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Effect of leucine supplementation on indices of muscle damage following drop jumps and resistance exercise.
Amino Acids. 2012 May; 42(5):1987-96.AA

Abstract

The purpose of this study was to determine the effect of leucine supplementation on indices of muscle damage following eccentric-based resistance exercise. In vitro, the amino acid leucine has been shown to reduce proteolysis and stimulate protein synthesis. Twenty-seven untrained males (height 178.6±5.5 cm; body mass 77.7±13.5 kg; age 21.3±1.6 years) were randomly divided into three groups; leucine (L) (n=10), placebo (P) (n=9) and control (C) (n=8). The two experimental groups (L and P) performed 100 depth jumps from 60 cm and six sets of ten repetitions of eccentric-only leg presses. Either leucine (250 mg/kg bm) or placebo was ingested 30 min before, during and immediately post-exercise and the morning of each recovery day following exercise. Muscle function was determined by peak force during an isometric squat and by jump height during a static jump at pre-exercise (PRE) and 24, 48, 72, and 96 h post-exercise (24, 48, 72, 96 h). Additionally, at these time points each group's serum levels of creatine kinase (CK) and myoglobin (Mb) along with perceived feelings of muscle soreness were determined. None of the C group dependent variables was altered by the recurring testing procedures. Peak force was significantly decreased across all time points for both experimental groups. The L group experienced an attenuated drop in mean peak force across all post-exercise time points compared to the P group. Jump height significantly decreased from PRE for both the L and P group at 24 h and 48 h. CK and Mb was significantly elevated from PRE for both experimental groups at 24 h. Muscle soreness increased across all time points for the both the L and P group, and the L group experienced a significantly higher increase in mean muscle soreness post-exercise. Following exercise-induced muscle damage, high-dose leucine supplementation may help maintain force output during isometric contractions, however, not force output required for complex physical tasks thereby possibly limiting its ergogenic effectiveness.

Authors+Show Affiliations

Neuromuscular Laboratory, Department of Health, Leisure and Exercise Science, Appalachian State University, Boone, NC, USA. kirbytj@appstate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21562819

Citation

Kirby, Tyler J., et al. "Effect of Leucine Supplementation On Indices of Muscle Damage Following Drop Jumps and Resistance Exercise." Amino Acids, vol. 42, no. 5, 2012, pp. 1987-96.
Kirby TJ, Triplett NT, Haines TL, et al. Effect of leucine supplementation on indices of muscle damage following drop jumps and resistance exercise. Amino Acids. 2012;42(5):1987-96.
Kirby, T. J., Triplett, N. T., Haines, T. L., Skinner, J. W., Fairbrother, K. R., & McBride, J. M. (2012). Effect of leucine supplementation on indices of muscle damage following drop jumps and resistance exercise. Amino Acids, 42(5), 1987-96. https://doi.org/10.1007/s00726-011-0928-9
Kirby TJ, et al. Effect of Leucine Supplementation On Indices of Muscle Damage Following Drop Jumps and Resistance Exercise. Amino Acids. 2012;42(5):1987-96. PubMed PMID: 21562819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of leucine supplementation on indices of muscle damage following drop jumps and resistance exercise. AU - Kirby,Tyler J, AU - Triplett,N Travis, AU - Haines,Tracie L, AU - Skinner,Jared W, AU - Fairbrother,Kimberly R, AU - McBride,Jeffrey M, Y1 - 2011/05/12/ PY - 2011/02/07/received PY - 2011/04/28/accepted PY - 2011/5/13/entrez PY - 2011/5/13/pubmed PY - 2012/10/2/medline SP - 1987 EP - 96 JF - Amino acids JO - Amino Acids VL - 42 IS - 5 N2 - The purpose of this study was to determine the effect of leucine supplementation on indices of muscle damage following eccentric-based resistance exercise. In vitro, the amino acid leucine has been shown to reduce proteolysis and stimulate protein synthesis. Twenty-seven untrained males (height 178.6±5.5 cm; body mass 77.7±13.5 kg; age 21.3±1.6 years) were randomly divided into three groups; leucine (L) (n=10), placebo (P) (n=9) and control (C) (n=8). The two experimental groups (L and P) performed 100 depth jumps from 60 cm and six sets of ten repetitions of eccentric-only leg presses. Either leucine (250 mg/kg bm) or placebo was ingested 30 min before, during and immediately post-exercise and the morning of each recovery day following exercise. Muscle function was determined by peak force during an isometric squat and by jump height during a static jump at pre-exercise (PRE) and 24, 48, 72, and 96 h post-exercise (24, 48, 72, 96 h). Additionally, at these time points each group's serum levels of creatine kinase (CK) and myoglobin (Mb) along with perceived feelings of muscle soreness were determined. None of the C group dependent variables was altered by the recurring testing procedures. Peak force was significantly decreased across all time points for both experimental groups. The L group experienced an attenuated drop in mean peak force across all post-exercise time points compared to the P group. Jump height significantly decreased from PRE for both the L and P group at 24 h and 48 h. CK and Mb was significantly elevated from PRE for both experimental groups at 24 h. Muscle soreness increased across all time points for the both the L and P group, and the L group experienced a significantly higher increase in mean muscle soreness post-exercise. Following exercise-induced muscle damage, high-dose leucine supplementation may help maintain force output during isometric contractions, however, not force output required for complex physical tasks thereby possibly limiting its ergogenic effectiveness. SN - 1438-2199 UR - https://wwww.unboundmedicine.com/medline/citation/21562819/Effect_of_leucine_supplementation_on_indices_of_muscle_damage_following_drop_jumps_and_resistance_exercise_ L2 - https://dx.doi.org/10.1007/s00726-011-0928-9 DB - PRIME DP - Unbound Medicine ER -