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Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process.
Colloids Surf B Biointerfaces. 2012 Feb 01; 90:8-15.CS

Abstract

In the current study nano and microparticle engineering of water insoluble drugs was conducted using a novel piezoelectric spray-drying approach. Cyclosporin A (CyA) and dexamethasone (DEX) were encapsulated in biodegradable poly(D,L-lactide-co-glycolide) (PLGA) grades of different molecular weights. Spray-drying studies carried out with the Nano Spray Dryer B-90 employed with piezoelectric driven actuator. The processing parameters including inlet temperature, spray mesh diameter, sample flow rate, spray rate, applied pressure and sample concentration were examined in order to optimize the particle size and the obtained yield. The process parameters and the solute concentration showed a profound effect on the particle engineering and the obtained product yield. The produced powder presented consistent and reproducible spherical particles with narrow particle size distribution. Cyclosporin was found to be molecularly dispersed while dexamethasone was in crystalline state within the PLGA nanoparticles. Further evaluation revealed excellent drug loading, encapsulation efficiency and production yield. In vitro studies demonstrated sustained release patterns for the active substances. This novel spray-drying process proved to be efficient for nano and microparticle engineering of water insoluble active substances.

Authors+Show Affiliations

BÜCHI Labortechnik AG, Meierseggstrasse 40, 9230 Flawil, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22019455

Citation

Schafroth, Nina, et al. "Nano and Microparticle Engineering of Water Insoluble Drugs Using a Novel Spray-drying Process." Colloids and Surfaces. B, Biointerfaces, vol. 90, 2012, pp. 8-15.
Schafroth N, Arpagaus C, Jadhav UY, et al. Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process. Colloids Surf B Biointerfaces. 2012;90:8-15.
Schafroth, N., Arpagaus, C., Jadhav, U. Y., Makne, S., & Douroumis, D. (2012). Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process. Colloids and Surfaces. B, Biointerfaces, 90, 8-15. https://doi.org/10.1016/j.colsurfb.2011.09.038
Schafroth N, et al. Nano and Microparticle Engineering of Water Insoluble Drugs Using a Novel Spray-drying Process. Colloids Surf B Biointerfaces. 2012 Feb 1;90:8-15. PubMed PMID: 22019455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process. AU - Schafroth,Nina, AU - Arpagaus,Cordin, AU - Jadhav,Umesh Y, AU - Makne,Sushil, AU - Douroumis,Dennis, Y1 - 2011/10/04/ PY - 2011/06/17/received PY - 2011/09/10/revised PY - 2011/09/13/accepted PY - 2011/10/25/entrez PY - 2011/10/25/pubmed PY - 2012/3/15/medline SP - 8 EP - 15 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 90 N2 - In the current study nano and microparticle engineering of water insoluble drugs was conducted using a novel piezoelectric spray-drying approach. Cyclosporin A (CyA) and dexamethasone (DEX) were encapsulated in biodegradable poly(D,L-lactide-co-glycolide) (PLGA) grades of different molecular weights. Spray-drying studies carried out with the Nano Spray Dryer B-90 employed with piezoelectric driven actuator. The processing parameters including inlet temperature, spray mesh diameter, sample flow rate, spray rate, applied pressure and sample concentration were examined in order to optimize the particle size and the obtained yield. The process parameters and the solute concentration showed a profound effect on the particle engineering and the obtained product yield. The produced powder presented consistent and reproducible spherical particles with narrow particle size distribution. Cyclosporin was found to be molecularly dispersed while dexamethasone was in crystalline state within the PLGA nanoparticles. Further evaluation revealed excellent drug loading, encapsulation efficiency and production yield. In vitro studies demonstrated sustained release patterns for the active substances. This novel spray-drying process proved to be efficient for nano and microparticle engineering of water insoluble active substances. SN - 1873-4367 UR - https://wwww.unboundmedicine.com/medline/citation/22019455/Nano_and_microparticle_engineering_of_water_insoluble_drugs_using_a_novel_spray_drying_process_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(11)00561-3 DB - PRIME DP - Unbound Medicine ER -