Tags

Type your tag names separated by a space and hit enter

Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees.
J Agric Food Chem. 2009 Oct 28; 57(20):9801-8.JA

Abstract

Oxidative stress is involved in many neurodegenerative processes leading to age-related cognitive decline. Coffee, a widely consumed beverage, is rich in many bioactive components, including polyphenols with antioxidant potential. In this study, regular and decaffeinated samples of both roasted and green coffee all showed high hydrophilic antioxidant activity in vitro, whereas lipophilic antioxidant activities were on average 30-fold higher in roasted than in green coffee samples. In primary neuronal cell culture, pretreatment with green and roasted coffees (regular and decaffeinated) protected against subsequent H(2)O(2)-induced oxidative stress and improved neuronal cell survival (green coffees increased neuron survival by 78%, compared to 203% by roasted coffees). All coffee extracts inhibited ERK1/2 activation, indicating a potential attenuating effect in stress-induced neuronal cell death. Interestingly, only roasted coffee extracts inhibited JNK activation, evidencing a distinctive neuroprotective benefit. Analysis of coffee phenolic compounds revealed that roasted coffees contained high levels of chlorogenic acid lactones (CGLs); a significant correlation between CGLs and neuroprotective efficacy was observed (R(2) = 0.98). In conclusion, this study showed that roasted coffees are high in lipophilic antioxidants and CGLs, can protect neuronal cells against oxidative stress, and may do so by modulation of the ERK1/2 and JNK signaling pathways.

Authors+Show Affiliations

Kraft Foods Research & Nutrition, 801 Waukegan Road, Glenview, Illinois 60025, USA. yifang.chu@kraft.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19772322

Citation

Chu, Yi-Fang, et al. "Roasted Coffees High in Lipophilic Antioxidants and Chlorogenic Acid Lactones Are More Neuroprotective Than Green Coffees." Journal of Agricultural and Food Chemistry, vol. 57, no. 20, 2009, pp. 9801-8.
Chu YF, Brown PH, Lyle BJ, et al. Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. J Agric Food Chem. 2009;57(20):9801-8.
Chu, Y. F., Brown, P. H., Lyle, B. J., Chen, Y., Black, R. M., Williams, C. E., Lin, Y. C., Hsu, C. W., & Cheng, I. H. (2009). Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. Journal of Agricultural and Food Chemistry, 57(20), 9801-8. https://doi.org/10.1021/jf902095z
Chu YF, et al. Roasted Coffees High in Lipophilic Antioxidants and Chlorogenic Acid Lactones Are More Neuroprotective Than Green Coffees. J Agric Food Chem. 2009 Oct 28;57(20):9801-8. PubMed PMID: 19772322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees. AU - Chu,Yi-Fang, AU - Brown,Peter H, AU - Lyle,Barbara J, AU - Chen,Yumin, AU - Black,Richard M, AU - Williams,Claire E, AU - Lin,Yi-Ching, AU - Hsu,Chih-Wei, AU - Cheng,Irene H, PY - 2009/9/24/entrez PY - 2009/9/24/pubmed PY - 2010/10/5/medline SP - 9801 EP - 8 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 57 IS - 20 N2 - Oxidative stress is involved in many neurodegenerative processes leading to age-related cognitive decline. Coffee, a widely consumed beverage, is rich in many bioactive components, including polyphenols with antioxidant potential. In this study, regular and decaffeinated samples of both roasted and green coffee all showed high hydrophilic antioxidant activity in vitro, whereas lipophilic antioxidant activities were on average 30-fold higher in roasted than in green coffee samples. In primary neuronal cell culture, pretreatment with green and roasted coffees (regular and decaffeinated) protected against subsequent H(2)O(2)-induced oxidative stress and improved neuronal cell survival (green coffees increased neuron survival by 78%, compared to 203% by roasted coffees). All coffee extracts inhibited ERK1/2 activation, indicating a potential attenuating effect in stress-induced neuronal cell death. Interestingly, only roasted coffee extracts inhibited JNK activation, evidencing a distinctive neuroprotective benefit. Analysis of coffee phenolic compounds revealed that roasted coffees contained high levels of chlorogenic acid lactones (CGLs); a significant correlation between CGLs and neuroprotective efficacy was observed (R(2) = 0.98). In conclusion, this study showed that roasted coffees are high in lipophilic antioxidants and CGLs, can protect neuronal cells against oxidative stress, and may do so by modulation of the ERK1/2 and JNK signaling pathways. SN - 1520-5118 UR - https://wwww.unboundmedicine.com/medline/citation/19772322/Roasted_coffees_high_in_lipophilic_antioxidants_and_chlorogenic_acid_lactones_are_more_neuroprotective_than_green_coffees_ L2 - https://dx.doi.org/10.1021/jf902095z DB - PRIME DP - Unbound Medicine ER -