Tags

Type your tag names separated by a space and hit enter

The effects of Panax notoginseng on delayed onset muscle soreness and muscle damage in well-trained males: a double blind randomised controlled trial.
Complement Ther Med. 2013 Jun; 21(3):131-40.CT

Abstract

OBJECTIVES

The aim of the study was to determine if Panax notoginseng is effective in reducing pain, indicators of inflammation and muscle damage, and in turn improve performance in well trained males who underwent a bout of eccentric exercise designed to induce delayed onset muscle soreness (DOMS).

DESIGN

A double blind randomised placebo controlled trial.

SETTING

Twenty well trained male volunteers, matched by maximum aerobic capacity were randomly assigned to consume a regime of 4000 mg of P. notoginseng capsules or an indistinguishable placebo before and after a downhill treadmill running episode designed to induce DOMS.

MAIN OUTCOME MEASURES

Performance measures (Kin-Com, counter movement and squat jump), pain assessments (visual analogue scale (VAS), algometer) and blood analyses (interleukin-1, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), C-reactive protein, myoglobin, creatine kinase) were assessed at 7 time points over 5 days (pre, post, 4, 24, 48, 72 and 96 h after the downhill run).

RESULTS

The placebo group demonstrated a significant decrease in squat jump performance immediately post the downhill run, with a mean change ± 95% confidence interval (CI) of 0.8 cm (-3.53 to 1.93). The placebo group also experienced increased pain in the quadriceps 96 h after the downhill run, with a mean VAS change ± 95% CI of -0.32 cm (-0.34 to 0.98).The serum concentration of IL-6 and TNF-α were significantly lower in the placebo group 24h after the downhill run. Mean IL-6 change ± 95% CI of 0.50 pg/mL (-1.59 to 0.59), and mean TNF-α change ± 95% CI was 0.98 pg/mL (-2.04 to 0.09). No other significant differences were identified between the groups for any other outcome measure.

CONCLUSION

Considering all data from this study, P. notoginseng did not convincingly have an effect on performance, muscular pain or assessed blood markers in well-trained males after an intense bout of eccentric exercise that induced DOMS.

Authors+Show Affiliations

National Institute of Sport Studies, University of Canberra, Canberra, Australia. Kate.Pumpa@canberra.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23642942

Citation

Pumpa, Kate L., et al. "The Effects of Panax Notoginseng On Delayed Onset Muscle Soreness and Muscle Damage in Well-trained Males: a Double Blind Randomised Controlled Trial." Complementary Therapies in Medicine, vol. 21, no. 3, 2013, pp. 131-40.
Pumpa KL, Fallon KE, Bensoussan A, et al. The effects of Panax notoginseng on delayed onset muscle soreness and muscle damage in well-trained males: a double blind randomised controlled trial. Complement Ther Med. 2013;21(3):131-40.
Pumpa, K. L., Fallon, K. E., Bensoussan, A., & Papalia, S. (2013). The effects of Panax notoginseng on delayed onset muscle soreness and muscle damage in well-trained males: a double blind randomised controlled trial. Complementary Therapies in Medicine, 21(3), 131-40. https://doi.org/10.1016/j.ctim.2012.12.007
Pumpa KL, et al. The Effects of Panax Notoginseng On Delayed Onset Muscle Soreness and Muscle Damage in Well-trained Males: a Double Blind Randomised Controlled Trial. Complement Ther Med. 2013;21(3):131-40. PubMed PMID: 23642942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of Panax notoginseng on delayed onset muscle soreness and muscle damage in well-trained males: a double blind randomised controlled trial. AU - Pumpa,Kate L, AU - Fallon,Kieran E, AU - Bensoussan,Alan, AU - Papalia,Shona, Y1 - 2013/01/05/ PY - 2011/10/20/received PY - 2012/12/10/revised PY - 2012/12/11/accepted PY - 2013/5/7/entrez PY - 2013/5/7/pubmed PY - 2013/10/22/medline SP - 131 EP - 40 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 21 IS - 3 N2 - OBJECTIVES: The aim of the study was to determine if Panax notoginseng is effective in reducing pain, indicators of inflammation and muscle damage, and in turn improve performance in well trained males who underwent a bout of eccentric exercise designed to induce delayed onset muscle soreness (DOMS). DESIGN: A double blind randomised placebo controlled trial. SETTING: Twenty well trained male volunteers, matched by maximum aerobic capacity were randomly assigned to consume a regime of 4000 mg of P. notoginseng capsules or an indistinguishable placebo before and after a downhill treadmill running episode designed to induce DOMS. MAIN OUTCOME MEASURES: Performance measures (Kin-Com, counter movement and squat jump), pain assessments (visual analogue scale (VAS), algometer) and blood analyses (interleukin-1, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), C-reactive protein, myoglobin, creatine kinase) were assessed at 7 time points over 5 days (pre, post, 4, 24, 48, 72 and 96 h after the downhill run). RESULTS: The placebo group demonstrated a significant decrease in squat jump performance immediately post the downhill run, with a mean change ± 95% confidence interval (CI) of 0.8 cm (-3.53 to 1.93). The placebo group also experienced increased pain in the quadriceps 96 h after the downhill run, with a mean VAS change ± 95% CI of -0.32 cm (-0.34 to 0.98).The serum concentration of IL-6 and TNF-α were significantly lower in the placebo group 24h after the downhill run. Mean IL-6 change ± 95% CI of 0.50 pg/mL (-1.59 to 0.59), and mean TNF-α change ± 95% CI was 0.98 pg/mL (-2.04 to 0.09). No other significant differences were identified between the groups for any other outcome measure. CONCLUSION: Considering all data from this study, P. notoginseng did not convincingly have an effect on performance, muscular pain or assessed blood markers in well-trained males after an intense bout of eccentric exercise that induced DOMS. SN - 1873-6963 UR - https://wwww.unboundmedicine.com/medline/citation/23642942/The_effects_of_Panax_notoginseng_on_delayed_onset_muscle_soreness_and_muscle_damage_in_well_trained_males:_a_double_blind_randomised_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(12)00173-2 DB - PRIME DP - Unbound Medicine ER -