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The pivotal sign of CANVAS.
Neurology. 2013 Oct 29; 81(18):1642-3.Neur

Abstract

A 75-year-old woman complained about insecure gait since age 55. Clinical examination revealed signs of cerebellar ataxia, bilateral vestibulopathy, and peripheral sensory impairment. Sensory nerve action potentials were absent. The visually enhanced vestibulo-ocular reflex (VVOR) was impaired (video on the Neurology(®) Web site at www.neurology.org, figure 1) and the diagnosis of cerebellar ataxia (figure 2) with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) was made.(1) CANVAS is considered to be a recessive disorder with a mean age at onset of 60 years.(2) VVOR impairment is its characteristic clinical sign.(2) It can only be elicited if both smooth-pursuit eye movements and the vestibulo-ocular reflex are deficient. Normally, both are redundant at low head velocities.(2.)

Authors+Show Affiliations

From the Departments of Neurology (J.A.P., K.P.W.), Neuroradiology (W.W.W.), and Ophthalmology (K.P.W.), University Hospital Zurich, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Video-Audio Media

Language

eng

PubMed ID

24166963

Citation

Petersen, Jens Alexander, et al. "The Pivotal Sign of CANVAS." Neurology, vol. 81, no. 18, 2013, pp. 1642-3.
Petersen JA, Wichmann WW, Weber KP. The pivotal sign of CANVAS. Neurology. 2013;81(18):1642-3.
Petersen, J. A., Wichmann, W. W., & Weber, K. P. (2013). The pivotal sign of CANVAS. Neurology, 81(18), 1642-3. https://doi.org/10.1212/WNL.0b013e3182a9f435
Petersen JA, Wichmann WW, Weber KP. The Pivotal Sign of CANVAS. Neurology. 2013 Oct 29;81(18):1642-3. PubMed PMID: 24166963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The pivotal sign of CANVAS. AU - Petersen,Jens Alexander, AU - Wichmann,Werner W, AU - Weber,Konrad Peter, PY - 2013/10/30/entrez PY - 2013/10/30/pubmed PY - 2013/12/18/medline SP - 1642 EP - 3 JF - Neurology JO - Neurology VL - 81 IS - 18 N2 - A 75-year-old woman complained about insecure gait since age 55. Clinical examination revealed signs of cerebellar ataxia, bilateral vestibulopathy, and peripheral sensory impairment. Sensory nerve action potentials were absent. The visually enhanced vestibulo-ocular reflex (VVOR) was impaired (video on the Neurology(®) Web site at www.neurology.org, figure 1) and the diagnosis of cerebellar ataxia (figure 2) with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) was made.(1) CANVAS is considered to be a recessive disorder with a mean age at onset of 60 years.(2) VVOR impairment is its characteristic clinical sign.(2) It can only be elicited if both smooth-pursuit eye movements and the vestibulo-ocular reflex are deficient. Normally, both are redundant at low head velocities.(2.) SN - 1526-632X UR - https://wwww.unboundmedicine.com/medline/citation/24166963/The_pivotal_sign_of_CANVAS_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=24166963 DB - PRIME DP - Unbound Medicine ER -