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Changes in serum cytokines after repeated bouts of downhill running.
Appl Physiol Nutr Metab. 2007 Apr; 32(2):233-40.AP

Abstract

The purpose of this study was to examine changes in serum cytokines after repeated bouts of aerobically biased eccentric exercise. Six untrained males ran down a -13.5% treadmill grade for 60 min on two occasions (RUN1 and RUN2) at a speed equal to 75% of their VO2 peak on a level grade; runs were spaced 14 d apart. Serum was collected before, after, and every hour for 12 h, and every 24 h for 6 d. Cytokines were assessed using 17 multiplex bead technology (Bio-Rad). Creatine kinase (CK) and delayed-onset muscle soreness (DOMS) were assessed before and 24-120 h after. Results were analyzed using a repeated measures analysis of variance (p <or= 0.05). All comparisons were between RUN1 and RUN2. CK and DOMS were significantly elevated after RUN1 compared with RUN2, indicative of a repeated bout effect. Regarding cytokines, during the initial 12 h period after RUN2, there was a 50% decrease in pro-inflammatory interleukin-6 (IL-6), a 10% decrease in pro-inflammatory macrophage chemotactic protein-1, and a 95% elevation in anti-inflammatory interleukin-10 (IL-10). Regarding 24 h periods, after RUN2 there was an 8% reduction in pro-inflammatory interleukin-8 (IL-8). However, pro-inflammatory macrophage inflammatory factor-1beta (MIF-1beta) was 18% higher during the 12 h after RUN2. The overall cytokine profile suggests a slight reduction in systemic inflammation after RUN2.

Authors+Show Affiliations

Department of Sport and Physical Rehabilitation Sciences, Tshwane University of Technology, Pretoria 0001, South Africa. smithll@tut.ac.zaNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17486164

Citation

Smith, Lucille L., et al. "Changes in Serum Cytokines After Repeated Bouts of Downhill Running." Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, vol. 32, no. 2, 2007, pp. 233-40.
Smith LL, McKune AJ, Semple SJ, et al. Changes in serum cytokines after repeated bouts of downhill running. Appl Physiol Nutr Metab. 2007;32(2):233-40.
Smith, L. L., McKune, A. J., Semple, S. J., Sibanda, E., Steel, H., & Anderson, R. (2007). Changes in serum cytokines after repeated bouts of downhill running. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 32(2), 233-40.
Smith LL, et al. Changes in Serum Cytokines After Repeated Bouts of Downhill Running. Appl Physiol Nutr Metab. 2007;32(2):233-40. PubMed PMID: 17486164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in serum cytokines after repeated bouts of downhill running. AU - Smith,Lucille L, AU - McKune,Andrew J, AU - Semple,Stuart J, AU - Sibanda,Emmanuel, AU - Steel,Helen, AU - Anderson,Ronald, PY - 2007/5/9/pubmed PY - 2007/6/30/medline PY - 2007/5/9/entrez SP - 233 EP - 40 JF - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JO - Appl Physiol Nutr Metab VL - 32 IS - 2 N2 - The purpose of this study was to examine changes in serum cytokines after repeated bouts of aerobically biased eccentric exercise. Six untrained males ran down a -13.5% treadmill grade for 60 min on two occasions (RUN1 and RUN2) at a speed equal to 75% of their VO2 peak on a level grade; runs were spaced 14 d apart. Serum was collected before, after, and every hour for 12 h, and every 24 h for 6 d. Cytokines were assessed using 17 multiplex bead technology (Bio-Rad). Creatine kinase (CK) and delayed-onset muscle soreness (DOMS) were assessed before and 24-120 h after. Results were analyzed using a repeated measures analysis of variance (p <or= 0.05). All comparisons were between RUN1 and RUN2. CK and DOMS were significantly elevated after RUN1 compared with RUN2, indicative of a repeated bout effect. Regarding cytokines, during the initial 12 h period after RUN2, there was a 50% decrease in pro-inflammatory interleukin-6 (IL-6), a 10% decrease in pro-inflammatory macrophage chemotactic protein-1, and a 95% elevation in anti-inflammatory interleukin-10 (IL-10). Regarding 24 h periods, after RUN2 there was an 8% reduction in pro-inflammatory interleukin-8 (IL-8). However, pro-inflammatory macrophage inflammatory factor-1beta (MIF-1beta) was 18% higher during the 12 h after RUN2. The overall cytokine profile suggests a slight reduction in systemic inflammation after RUN2. SN - 1715-5312 UR - https://wwww.unboundmedicine.com/medline/citation/17486164/Changes_in_serum_cytokines_after_repeated_bouts_of_downhill_running_ L2 - https://cdnsciencepub.com/doi/10.1139/h06-106?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -