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Use of physostigmine for hallucinogenic plant poisoning in a teenager: case report and review of the literature.
Am J Ther. 2012 Sep; 19(5):384-8.AJ

Abstract

The objective of this study was to utilize a case report to review the use of physostigmine for jimsonweed intoxication. A 15-year-old girl was found at school hallucinating and incoherent. Upon presentation to the emergency department, she was found to be tachycardic and confused with dilated pupils and dry, flushed, hot skin. She was admitted to our institution. Hallucinations and symptoms resolved after the use of physostigmine. She subsequently admitted to ingesting 'moonflower seeds,' which are derived from Jimsonweed (Datura stramonium). She was discharged when she got well. Jimsonweed is known to contain high concentrations of anticholinergic substances; hence, ingestion can result in the anticholinergic toxidrome. Signs and symptoms include hallucinations, tachycardia, dilated pupils, and disorientation. In our patient, the use of the physostigmine as an antidote resulted in a favorable outcome without any complications. Ingestion of the Datura species can result in severe toxicity. Each plant varies in the concentrations of alkaloid substances. For this reason, it is very important for individuals to become educated on the toxicities and potential risks associated with recreational use of these plants. The use of physostigmine can help in both the diagnosis and management of patients intoxicated with these substances.

Authors+Show Affiliations

Division of Pediatric Emergency Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

20861718

Citation

Glatstein, Miguel Marcelo, et al. "Use of Physostigmine for Hallucinogenic Plant Poisoning in a Teenager: Case Report and Review of the Literature." American Journal of Therapeutics, vol. 19, no. 5, 2012, pp. 384-8.
Glatstein MM, Alabdulrazzaq F, Garcia-Bournissen F, et al. Use of physostigmine for hallucinogenic plant poisoning in a teenager: case report and review of the literature. Am J Ther. 2012;19(5):384-8.
Glatstein, M. M., Alabdulrazzaq, F., Garcia-Bournissen, F., & Scolnik, D. (2012). Use of physostigmine for hallucinogenic plant poisoning in a teenager: case report and review of the literature. American Journal of Therapeutics, 19(5), 384-8. https://doi.org/10.1097/MJT.0b013e3181f0cbb4
Glatstein MM, et al. Use of Physostigmine for Hallucinogenic Plant Poisoning in a Teenager: Case Report and Review of the Literature. Am J Ther. 2012;19(5):384-8. PubMed PMID: 20861718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of physostigmine for hallucinogenic plant poisoning in a teenager: case report and review of the literature. AU - Glatstein,Miguel Marcelo, AU - Alabdulrazzaq,Fatoumah, AU - Garcia-Bournissen,Facundo, AU - Scolnik,Dennis, PY - 2010/9/24/entrez PY - 2010/9/24/pubmed PY - 2013/1/26/medline SP - 384 EP - 8 JF - American journal of therapeutics JO - Am J Ther VL - 19 IS - 5 N2 - The objective of this study was to utilize a case report to review the use of physostigmine for jimsonweed intoxication. A 15-year-old girl was found at school hallucinating and incoherent. Upon presentation to the emergency department, she was found to be tachycardic and confused with dilated pupils and dry, flushed, hot skin. She was admitted to our institution. Hallucinations and symptoms resolved after the use of physostigmine. She subsequently admitted to ingesting 'moonflower seeds,' which are derived from Jimsonweed (Datura stramonium). She was discharged when she got well. Jimsonweed is known to contain high concentrations of anticholinergic substances; hence, ingestion can result in the anticholinergic toxidrome. Signs and symptoms include hallucinations, tachycardia, dilated pupils, and disorientation. In our patient, the use of the physostigmine as an antidote resulted in a favorable outcome without any complications. Ingestion of the Datura species can result in severe toxicity. Each plant varies in the concentrations of alkaloid substances. For this reason, it is very important for individuals to become educated on the toxicities and potential risks associated with recreational use of these plants. The use of physostigmine can help in both the diagnosis and management of patients intoxicated with these substances. SN - 1536-3686 UR - https://wwww.unboundmedicine.com/medline/citation/20861718/Use_of_physostigmine_for_hallucinogenic_plant_poisoning_in_a_teenager:_case_report_and_review_of_the_literature_ DB - PRIME DP - Unbound Medicine ER -