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Antifungal activity of the extracts and saponins from Sapindus saponaria L.
An Acad Bras Cienc. 2007 Dec; 79(4):577-83.AA

Abstract

Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis, C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extract was bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extract and one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separation of this fraction afforded two pure triterpene acetylated saponins: 3-O-(4-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl-hederagenin (1) and 3-O-(3,4-di-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabynopyranosyl-hederagenin (2). The structures of the compounds were based on spectral data ((1)H and 13C NMR, HSQC, HMBC and MS), and on with literature. The saponins isolated showed strong activity against C. parapsilosis.

Authors+Show Affiliations

Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringá, Maringá, PR, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18066429

Citation

Tsuzuki, Joyce K., et al. "Antifungal Activity of the Extracts and Saponins From Sapindus Saponaria L." Anais Da Academia Brasileira De Ciencias, vol. 79, no. 4, 2007, pp. 577-83.
Tsuzuki JK, Svidzinski TI, Shinobu CS, et al. Antifungal activity of the extracts and saponins from Sapindus saponaria L. An Acad Bras Cienc. 2007;79(4):577-83.
Tsuzuki, J. K., Svidzinski, T. I., Shinobu, C. S., Silva, L. F., Rodrigues-Filho, E., Cortez, D. A., & Ferreira, I. C. (2007). Antifungal activity of the extracts and saponins from Sapindus saponaria L. Anais Da Academia Brasileira De Ciencias, 79(4), 577-83.
Tsuzuki JK, et al. Antifungal Activity of the Extracts and Saponins From Sapindus Saponaria L. An Acad Bras Cienc. 2007;79(4):577-83. PubMed PMID: 18066429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal activity of the extracts and saponins from Sapindus saponaria L. AU - Tsuzuki,Joyce K, AU - Svidzinski,Terezinha I E, AU - Shinobu,Cristiane S, AU - Silva,Luiz F A, AU - Rodrigues-Filho,Edson, AU - Cortez,Diógenes A G, AU - Ferreira,Izabel C P, PY - 2006/11/23/received PY - 2007/08/27/accepted PY - 2007/12/11/pubmed PY - 2008/4/22/medline PY - 2007/12/11/entrez SP - 577 EP - 83 JF - Anais da Academia Brasileira de Ciencias JO - An. Acad. Bras. Cienc. VL - 79 IS - 4 N2 - Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis, C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extract was bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extract and one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separation of this fraction afforded two pure triterpene acetylated saponins: 3-O-(4-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranosyl-hederagenin (1) and 3-O-(3,4-di-acetyl-beta-D-xylopyranosyl)-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabynopyranosyl-hederagenin (2). The structures of the compounds were based on spectral data ((1)H and 13C NMR, HSQC, HMBC and MS), and on with literature. The saponins isolated showed strong activity against C. parapsilosis. SN - 0001-3765 UR - https://wwww.unboundmedicine.com/medline/citation/18066429/Antifungal_activity_of_the_extracts_and_saponins_from_Sapindus_saponaria_L_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400002&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -