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Acute cyanide poisoning among jewelry and textile industry workers.
Am J Emerg Med. 2011 Jan; 29(1):78-81.AJ

Abstract

Limited work has focused on occupational exposures that may increase the risk of cyanide poisoning by ingestion. A retrospective chart review of all admissions for acute cyanide poisoning by ingestion for the years 1988 to 2008 was conducted in a tertiary university hospital serving the largest population in the country working in jewelry and textile facilities. Of the 9 patients admitted to the hospital during the study period, 8 (7 males, 1 female; age 36 ± 11 years, mean ± SD) attempted suicide by ingestion of potassium cyanide used in their profession as goldsmiths or textile industry workers. Five patients had severe neurologic impairment and severe metabolic acidosis (pH 7.02 ± 0.08, mean ± SD) with high anion gap (23 ± 4 mmol/L, mean ± SD). Of the 5 severely intoxicated patients, 3 received antidote therapy (sodium thiosulfate or hydroxocobalamin) and resumed full consciousness in less than 8 hours. All patients survived without major sequelae. Cyanide intoxication by ingestion in our patients was mainly suicidal and occurred in specific jobs where potassium cyanide is used. Metabolic acidosis with high anion is a good surrogated marker of severe cyanide poisoning. Sodium thiosulfate and hydroxocobalamin are both safe and effective antidotes.

Authors+Show Affiliations

Institute of Pharmacology and Therapeutics, University of Porto, Portugal. coentrao@med.up.ptNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20825788

Citation

Coentrão, Luís, and Daniel Moura. "Acute Cyanide Poisoning Among Jewelry and Textile Industry Workers." The American Journal of Emergency Medicine, vol. 29, no. 1, 2011, pp. 78-81.
Coentrão L, Moura D. Acute cyanide poisoning among jewelry and textile industry workers. Am J Emerg Med. 2011;29(1):78-81.
Coentrão, L., & Moura, D. (2011). Acute cyanide poisoning among jewelry and textile industry workers. The American Journal of Emergency Medicine, 29(1), 78-81. https://doi.org/10.1016/j.ajem.2009.09.014
Coentrão L, Moura D. Acute Cyanide Poisoning Among Jewelry and Textile Industry Workers. Am J Emerg Med. 2011;29(1):78-81. PubMed PMID: 20825788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute cyanide poisoning among jewelry and textile industry workers. AU - Coentrão,Luís, AU - Moura,Daniel, Y1 - 2010/04/02/ PY - 2009/06/03/received PY - 2009/09/14/revised PY - 2009/09/15/accepted PY - 2010/9/10/entrez PY - 2010/9/10/pubmed PY - 2011/1/12/medline SP - 78 EP - 81 JF - The American journal of emergency medicine JO - Am J Emerg Med VL - 29 IS - 1 N2 - Limited work has focused on occupational exposures that may increase the risk of cyanide poisoning by ingestion. A retrospective chart review of all admissions for acute cyanide poisoning by ingestion for the years 1988 to 2008 was conducted in a tertiary university hospital serving the largest population in the country working in jewelry and textile facilities. Of the 9 patients admitted to the hospital during the study period, 8 (7 males, 1 female; age 36 ± 11 years, mean ± SD) attempted suicide by ingestion of potassium cyanide used in their profession as goldsmiths or textile industry workers. Five patients had severe neurologic impairment and severe metabolic acidosis (pH 7.02 ± 0.08, mean ± SD) with high anion gap (23 ± 4 mmol/L, mean ± SD). Of the 5 severely intoxicated patients, 3 received antidote therapy (sodium thiosulfate or hydroxocobalamin) and resumed full consciousness in less than 8 hours. All patients survived without major sequelae. Cyanide intoxication by ingestion in our patients was mainly suicidal and occurred in specific jobs where potassium cyanide is used. Metabolic acidosis with high anion is a good surrogated marker of severe cyanide poisoning. Sodium thiosulfate and hydroxocobalamin are both safe and effective antidotes. SN - 1532-8171 UR - https://wwww.unboundmedicine.com/medline/citation/20825788/Acute_cyanide_poisoning_among_jewelry_and_textile_industry_workers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-6757(09)00473-2 DB - PRIME DP - Unbound Medicine ER -