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[Gastroprotective properties of mexidol and hypoxen].

Abstract

Experimental damage in the stomach mucosa of test rats was modeled by acetylsalicylic acid (aspirin-induced ulcerogenesis). The number of ulcers and the total area of erosive injury in the mucous membrane were studied. Prophylactic treatment with mexidol and hypoxen in a daily dose of 50 mg/kg reduces the aspirin-induced damage of stomach mucosa. The gastroprotective properties of drugs are probably related to their antioxidant and antihypoxant effects.

Authors

Novikov VE
,
Kriukova NO
,
Novikov AS

Source

MeSH

Animals
Anti-Inflammatory Agents, Non-Steroidal
Antioxidants
Aspirin
Gastric Mucosa
Phenyl Ethers
Picolines
Rats
Stomach Ulcer

Pub Type(s)

Journal Article

Language

rus

PubMed ID

20597364

Citation

Novikov, V E., et al. "[Gastroprotective Properties of Mexidol and Hypoxen]." Eksperimental'naia I Klinicheskaia Farmakologiia, vol. 73, no. 5, 2010, pp. 15-8.
Novikov VE, Kriukova NO, Novikov AS. [Gastroprotective properties of mexidol and hypoxen]. Eksp Klin Farmakol. 2010;73(5):15-8.
Novikov, V. E., Kriukova, N. O., & Novikov, A. S. (2010). [Gastroprotective properties of mexidol and hypoxen]. Eksperimental'naia I Klinicheskaia Farmakologiia, 73(5), pp. 15-8.
Novikov VE, Kriukova NO, Novikov AS. [Gastroprotective Properties of Mexidol and Hypoxen]. Eksp Klin Farmakol. 2010;73(5):15-8. PubMed PMID: 20597364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Gastroprotective properties of mexidol and hypoxen]. AU - Novikov,V E, AU - Kriukova,N O, AU - Novikov,A S, PY - 2010/7/6/entrez PY - 2010/7/6/pubmed PY - 2010/7/21/medline SP - 15 EP - 8 JF - Eksperimental'naia i klinicheskaia farmakologiia JO - Eksp Klin Farmakol VL - 73 IS - 5 N2 - Experimental damage in the stomach mucosa of test rats was modeled by acetylsalicylic acid (aspirin-induced ulcerogenesis). The number of ulcers and the total area of erosive injury in the mucous membrane were studied. Prophylactic treatment with mexidol and hypoxen in a daily dose of 50 mg/kg reduces the aspirin-induced damage of stomach mucosa. The gastroprotective properties of drugs are probably related to their antioxidant and antihypoxant effects. SN - 0869-2092 UR - https://wwww.unboundmedicine.com/medline/citation/20597364/[Gastroprotective_properties_of_mexidol_and_hypoxen] L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -