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Lipids behavior and adverse effects for oral antidiabetic agents in patients with Type 2 diabetes treated with sulfonylureas alone based on systematic review.
Yakugaku Zasshi. 2007 Oct; 127(10):1747-56.YZ

Abstract

The secondary and adverse effects when biguanides, alpha-glycosidase inhibitor or thiazolidine derivative was used with sulphonylurea agent (SU) as compared with those with SU alone in Type 2 diabetes patients by using Systematic Review. Two-agent concurrent treatment groups, taken from studies in which subjects were assigned to a group given only a sulfonylurea agent and a group given a sulfonylurea agent with the other glycemic control agent (combination of a sulfonylurea agent and a biguanide agent (I), combination of a sulfonylurea agent and an alpha-glucosidase inhibitor (II), and combination of a sulfonylurea agent and thiazolidinedione (III)), were studied in a randomized controlled trial. The secondary efficacy outcome measures were total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, and change in body weight. The incidence of hypoglycemia, feeling of fullness, diarrhea, liver dysfunction, and edema was investigated as a safety outcome measure, and the clinical significance of concurrent treatment with a sulfonylurea agent in addition to the other glycemic control agent was investigated. With respect to (II), an antidiabetic effect was showed. As for (III), it had the disadvantage of increased body weight. Furthermore, increase of HDL-C levels, in particular, was observed. The improving effect of (III) on serum lipids may be clinically effective for considering the pathologic condition of diabetes, which is often complicated by hyperlipidemia.

Authors+Show Affiliations

Department of Pharmacy, Akita University Hospital, 1-1-1 Hondo Akita, Akita 010-8543, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

17917433

Citation

Mukai, Junichi, et al. "Lipids Behavior and Adverse Effects for Oral Antidiabetic Agents in Patients With Type 2 Diabetes Treated With Sulfonylureas Alone Based On Systematic Review." Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, vol. 127, no. 10, 2007, pp. 1747-56.
Mukai J, Tada H, Watanabe Y, et al. Lipids behavior and adverse effects for oral antidiabetic agents in patients with Type 2 diabetes treated with sulfonylureas alone based on systematic review. Yakugaku Zasshi. 2007;127(10):1747-56.
Mukai, J., Tada, H., Watanabe, Y., Miura, M., Katsuyama, S., Shoji, T., Mohri, K., Mouri, K., Eto, M., & Suzuki, T. (2007). Lipids behavior and adverse effects for oral antidiabetic agents in patients with Type 2 diabetes treated with sulfonylureas alone based on systematic review. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, 127(10), 1747-56.
Mukai J, et al. Lipids Behavior and Adverse Effects for Oral Antidiabetic Agents in Patients With Type 2 Diabetes Treated With Sulfonylureas Alone Based On Systematic Review. Yakugaku Zasshi. 2007;127(10):1747-56. PubMed PMID: 17917433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipids behavior and adverse effects for oral antidiabetic agents in patients with Type 2 diabetes treated with sulfonylureas alone based on systematic review. AU - Mukai,Junichi, AU - Tada,Hitoshi, AU - Watanabe,Yuka, AU - Miura,Masatomo, AU - Katsuyama,Sou, AU - Shoji,Tohru, AU - Mohri,Kiminori, AU - Mouri,Kiminori, AU - Eto,Masaaki, AU - Suzuki,Toshio, PY - 2007/10/6/pubmed PY - 2008/1/8/medline PY - 2007/10/6/entrez SP - 1747 EP - 56 JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan JO - Yakugaku Zasshi VL - 127 IS - 10 N2 - The secondary and adverse effects when biguanides, alpha-glycosidase inhibitor or thiazolidine derivative was used with sulphonylurea agent (SU) as compared with those with SU alone in Type 2 diabetes patients by using Systematic Review. Two-agent concurrent treatment groups, taken from studies in which subjects were assigned to a group given only a sulfonylurea agent and a group given a sulfonylurea agent with the other glycemic control agent (combination of a sulfonylurea agent and a biguanide agent (I), combination of a sulfonylurea agent and an alpha-glucosidase inhibitor (II), and combination of a sulfonylurea agent and thiazolidinedione (III)), were studied in a randomized controlled trial. The secondary efficacy outcome measures were total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, and change in body weight. The incidence of hypoglycemia, feeling of fullness, diarrhea, liver dysfunction, and edema was investigated as a safety outcome measure, and the clinical significance of concurrent treatment with a sulfonylurea agent in addition to the other glycemic control agent was investigated. With respect to (II), an antidiabetic effect was showed. As for (III), it had the disadvantage of increased body weight. Furthermore, increase of HDL-C levels, in particular, was observed. The improving effect of (III) on serum lipids may be clinically effective for considering the pathologic condition of diabetes, which is often complicated by hyperlipidemia. SN - 0031-6903 UR - https://wwww.unboundmedicine.com/medline/citation/17917433/Lipids_behavior_and_adverse_effects_for_oral_antidiabetic_agents_in_patients_with_Type_2_diabetes_treated_with_sulfonylureas_alone_based_on_systematic_review_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/yakushi/127.1747?from=PubMed&lang=en DB - PRIME DP - Unbound Medicine ER -