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An alternative non-invasive treatment for Peyronie's disease.
Int Braz J Urol. 2004 May-Jun; 30(3):199-204; discussion 204.IB

Abstract

OBJECTIVE

Surgical correction of the deformity and plaque caused by Peyronie's disease has some important disadvantages and extracorporeal shockwave therapy (ESWT) emerged as a new promising therapy. We evaluated prospectively the efficacy and safety of the association of high dose vitamin E and ESWT as a non-invasive treatment for the disease.

MATERIALS AND METHODS

Twenty-five patients 42 to 68 years old (mean = 54) presenting penile deviation and sexual distress caused by Peyronie's disease were treated in a non-invasive manner. The time of penile deviation ranged from 16 to 52 months (mean = 30). All patients had previous unsuccessful treatment for Peyronie's disease. The angulation's deformity of the penis was assessed by photography at home. The patients received vitamin E (l.200 mg daily) during 3 months and underwent 3 to 6 sessions (mean = 3) of ESWT (3,000 to 4,000 shockwaves) at a power level of l to 2 at 1-week intervals.

RESULTS

From 25 patients treated, 16 (64%) reported an improvement in penile angulation, with a mean reduction of 21 degrees (10 to 40). Eight patients reported improvement in their spontaneous erections. Overall, the patients presented only minimal bruising at the site of treatment and skin hematoma. Four patients presented urethral bleeding. The mean angulation after treatment in the control group was 48.67 degrees (30 - 70) and in the study group was 24.42 degrees (0 - 70), statistically significant.

CONCLUSION

Considering the common complications and the unsatisfactory outcome of the surgical correction for Peyronie's disease, the association of high dose vitamin E and ESWT represents a good option for a non-invasive, effective and safe treatment of the penile deformity.

Authors+Show Affiliations

Division of Urology, Paulista School of Medicine, Federal University of São Paulo, UNIFESP, São Paulo, SP, Brazil. joaquimclaro@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15689246

Citation

Claro, Joaquim A., et al. "An Alternative Non-invasive Treatment for Peyronie's Disease." International Braz J Urol : Official Journal of the Brazilian Society of Urology, vol. 30, no. 3, 2004, pp. 199-204; discussion 204.
Claro JA, Passerotti CC, Figueiredo Neto AC, et al. An alternative non-invasive treatment for Peyronie's disease. Int Braz J Urol. 2004;30(3):199-204; discussion 204.
Claro, J. A., Passerotti, C. C., Figueiredo Neto, A. C., Nardozza, A., Ortiz, V., & Srougi, M. (2004). An alternative non-invasive treatment for Peyronie's disease. International Braz J Urol : Official Journal of the Brazilian Society of Urology, 30(3), 199-204; discussion 204.
Claro JA, et al. An Alternative Non-invasive Treatment for Peyronie's Disease. Int Braz J Urol. 2004 May-Jun;30(3):199-204; discussion 204. PubMed PMID: 15689246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An alternative non-invasive treatment for Peyronie's disease. AU - Claro,Joaquim A, AU - Passerotti,Carlo C, AU - Figueiredo Neto,Antonio C, AU - Nardozza,Archimedes,Jr AU - Ortiz,Valdemar, AU - Srougi,Miguel, PY - 2004/04/30/received PY - 2004/05/20/accepted PY - 2005/2/4/pubmed PY - 2005/3/2/medline PY - 2005/2/4/entrez SP - 199-204; discussion 204 JF - International braz j urol : official journal of the Brazilian Society of Urology JO - Int Braz J Urol VL - 30 IS - 3 N2 - OBJECTIVE: Surgical correction of the deformity and plaque caused by Peyronie's disease has some important disadvantages and extracorporeal shockwave therapy (ESWT) emerged as a new promising therapy. We evaluated prospectively the efficacy and safety of the association of high dose vitamin E and ESWT as a non-invasive treatment for the disease. MATERIALS AND METHODS: Twenty-five patients 42 to 68 years old (mean = 54) presenting penile deviation and sexual distress caused by Peyronie's disease were treated in a non-invasive manner. The time of penile deviation ranged from 16 to 52 months (mean = 30). All patients had previous unsuccessful treatment for Peyronie's disease. The angulation's deformity of the penis was assessed by photography at home. The patients received vitamin E (l.200 mg daily) during 3 months and underwent 3 to 6 sessions (mean = 3) of ESWT (3,000 to 4,000 shockwaves) at a power level of l to 2 at 1-week intervals. RESULTS: From 25 patients treated, 16 (64%) reported an improvement in penile angulation, with a mean reduction of 21 degrees (10 to 40). Eight patients reported improvement in their spontaneous erections. Overall, the patients presented only minimal bruising at the site of treatment and skin hematoma. Four patients presented urethral bleeding. The mean angulation after treatment in the control group was 48.67 degrees (30 - 70) and in the study group was 24.42 degrees (0 - 70), statistically significant. CONCLUSION: Considering the common complications and the unsatisfactory outcome of the surgical correction for Peyronie's disease, the association of high dose vitamin E and ESWT represents a good option for a non-invasive, effective and safe treatment of the penile deformity. SN - 1677-5538 UR - https://wwww.unboundmedicine.com/medline/citation/15689246/An_alternative_non_invasive_treatment_for_Peyronie's_disease_ DB - PRIME DP - Unbound Medicine ER -