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Cinacalcet-induced hungry bone syndrome.
Semin Dial. 2007 Jan-Feb; 20(1):83-5.SD

Abstract

Cinacalcet is a type II calcimimetic approved for treatment of secondary hyperparathyroidism in patients with end-stage renal disease. It is generally well tolerated with the most common side effects being nausea and vomiting. Symptomatic hypocalcemia is rare, and persistent hypocalcemia has not been reported to date. We present a case of a 66-year-old woman on chronic outpatient hemodialysis who was initiated on cinacalcet when her intact parathyroid hormone was 1091 pg/mL (normal 15-75 pg/dL). Two weeks later she developed diffuse muscle twitching. The patient required a 72-hour hospitalization and treatment with a continuous intravenous calcium infusion for symptomatic hypocalcemia. The intact parathyroid hormone level at this time was 176 pg/mL. This case is the first report of cinacalcet-induced prolonged and symptomatic hypocalcemia, closely resembling the hungry bone syndrome described in some patients with secondary hyperparathyroidism following surgical parathyroidectomy.

Authors+Show Affiliations

Department of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois 60637, USA.No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17244128

Citation

Lazar, Eric S., and Nicole Stankus. "Cinacalcet-induced Hungry Bone Syndrome." Seminars in Dialysis, vol. 20, no. 1, 2007, pp. 83-5.
Lazar ES, Stankus N. Cinacalcet-induced hungry bone syndrome. Semin Dial. 2007;20(1):83-5.
Lazar, E. S., & Stankus, N. (2007). Cinacalcet-induced hungry bone syndrome. Seminars in Dialysis, 20(1), 83-5.
Lazar ES, Stankus N. Cinacalcet-induced Hungry Bone Syndrome. Semin Dial. 2007 Jan-Feb;20(1):83-5. PubMed PMID: 17244128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cinacalcet-induced hungry bone syndrome. AU - Lazar,Eric S, AU - Stankus,Nicole, PY - 2007/1/25/pubmed PY - 2007/4/4/medline PY - 2007/1/25/entrez SP - 83 EP - 5 JF - Seminars in dialysis JO - Semin Dial VL - 20 IS - 1 N2 - Cinacalcet is a type II calcimimetic approved for treatment of secondary hyperparathyroidism in patients with end-stage renal disease. It is generally well tolerated with the most common side effects being nausea and vomiting. Symptomatic hypocalcemia is rare, and persistent hypocalcemia has not been reported to date. We present a case of a 66-year-old woman on chronic outpatient hemodialysis who was initiated on cinacalcet when her intact parathyroid hormone was 1091 pg/mL (normal 15-75 pg/dL). Two weeks later she developed diffuse muscle twitching. The patient required a 72-hour hospitalization and treatment with a continuous intravenous calcium infusion for symptomatic hypocalcemia. The intact parathyroid hormone level at this time was 176 pg/mL. This case is the first report of cinacalcet-induced prolonged and symptomatic hypocalcemia, closely resembling the hungry bone syndrome described in some patients with secondary hyperparathyroidism following surgical parathyroidectomy. SN - 0894-0959 UR - https://wwww.unboundmedicine.com/medline/citation/17244128/Cinacalcet_induced_hungry_bone_syndrome_ L2 - https://doi.org/10.1111/j.1525-139X.2007.00248.x DB - PRIME DP - Unbound Medicine ER -