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Analysis of toxic alkaloids in body samples.
Forensic Sci Int. 2009 Mar 10; 185(1-3):1-9.FS

Abstract

Many plants contain toxic alkaloids which may be dangerous to humans. Despite the large number of poisonous plants, cases of fatal plant poisonings are relatively rare. The frequencies of poisonings and the plants involved are often regionally specific. Plant poisonings can be aggregated into three categories: unintended ingestions, intended ingestions, and poisoning due to abuse of plant material. Unintended ingestions often occur in children or from a mix-up of plants and mushrooms in adults. Intended ingestions are common in homicides and suicides. Increasingly common is the abuse of plants for hallucinogenic reasons. Toxicological analysis of such alkaloids may help in diagnosis of poisoning or abuse cases. This review describes the toxic alkaloids aconitine, atropine, coniine, colchicine, cytisine, dimethyltryptamine, harmine, harmaline, ibogaine, kawain, mescaline, scopolamine, and taxine, which are often involved in fatal and non-fatal poisonings. The paper summarizes the symptoms of the intoxications and reviews the methods of detection of their toxic constituents in biological fluids.

Authors+Show Affiliations

Victorian Institute of Forensic Medicine and Monash University, Department of Forensic Medicine, 57-83 Kavanagh Street, Southbank, 3006, Australia. jochenb@vifm.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19147309

Citation

Beyer, Jochen, et al. "Analysis of Toxic Alkaloids in Body Samples." Forensic Science International, vol. 185, no. 1-3, 2009, pp. 1-9.
Beyer J, Drummer OH, Maurer HH. Analysis of toxic alkaloids in body samples. Forensic Sci Int. 2009;185(1-3):1-9.
Beyer, J., Drummer, O. H., & Maurer, H. H. (2009). Analysis of toxic alkaloids in body samples. Forensic Science International, 185(1-3), 1-9. https://doi.org/10.1016/j.forsciint.2008.12.006
Beyer J, Drummer OH, Maurer HH. Analysis of Toxic Alkaloids in Body Samples. Forensic Sci Int. 2009 Mar 10;185(1-3):1-9. PubMed PMID: 19147309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of toxic alkaloids in body samples. AU - Beyer,Jochen, AU - Drummer,Olaf H, AU - Maurer,Hans H, Y1 - 2009/01/14/ PY - 2008/08/06/received PY - 2008/09/25/revised PY - 2008/12/03/accepted PY - 2009/1/17/entrez PY - 2009/1/17/pubmed PY - 2009/6/9/medline SP - 1 EP - 9 JF - Forensic science international JO - Forensic Sci Int VL - 185 IS - 1-3 N2 - Many plants contain toxic alkaloids which may be dangerous to humans. Despite the large number of poisonous plants, cases of fatal plant poisonings are relatively rare. The frequencies of poisonings and the plants involved are often regionally specific. Plant poisonings can be aggregated into three categories: unintended ingestions, intended ingestions, and poisoning due to abuse of plant material. Unintended ingestions often occur in children or from a mix-up of plants and mushrooms in adults. Intended ingestions are common in homicides and suicides. Increasingly common is the abuse of plants for hallucinogenic reasons. Toxicological analysis of such alkaloids may help in diagnosis of poisoning or abuse cases. This review describes the toxic alkaloids aconitine, atropine, coniine, colchicine, cytisine, dimethyltryptamine, harmine, harmaline, ibogaine, kawain, mescaline, scopolamine, and taxine, which are often involved in fatal and non-fatal poisonings. The paper summarizes the symptoms of the intoxications and reviews the methods of detection of their toxic constituents in biological fluids. SN - 1872-6283 UR - https://wwww.unboundmedicine.com/medline/citation/19147309/Analysis_of_toxic_alkaloids_in_body_samples_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(08)00475-1 DB - PRIME DP - Unbound Medicine ER -