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[Atropine poisoning by Mandragora autumnalis. A report of 15 cases].
Med Clin (Barc). 1990 Nov 24; 95(18):689-92.MC

Abstract

Anticholinergic syndrome (AS) due to accidental poisoning is exceptional. Mandragora contains a high concentration of atropine, hiosciamine and scopolamine. We have evaluated 15 patients with AS due to poisoning by Mandragora autumnalis, distributed in two family groups. The latency period since the ingestion was 1-4 hours (Means = 2.7 +/- 0.9). The clinical features corresponded to an AS of variable severity. All patients had blurred vision and dryness of mouth, nine (60%) had difficult micturition, nine dizziness, nine headache, eight (53%) vomit, two difficult swallowing and two abdominal pain. There was no correlation between the latency period and the clinical severity. Blushing, areactive mydriasis and tachycardia were found in all, dry skin and mucosae in 14 (93%), hyperactivity/hallucination in 14 and agitation/delirium in nine (60%). One patient developed a florid psychotic episode. Prostigmine (2-6 mg) was administered to 11 patients and physostigmine (0.5-2 mg) to six. The time until a definite response was observed was variable (3-36 hours). The patients treated with physostigmine had a better reversal of the psychoneurological symptoms. Mandragora was identified intermingled with chard [correction of stalwort] (Beta vulgaris) and spinach (Spinacia oleracea) leaves, and atropine and hiosciamine were identified.

Authors+Show Affiliations

Departamento de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

2087109

Citation

Jiménez-Mejías, M E., et al. "[Atropine Poisoning By Mandragora Autumnalis. a Report of 15 Cases]." Medicina Clinica, vol. 95, no. 18, 1990, pp. 689-92.
Jiménez-Mejías ME, Montaño-Díaz M, López Pardo F, et al. [Atropine poisoning by Mandragora autumnalis. A report of 15 cases]. Med Clin (Barc). 1990;95(18):689-92.
Jiménez-Mejías, M. E., Montaño-Díaz, M., López Pardo, F., Campos Jiménez, E., Martín Cordero, M. C., Ayuso González, M. J., & González de la Puente, . (1990). [Atropine poisoning by Mandragora autumnalis. A report of 15 cases]. Medicina Clinica, 95(18), 689-92.
Jiménez-Mejías ME, et al. [Atropine Poisoning By Mandragora Autumnalis. a Report of 15 Cases]. Med Clin (Barc). 1990 Nov 24;95(18):689-92. PubMed PMID: 2087109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Atropine poisoning by Mandragora autumnalis. A report of 15 cases]. AU - Jiménez-Mejías,M E, AU - Montaño-Díaz,M, AU - López Pardo,F, AU - Campos Jiménez,E, AU - Martín Cordero,M C, AU - Ayuso González,M J, AU - González de la Puente,, PY - 1990/11/24/pubmed PY - 1990/11/24/medline PY - 1990/11/24/entrez SP - 689 EP - 92 JF - Medicina clinica JO - Med Clin (Barc) VL - 95 IS - 18 N2 - Anticholinergic syndrome (AS) due to accidental poisoning is exceptional. Mandragora contains a high concentration of atropine, hiosciamine and scopolamine. We have evaluated 15 patients with AS due to poisoning by Mandragora autumnalis, distributed in two family groups. The latency period since the ingestion was 1-4 hours (Means = 2.7 +/- 0.9). The clinical features corresponded to an AS of variable severity. All patients had blurred vision and dryness of mouth, nine (60%) had difficult micturition, nine dizziness, nine headache, eight (53%) vomit, two difficult swallowing and two abdominal pain. There was no correlation between the latency period and the clinical severity. Blushing, areactive mydriasis and tachycardia were found in all, dry skin and mucosae in 14 (93%), hyperactivity/hallucination in 14 and agitation/delirium in nine (60%). One patient developed a florid psychotic episode. Prostigmine (2-6 mg) was administered to 11 patients and physostigmine (0.5-2 mg) to six. The time until a definite response was observed was variable (3-36 hours). The patients treated with physostigmine had a better reversal of the psychoneurological symptoms. Mandragora was identified intermingled with chard [correction of stalwort] (Beta vulgaris) and spinach (Spinacia oleracea) leaves, and atropine and hiosciamine were identified. SN - 0025-7753 UR - https://wwww.unboundmedicine.com/medline/citation/2087109/[Atropine_poisoning_by_Mandragora_autumnalis__A_report_of_15_cases]_ DB - PRIME DP - Unbound Medicine ER -