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Familial hypotrichosis of the scalp. Autosomal dominant inheritance in four generations.
Acta Derm Venereol. 1991; 71(4):349-51.AD

Abstract

We describe a Danish family of four generations suffering from hypotrichosis of the scalp. Age at onset was 6-17 years and almost total scalp alopecia was reached by the age of 14-21 years. No associated ectodermal defects were present. Nine of 22 persons covering four generations were affected. Growth of the scalp hair slowly decreased and was accompanied by a gradual, diffuse hair loss without regional variation. A scalp biopsy was performed, revealing a non-scarring alopecia with features of androgenetic alopecia. The pedigree was compatible with autosomal dominant inheritance.

Authors+Show Affiliations

Ibsen HH
Department of Dermatology, Odense University Hospital, Denmark.
Clemmensen OJ
No affiliation info available
Brandrup F
No affiliation info available

MeSH

AdultAge FactorsAgedAged, 80 and overBiopsyChildFemaleGenes, DominantHairHumansHypotrichosisMalePedigreeScalp

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1681656

Citation

Ibsen, H H., et al. "Familial Hypotrichosis of the Scalp. Autosomal Dominant Inheritance in Four Generations." Acta Dermato-venereologica, vol. 71, no. 4, 1991, pp. 349-51.
Ibsen HH, Clemmensen OJ, Brandrup F. Familial hypotrichosis of the scalp. Autosomal dominant inheritance in four generations. Acta Derm Venereol. 1991;71(4):349-51.
Ibsen, H. H., Clemmensen, O. J., & Brandrup, F. (1991). Familial hypotrichosis of the scalp. Autosomal dominant inheritance in four generations. Acta Dermato-venereologica, 71(4), 349-51.
Ibsen HH, Clemmensen OJ, Brandrup F. Familial Hypotrichosis of the Scalp. Autosomal Dominant Inheritance in Four Generations. Acta Derm Venereol. 1991;71(4):349-51. PubMed PMID: 1681656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial hypotrichosis of the scalp. Autosomal dominant inheritance in four generations. AU - Ibsen,H H, AU - Clemmensen,O J, AU - Brandrup,F, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 349 EP - 51 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 71 IS - 4 N2 - We describe a Danish family of four generations suffering from hypotrichosis of the scalp. Age at onset was 6-17 years and almost total scalp alopecia was reached by the age of 14-21 years. No associated ectodermal defects were present. Nine of 22 persons covering four generations were affected. Growth of the scalp hair slowly decreased and was accompanied by a gradual, diffuse hair loss without regional variation. A scalp biopsy was performed, revealing a non-scarring alopecia with features of androgenetic alopecia. The pedigree was compatible with autosomal dominant inheritance. SN - 0001-5555 UR - https://wwww.unboundmedicine.com/medline/citation/1681656/Familial_hypotrichosis_of_the_scalp__Autosomal_dominant_inheritance_in_four_generations_ DB - PRIME DP - Unbound Medicine ER -