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Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa.
Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14691-6.PN

Abstract

Gut microbial composition depends on different dietary habits just as health depends on microbial metabolism, but the association of microbiota with different diets in human populations has not yet been shown. In this work, we compared the fecal microbiota of European children (EU) and that of children from a rural African village of Burkina Faso (BF), where the diet, high in fiber content, is similar to that of early human settlements at the time of the birth of agriculture. By using high-throughput 16S rDNA sequencing and biochemical analyses, we found significant differences in gut microbiota between the two groups. BF children showed a significant enrichment in Bacteroidetes and depletion in Firmicutes (P < 0.001), with a unique abundance of bacteria from the genus Prevotella and Xylanibacter, known to contain a set of bacterial genes for cellulose and xylan hydrolysis, completely lacking in the EU children. In addition, we found significantly more short-chain fatty acids (P < 0.001) in BF than in EU children. Also, Enterobacteriaceae (Shigella and Escherichia) were significantly underrepresented in BF than in EU children (P < 0.05). We hypothesize that gut microbiota coevolved with the polysaccharide-rich diet of BF individuals, allowing them to maximize energy intake from fibers while also protecting them from inflammations and noninfectious colonic diseases. This study investigates and compares human intestinal microbiota from children characterized by a modern western diet and a rural diet, indicating the importance of preserving this treasure of microbial diversity from ancient rural communities worldwide.

Authors+Show Affiliations

Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Firenze, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20679230

Citation

De Filippo, Carlotta, et al. "Impact of Diet in Shaping Gut Microbiota Revealed By a Comparative Study in Children From Europe and Rural Africa." Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 33, 2010, pp. 14691-6.
De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A. 2010;107(33):14691-6.
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences of the United States of America, 107(33), 14691-6. https://doi.org/10.1073/pnas.1005963107
De Filippo C, et al. Impact of Diet in Shaping Gut Microbiota Revealed By a Comparative Study in Children From Europe and Rural Africa. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-6. PubMed PMID: 20679230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. AU - De Filippo,Carlotta, AU - Cavalieri,Duccio, AU - Di Paola,Monica, AU - Ramazzotti,Matteo, AU - Poullet,Jean Baptiste, AU - Massart,Sebastien, AU - Collini,Silvia, AU - Pieraccini,Giuseppe, AU - Lionetti,Paolo, Y1 - 2010/08/02/ PY - 2010/8/4/entrez PY - 2010/8/4/pubmed PY - 2010/9/29/medline SP - 14691 EP - 6 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 107 IS - 33 N2 - Gut microbial composition depends on different dietary habits just as health depends on microbial metabolism, but the association of microbiota with different diets in human populations has not yet been shown. In this work, we compared the fecal microbiota of European children (EU) and that of children from a rural African village of Burkina Faso (BF), where the diet, high in fiber content, is similar to that of early human settlements at the time of the birth of agriculture. By using high-throughput 16S rDNA sequencing and biochemical analyses, we found significant differences in gut microbiota between the two groups. BF children showed a significant enrichment in Bacteroidetes and depletion in Firmicutes (P < 0.001), with a unique abundance of bacteria from the genus Prevotella and Xylanibacter, known to contain a set of bacterial genes for cellulose and xylan hydrolysis, completely lacking in the EU children. In addition, we found significantly more short-chain fatty acids (P < 0.001) in BF than in EU children. Also, Enterobacteriaceae (Shigella and Escherichia) were significantly underrepresented in BF than in EU children (P < 0.05). We hypothesize that gut microbiota coevolved with the polysaccharide-rich diet of BF individuals, allowing them to maximize energy intake from fibers while also protecting them from inflammations and noninfectious colonic diseases. This study investigates and compares human intestinal microbiota from children characterized by a modern western diet and a rural diet, indicating the importance of preserving this treasure of microbial diversity from ancient rural communities worldwide. SN - 1091-6490 UR - https://wwww.unboundmedicine.com/medline/citation/20679230/Impact_of_diet_in_shaping_gut_microbiota_revealed_by_a_comparative_study_in_children_from_Europe_and_rural_Africa_ L2 - http://www.pnas.org/lookup/pmidlookup?view=long&amp;pmid=20679230 DB - PRIME DP - Unbound Medicine ER -