie's Disease: a pilot study. International Braz J Urol : Official Journal of the Brazilian Society of Urology, 42(5), 1005-1009. https://doi.org/10.1590/S1677-5538.IBJU.2015.0598
Toscano L, et al. A Prospective, Randomized, Single - Blind Study Comparing Intraplaque Injection of Thiocolchicine and Verapamil in Peyronie's Disease: a Pilot Study. Int Braz J Urol. 2016 Sep-Oct;42(5):1005-1009. PubMed PMID: 24893912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective, randomized, single - blind study comparing intraplaque injection of thiocolchicine and verapamil in Peyronie's Disease: a pilot study. AU - Toscano,L,Jr AU - Rezende,M V, AU - Mello,L F, AU - Paulillo,D, AU - Glina,S, PY - 2016/02/24/received PY - 2016/03/21/accepted PY - 2016/10/21/pubmed PY - 2017/6/29/medline PY - 2014/6/5/entrez KW - Penile Induration KW - Penis KW - Verapamil SP - 1005 EP - 1009 JF - International braz j urol : official journal of the Brazilian Society of Urology JO - Int Braz J Urol VL - 42 IS - 5 N2 - OBJECTIVES: To compare the response to tiocolchicine and verapamil injection in the plaque of patients with Peyronie's disease. MATERIALS AND METHODS: Prospective, single-blind, randomized study, selecting patients who have presented Peyronie's disease for less than 18 months. Thiocolchicine 4mg or verapamil 5mg were given in 7 injections (once a week). Patients who had received any treatment for Peyronie's disease in the past three months were excluded. The parameters used were the International Index of Erectile Function (IIEF-5) score, analysis of the curvature on pharmaco-induced erections and size of the plaque by ultrasonography. RESULTS: Twenty-five patients were randomized, 13 received thiocolchicine and 12 were treated with verapamil. Both groups were statistically similar. The mean curvature was 46.7º and 36.2º before and after thiocolchicine, respectively (p=0.019) and 50.4º and 42.08º before and after verapamil, respectively (p=0.012). The curvature improved in 69% of patients treated with thiocolchicine and in 66% of those who received verapamil. Regarding sexual function, there was an increase in the IIEF-5 from 16.69 to 20.85 (p=0.23) in the thiocolchicine group. In the verapamil group the IIEF-5 score dropped from 17.50 to 16.25 (p=0.58). In the thiocolchicine group, the plaque was reduced in 61% of patients. In the verapamil group, 8% presented decreased plaque size. No adverse event was associated to thiocolchicine. CONCLUSION: The use of thiocolchicine in Peyronie's disease demonstrated improvement on penile curvature and reduction in plaque size. Thiocolchicine presented similar results to verapamil in curvature assessment. No significant side effects were observed with the use of tiocolchicine. SN - 1677-6119 UR - https://wwww.unboundmedicine.com/medline/citation/24893912/A_prospective_randomized_single___blind_study_comparing_intraplaque_injection_of_thiocolchicine_and_verapamil_in_Peyronie's_Disease:_a_pilot_study_ DB - PRIME DP - Unbound Medicine ER -