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A retrospective review of isolated duloxetine-exposure cases.
Clin Toxicol (Phila). 2013 Feb; 51(2):106-10.CT

Abstract

BACKGROUND

Duloxetine is a serotonin norepinephrine reuptake inhibitor (SNRI) approved in the US for the treatment of major depression, generalized anxiety, fibromyalgia, diabetic peripheral neuropathy, and chronic musculoskeletal pain. Given the limited published information regarding human overdoses to this medication, our goal was to characterize such exposures.

METHODS

We retrospectively reviewed a state poison system's database for all single agent exposures to duloxetine from 2004-2011. Data collected included age, gender, circumstances surrounding exposure, symptoms, and outcome. Patients with co-ingestants, confirmed non-exposure, unknown outcomes, or other coding errors were excluded.

RESULTS

159 cases were identified. 106 were included for review. Of 61 pediatric and adolescent cases (0-19 years old) identified, 53 involved unintentional overdose. Three patients experienced symptoms and none were admitted. All intentional ingestions(8) were seen in the emergency department, two patients experienced symptoms. No intentional ingestion was admitted for medical care. Fifty-one adult cases were included for review. Four adult patients were admitted following intentional duloxetine overdose with resolution of symptoms within 24 hours. Three adults were evaluated in a HCF following non-self-harm exposures to duloxetine. None of these patients were admitted. The remaining 15 adult patients with non-self-harm exposures were safely managed at home.

CONCLUSION

The majority of non-self-harm duloxetine-exposed adult and pediatric/adolescent patients were safely managed at home and when evaluated in a healthcare facility, did not require further hospitalization. Intentional pediatric/adolescent and adult duloxetine exposures were managed in a healthcare facility but rarely resulted in further hospitalization, serious morbidity, or mortality.

Authors+Show Affiliations

California Poison Control System, San Diego Division, San Diego, CA, USA. mdarracq@ucsd.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23356816

Citation

Darracq, Michael A., et al. "A Retrospective Review of Isolated Duloxetine-exposure Cases." Clinical Toxicology (Philadelphia, Pa.), vol. 51, no. 2, 2013, pp. 106-10.
Darracq MA, Clark A, Qian L, et al. A retrospective review of isolated duloxetine-exposure cases. Clin Toxicol (Phila). 2013;51(2):106-10.
Darracq, M. A., Clark, A., Qian, L., & Cantrell, F. L. (2013). A retrospective review of isolated duloxetine-exposure cases. Clinical Toxicology (Philadelphia, Pa.), 51(2), 106-10. https://doi.org/10.3109/15563650.2013.766749
Darracq MA, et al. A Retrospective Review of Isolated Duloxetine-exposure Cases. Clin Toxicol (Phila). 2013;51(2):106-10. PubMed PMID: 23356816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A retrospective review of isolated duloxetine-exposure cases. AU - Darracq,Michael A, AU - Clark,Alycia, AU - Qian,Lily, AU - Cantrell,F Lee, Y1 - 2013/01/29/ PY - 2013/1/30/entrez PY - 2013/1/30/pubmed PY - 2013/4/3/medline SP - 106 EP - 10 JF - Clinical toxicology (Philadelphia, Pa.) JO - Clin Toxicol (Phila) VL - 51 IS - 2 N2 - BACKGROUND: Duloxetine is a serotonin norepinephrine reuptake inhibitor (SNRI) approved in the US for the treatment of major depression, generalized anxiety, fibromyalgia, diabetic peripheral neuropathy, and chronic musculoskeletal pain. Given the limited published information regarding human overdoses to this medication, our goal was to characterize such exposures. METHODS: We retrospectively reviewed a state poison system's database for all single agent exposures to duloxetine from 2004-2011. Data collected included age, gender, circumstances surrounding exposure, symptoms, and outcome. Patients with co-ingestants, confirmed non-exposure, unknown outcomes, or other coding errors were excluded. RESULTS: 159 cases were identified. 106 were included for review. Of 61 pediatric and adolescent cases (0-19 years old) identified, 53 involved unintentional overdose. Three patients experienced symptoms and none were admitted. All intentional ingestions(8) were seen in the emergency department, two patients experienced symptoms. No intentional ingestion was admitted for medical care. Fifty-one adult cases were included for review. Four adult patients were admitted following intentional duloxetine overdose with resolution of symptoms within 24 hours. Three adults were evaluated in a HCF following non-self-harm exposures to duloxetine. None of these patients were admitted. The remaining 15 adult patients with non-self-harm exposures were safely managed at home. CONCLUSION: The majority of non-self-harm duloxetine-exposed adult and pediatric/adolescent patients were safely managed at home and when evaluated in a healthcare facility, did not require further hospitalization. Intentional pediatric/adolescent and adult duloxetine exposures were managed in a healthcare facility but rarely resulted in further hospitalization, serious morbidity, or mortality. SN - 1556-9519 UR - https://wwww.unboundmedicine.com/medline/citation/23356816/A_retrospective_review_of_isolated_duloxetine_exposure_cases_ L2 - https://www.tandfonline.com/doi/full/10.3109/15563650.2013.766749 DB - PRIME DP - Unbound Medicine ER -