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Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation.
Am J Emerg Med. 2007 Jun; 25(5):551-8.AJ

Abstract

This chart review was undertaken to assess efficacy and safety of hydroxocobalamin for acute cyanide poisoning. Hospital records of the Fernand Widal and Lariboisière Hospitals were reviewed for intensive care unit admissions with cyanide poisoning for which hydroxocobalamin was used as first-line treatment from 1988 to 2003. Smoke inhalation cases were excluded. Hydroxocobalamin (5-20 g) was administered to 14 consecutive patients beginning a median 2.1 hours after cyanide ingestion or inhalation. Ten patients (71%) survived and were discharged. Of the 11 patients with blood cyanide exceeding the typically lethal threshold of 100 micromol/L, 7 survived. The most common hydroxocobalamin-attributed adverse events were chromaturia and pink skin discoloration. Severe cyanide poisoning of the nature observed in most patients in this study is frequently fatal. That 71% of patients survived after treatment with hydroxocobalamin suggests that hydroxocobalamin as first-line antidotal therapy is effective and safe in acute cyanide poisoning.

Authors+Show Affiliations

University of Texas Health Science Center, San Antonio, TX 78229, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17543660

Citation

Borron, Stephen W., et al. "Hydroxocobalamin for Severe Acute Cyanide Poisoning By Ingestion or Inhalation." The American Journal of Emergency Medicine, vol. 25, no. 5, 2007, pp. 551-8.
Borron SW, Baud FJ, Mégarbane B, et al. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg Med. 2007;25(5):551-8.
Borron, S. W., Baud, F. J., Mégarbane, B., & Bismuth, C. (2007). Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. The American Journal of Emergency Medicine, 25(5), 551-8.
Borron SW, et al. Hydroxocobalamin for Severe Acute Cyanide Poisoning By Ingestion or Inhalation. Am J Emerg Med. 2007;25(5):551-8. PubMed PMID: 17543660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. AU - Borron,Stephen W, AU - Baud,Frédéric J, AU - Mégarbane,Bruno, AU - Bismuth,Chantal, PY - 2006/08/31/received PY - 2006/10/26/accepted PY - 2007/6/5/pubmed PY - 2007/6/28/medline PY - 2007/6/5/entrez SP - 551 EP - 8 JF - The American journal of emergency medicine JO - Am J Emerg Med VL - 25 IS - 5 N2 - This chart review was undertaken to assess efficacy and safety of hydroxocobalamin for acute cyanide poisoning. Hospital records of the Fernand Widal and Lariboisière Hospitals were reviewed for intensive care unit admissions with cyanide poisoning for which hydroxocobalamin was used as first-line treatment from 1988 to 2003. Smoke inhalation cases were excluded. Hydroxocobalamin (5-20 g) was administered to 14 consecutive patients beginning a median 2.1 hours after cyanide ingestion or inhalation. Ten patients (71%) survived and were discharged. Of the 11 patients with blood cyanide exceeding the typically lethal threshold of 100 micromol/L, 7 survived. The most common hydroxocobalamin-attributed adverse events were chromaturia and pink skin discoloration. Severe cyanide poisoning of the nature observed in most patients in this study is frequently fatal. That 71% of patients survived after treatment with hydroxocobalamin suggests that hydroxocobalamin as first-line antidotal therapy is effective and safe in acute cyanide poisoning. SN - 1532-8171 UR - https://wwww.unboundmedicine.com/medline/citation/17543660/Hydroxocobalamin_for_severe_acute_cyanide_poisoning_by_ingestion_or_inhalation_ DB - PRIME DP - Unbound Medicine ER -