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Evaluation of hepatoprotective activity of Clerodendrum serratum L.
Indian J Exp Biol. 2007 Jun; 45(6):538-42.IJ

Abstract

The ethanol extract of C. serratum roots and ursolic acid isolated from it were evaluated for hepatoprotective activity against carbon tetrachloride induced toxicity in male Wistar strain rats. The parameters studied were estimation of liver function serum markers such as serum total bilirubin, total protein, alanine transaminase, aspartate transaminase and alkaline phosphatase activities. The ursolic acid showed more significant hepatoprotective activity than crude extract. The histological profile of the liver tissue of the root extract and ursolic acid treated animal showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration as similar to the controls. The results when compared with the standard drug silymarin, revealed that the hepatoprotective activity of the constituent ursolic acid is significant as similar to the standard drug.

Authors+Show Affiliations

Department of Biotechnology, S.R.N.M.N. College of Applied Sciences, Shimoga 577 201, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

17585689

Citation

Vidya, S M., et al. "Evaluation of Hepatoprotective Activity of Clerodendrum Serratum L." Indian Journal of Experimental Biology, vol. 45, no. 6, 2007, pp. 538-42.
Vidya SM, Krishna V, Manjunatha BK, et al. Evaluation of hepatoprotective activity of Clerodendrum serratum L. Indian J Exp Biol. 2007;45(6):538-42.
Vidya, S. M., Krishna, V., Manjunatha, B. K., Mankani, K. L., Ahmed, M., & Singh, S. D. (2007). Evaluation of hepatoprotective activity of Clerodendrum serratum L. Indian Journal of Experimental Biology, 45(6), 538-42.
Vidya SM, et al. Evaluation of Hepatoprotective Activity of Clerodendrum Serratum L. Indian J Exp Biol. 2007;45(6):538-42. PubMed PMID: 17585689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of hepatoprotective activity of Clerodendrum serratum L. AU - Vidya,S M, AU - Krishna,V, AU - Manjunatha,B K, AU - Mankani,K L, AU - Ahmed,Manzoor, AU - Singh,S D Jagadeesh, PY - 2007/6/26/pubmed PY - 2007/8/19/medline PY - 2007/6/26/entrez SP - 538 EP - 42 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 45 IS - 6 N2 - The ethanol extract of C. serratum roots and ursolic acid isolated from it were evaluated for hepatoprotective activity against carbon tetrachloride induced toxicity in male Wistar strain rats. The parameters studied were estimation of liver function serum markers such as serum total bilirubin, total protein, alanine transaminase, aspartate transaminase and alkaline phosphatase activities. The ursolic acid showed more significant hepatoprotective activity than crude extract. The histological profile of the liver tissue of the root extract and ursolic acid treated animal showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration as similar to the controls. The results when compared with the standard drug silymarin, revealed that the hepatoprotective activity of the constituent ursolic acid is significant as similar to the standard drug. SN - 0019-5189 UR - https://wwww.unboundmedicine.com/medline/citation/17585689/Evaluation_of_hepatoprotective_activity_of_Clerodendrum_serratum_L_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -