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The clinical syndrome of bilirubin-induced neurologic dysfunction.
Semin Perinatol. 2011 Jun; 35(3):101-13.SP

Abstract

We believe that the syndrome of bilirubin-induced neurologic dysfunction [BIND] represents a spectrum of neurologic manifestations among vulnerable infants who have experienced an exposure to bilirubin of lesser degree than generally described in previous publications. Clinical neuro-motor manifestations extend to a range of subtle processing disorders with objective disturbances of visual-motor, auditory, speech, cognition, and language among infants with a previous history of moderate-to-severe hyperbilirubinemia of varied duration. Confounding effects include prematurity, hemolysis, perinatal-neonatal complications, altered bilirubin-albumin binding, severity and duration of bilirubin exposure, and the individual vulnerability of the infant related to genetic, family, social, and educational predilection, regardless of the cause of neonatal jaundice. Tools to better assess BIND specific domains of multisensory processing disorders, identified by pyschometric, audiologic, speech, language and visual-motor, and neuromotor examination would allow for prospective surveillance of infants at risk for the syndrome.

Authors+Show Affiliations

Pennsylvania Center for Kernicterus, Philadelphia, PA, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21641482

Citation

Johnson, Lois, and Vinod K. Bhutani. "The Clinical Syndrome of Bilirubin-induced Neurologic Dysfunction." Seminars in Perinatology, vol. 35, no. 3, 2011, pp. 101-13.
Johnson L, Bhutani VK. The clinical syndrome of bilirubin-induced neurologic dysfunction. Semin Perinatol. 2011;35(3):101-13.
Johnson, L., & Bhutani, V. K. (2011). The clinical syndrome of bilirubin-induced neurologic dysfunction. Seminars in Perinatology, 35(3), 101-13. https://doi.org/10.1053/j.semperi.2011.02.003
Johnson L, Bhutani VK. The Clinical Syndrome of Bilirubin-induced Neurologic Dysfunction. Semin Perinatol. 2011;35(3):101-13. PubMed PMID: 21641482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The clinical syndrome of bilirubin-induced neurologic dysfunction. AU - Johnson,Lois, AU - Bhutani,Vinod K, PY - 2011/6/7/entrez PY - 2011/6/7/pubmed PY - 2012/3/16/medline SP - 101 EP - 13 JF - Seminars in perinatology JO - Semin Perinatol VL - 35 IS - 3 N2 - We believe that the syndrome of bilirubin-induced neurologic dysfunction [BIND] represents a spectrum of neurologic manifestations among vulnerable infants who have experienced an exposure to bilirubin of lesser degree than generally described in previous publications. Clinical neuro-motor manifestations extend to a range of subtle processing disorders with objective disturbances of visual-motor, auditory, speech, cognition, and language among infants with a previous history of moderate-to-severe hyperbilirubinemia of varied duration. Confounding effects include prematurity, hemolysis, perinatal-neonatal complications, altered bilirubin-albumin binding, severity and duration of bilirubin exposure, and the individual vulnerability of the infant related to genetic, family, social, and educational predilection, regardless of the cause of neonatal jaundice. Tools to better assess BIND specific domains of multisensory processing disorders, identified by pyschometric, audiologic, speech, language and visual-motor, and neuromotor examination would allow for prospective surveillance of infants at risk for the syndrome. SN - 1558-075X UR - https://wwww.unboundmedicine.com/medline/citation/21641482/The_clinical_syndrome_of_bilirubin_induced_neurologic_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0146-0005(11)00032-2 DB - PRIME DP - Unbound Medicine ER -