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[Protective effects of metaprot and ethomerzol in carbophos intoxications].

Abstract

The mechanisms of protective action of thiobenzimidazole derivatives metaprot and ethomerzol (25 and 50 mg/kg) have been studied on a model of carbophos intoxication (256.0 +/- 8.7 mg/kg) in rats. Both compounds recovered the resistance to physical loads in forced swimming test, normalized the activity of aspartate and alanine transaminases, and reduced bilirubin, creatinine, and urea nitrogen levels in the blood serum. The intoxication was accompanied with increasing concentration of malonic dialdehyde and decreasing level of recovered glutation in the blood, as well as with the signs of endogenic intoxication. Metaprot and ethomerzol diminished disorders of both the lipid peroxidation and endogenic intoxication processes. Thus, the antihypoxic, antioxidant, actoprotective, energotropic, and reparative effects of metaprot and ethomerzol have been proved. Ethomerzol was more effective than metaprot in these tests.

Authors

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Source

MeSH

Alanine Transaminase
Animals
Antioxidants
Aspartate Aminotransferases
Benzimidazoles
Bilirubin
Blood Urea Nitrogen
Creatinine
Dose-Response Relationship, Drug
Glutathione
Insecticides
Lipid Peroxidation
Liver
Malathion
Male
Malondialdehyde
Rats
Rats, Wistar
Swimming

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

23012992

Citation

Vorob'eva, V V., et al. "[Protective Effects of Metaprot and Ethomerzol in Carbophos Intoxications]." Eksperimental'naia I Klinicheskaia Farmakologiia, vol. 75, no. 8, 2012, pp. 25-30.
Vorob'eva VV, Zarubina IV, Shabanov PD. [Protective effects of metaprot and ethomerzol in carbophos intoxications]. Eksp Klin Farmakol. 2012;75(8):25-30.
Vorob'eva, V. V., Zarubina, I. V., & Shabanov, P. D. (2012). [Protective effects of metaprot and ethomerzol in carbophos intoxications]. Eksperimental'naia I Klinicheskaia Farmakologiia, 75(8), pp. 25-30.
Vorob'eva VV, Zarubina IV, Shabanov PD. [Protective Effects of Metaprot and Ethomerzol in Carbophos Intoxications]. Eksp Klin Farmakol. 2012;75(8):25-30. PubMed PMID: 23012992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Protective effects of metaprot and ethomerzol in carbophos intoxications]. AU - Vorob'eva,V V, AU - Zarubina,I V, AU - Shabanov,P D, PY - 2012/9/28/entrez PY - 2012/9/28/pubmed PY - 2012/12/14/medline SP - 25 EP - 30 JF - Eksperimental'naia i klinicheskaia farmakologiia JO - Eksp Klin Farmakol VL - 75 IS - 8 N2 - The mechanisms of protective action of thiobenzimidazole derivatives metaprot and ethomerzol (25 and 50 mg/kg) have been studied on a model of carbophos intoxication (256.0 +/- 8.7 mg/kg) in rats. Both compounds recovered the resistance to physical loads in forced swimming test, normalized the activity of aspartate and alanine transaminases, and reduced bilirubin, creatinine, and urea nitrogen levels in the blood serum. The intoxication was accompanied with increasing concentration of malonic dialdehyde and decreasing level of recovered glutation in the blood, as well as with the signs of endogenic intoxication. Metaprot and ethomerzol diminished disorders of both the lipid peroxidation and endogenic intoxication processes. Thus, the antihypoxic, antioxidant, actoprotective, energotropic, and reparative effects of metaprot and ethomerzol have been proved. Ethomerzol was more effective than metaprot in these tests. SN - 0869-2092 UR - https://wwww.unboundmedicine.com/medline/citation/23012992/[Protective_effects_of_metaprot_and_ethomerzol_in_carbophos_intoxications] L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -