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Phosphatidylserine supplementation and recovery following downhill running.
Med Sci Sports Exerc. 2006 Sep; 38(9):1617-25.MS

Abstract

PURPOSE

This study investigated the effects of 750 mg of soybean-derived phosphatidylserine (S-PtdSer), administered daily for 7 d prior to a bout of eccentric exercise and for 2d following exercise, on delayed onset of muscle soreness and markers of muscle damage, inflammation, and oxidative stress that followed prolonged downhill running.

METHODS

Following preliminary testing and a familiarization session, eight recreationally active males repeated an individualized downhill run at -16.5% for 51.0 +/- 1.5 min at 8.7 +/- 0.3 km x h(-1) on four occasions (trials 1-4). Trials 1 and 37 were presupplementation control trials. After trials 1 and 3 the subjects received, in a double-blind and crossover fashion, either S-PtdSer or a glucose polymer placebo. Trials 2 and 3 were separated by a 4-wk washout period. Venous blood, perceived soreness ratings, and feeling states were assessed prior to exercise, after exercise, and at 24 and 48 h after exercise during each trial.

RESULTS

Downhill running led to elevations in perceived soreness (P < 0.05), creatine kinase activities (P < 0.001), myoglobin concentrations (P < 0.001), interleukin-6 (IL-6) concentrations (P < 0.001), and lipid hydroperoxide concentrations (P < 0.01). However, supplementation did not significantly attenuate these responses.

CONCLUSION

These results suggest that supplementation with 750 mg x d(-1) S-PtdSer for 10 d does not afford additional protection against delayed onset of muscle soreness and markers of muscle damage, inflammation, and oxidative stress that follow prolonged downhill running.

Authors+Show Affiliations

University of Wales Swansea, Singleton Park, Swansea, United Kingdom. M.I.C.Kingsley@Swansea.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16960523

Citation

Kingsley, Michael I., et al. "Phosphatidylserine Supplementation and Recovery Following Downhill Running." Medicine and Science in Sports and Exercise, vol. 38, no. 9, 2006, pp. 1617-25.
Kingsley MI, Kilduff LP, McEneny J, et al. Phosphatidylserine supplementation and recovery following downhill running. Med Sci Sports Exerc. 2006;38(9):1617-25.
Kingsley, M. I., Kilduff, L. P., McEneny, J., Dietzig, R. E., & Benton, D. (2006). Phosphatidylserine supplementation and recovery following downhill running. Medicine and Science in Sports and Exercise, 38(9), 1617-25.
Kingsley MI, et al. Phosphatidylserine Supplementation and Recovery Following Downhill Running. Med Sci Sports Exerc. 2006;38(9):1617-25. PubMed PMID: 16960523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphatidylserine supplementation and recovery following downhill running. AU - Kingsley,Michael I, AU - Kilduff,Liam P, AU - McEneny,Jane, AU - Dietzig,Rebecca E, AU - Benton,David, PY - 2006/9/9/pubmed PY - 2006/12/13/medline PY - 2006/9/9/entrez SP - 1617 EP - 25 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 38 IS - 9 N2 - PURPOSE: This study investigated the effects of 750 mg of soybean-derived phosphatidylserine (S-PtdSer), administered daily for 7 d prior to a bout of eccentric exercise and for 2d following exercise, on delayed onset of muscle soreness and markers of muscle damage, inflammation, and oxidative stress that followed prolonged downhill running. METHODS: Following preliminary testing and a familiarization session, eight recreationally active males repeated an individualized downhill run at -16.5% for 51.0 +/- 1.5 min at 8.7 +/- 0.3 km x h(-1) on four occasions (trials 1-4). Trials 1 and 37 were presupplementation control trials. After trials 1 and 3 the subjects received, in a double-blind and crossover fashion, either S-PtdSer or a glucose polymer placebo. Trials 2 and 3 were separated by a 4-wk washout period. Venous blood, perceived soreness ratings, and feeling states were assessed prior to exercise, after exercise, and at 24 and 48 h after exercise during each trial. RESULTS: Downhill running led to elevations in perceived soreness (P < 0.05), creatine kinase activities (P < 0.001), myoglobin concentrations (P < 0.001), interleukin-6 (IL-6) concentrations (P < 0.001), and lipid hydroperoxide concentrations (P < 0.01). However, supplementation did not significantly attenuate these responses. CONCLUSION: These results suggest that supplementation with 750 mg x d(-1) S-PtdSer for 10 d does not afford additional protection against delayed onset of muscle soreness and markers of muscle damage, inflammation, and oxidative stress that follow prolonged downhill running. SN - 0195-9131 UR - https://wwww.unboundmedicine.com/medline/citation/16960523/Phosphatidylserine_supplementation_and_recovery_following_downhill_running_ DB - PRIME DP - Unbound Medicine ER -