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Metabolic response to prolonged cycling with (13)C-glucose ingestion following downhill running.
Eur J Appl Physiol. 2005 Mar; 93(5-6):598-605.EJ

Abstract

The purpose of this study was to describe the effect of muscle damage and delayed-onset muscle soreness (DOMS) on the metabolic response during a subsequent period of prolonged concentric exercise (120 min, approximately 61% V(.)O(2max), on a cycle ergometer), with ingestion of 3 g of (13)C-glucose/kg body mass. We hypothesized that the oxidation of plasma and exogenous glucose would be reduced, while the oxidation of glucose arising from muscle glycogen would be increased. Six male subjects were studied during exercise in a control situation and 2 days following downhill running, at a time when plasma creatine kinase (CK) activity was increased, and DOMS was present. Carbohydrate and lipid oxidation were computed from indirect respiratory calorimetry corrected for protein oxidation, while the oxidation of plasma glucose and muscle glycogen were computed from V(.)(13)CO(2) and the ratio of (13)C/(12)C in the plasma glucose. All data were presented as the mean and the standard error of the mean. The oxidation of protein (approximately 6% energy yield, in the control and the experimental trial), lipid (approximately 15 and approximately 18%), and carbohydrate (approximately 79 and approximately 76%), as well as that of plasma glucose (approximately 41 and approximately 46%), glucose from the liver (approximately 12 and approximately 14%), and glucose from muscle glycogen (approximately 38 and approximately 31%) were not significantly different between the control and experimental (DOMS) trials. The response of the plasma glucose, insulin, lactate, and free fatty acid concentrations was not modified by the previous eccentric exercise. These results indicate that the metabolic response to prolonged concentric exercise is not modified by muscle damage and DOMS resulting from a bout of eccentric exercise performed 2 days before.

Authors+Show Affiliations

Département de Kinésiologie, Université de Montréal, , Montréal, Québec, H3C 3J7, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15578208

Citation

Racette, Ronald, et al. "Metabolic Response to Prolonged Cycling With (13)C-glucose Ingestion Following Downhill Running." European Journal of Applied Physiology, vol. 93, no. 5-6, 2005, pp. 598-605.
Racette R, Péronnet F, Massicotte D, et al. Metabolic response to prolonged cycling with (13)C-glucose ingestion following downhill running. Eur J Appl Physiol. 2005;93(5-6):598-605.
Racette, R., Péronnet, F., Massicotte, D., & Lavoie, C. (2005). Metabolic response to prolonged cycling with (13)C-glucose ingestion following downhill running. European Journal of Applied Physiology, 93(5-6), 598-605.
Racette R, et al. Metabolic Response to Prolonged Cycling With (13)C-glucose Ingestion Following Downhill Running. Eur J Appl Physiol. 2005;93(5-6):598-605. PubMed PMID: 15578208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic response to prolonged cycling with (13)C-glucose ingestion following downhill running. AU - Racette,Ronald, AU - Péronnet,François, AU - Massicotte,Denis, AU - Lavoie,Carole, Y1 - 2004/12/01/ PY - 2004/09/15/accepted PY - 2004/12/4/pubmed PY - 2005/9/15/medline PY - 2004/12/4/entrez SP - 598 EP - 605 JF - European journal of applied physiology JO - Eur J Appl Physiol VL - 93 IS - 5-6 N2 - The purpose of this study was to describe the effect of muscle damage and delayed-onset muscle soreness (DOMS) on the metabolic response during a subsequent period of prolonged concentric exercise (120 min, approximately 61% V(.)O(2max), on a cycle ergometer), with ingestion of 3 g of (13)C-glucose/kg body mass. We hypothesized that the oxidation of plasma and exogenous glucose would be reduced, while the oxidation of glucose arising from muscle glycogen would be increased. Six male subjects were studied during exercise in a control situation and 2 days following downhill running, at a time when plasma creatine kinase (CK) activity was increased, and DOMS was present. Carbohydrate and lipid oxidation were computed from indirect respiratory calorimetry corrected for protein oxidation, while the oxidation of plasma glucose and muscle glycogen were computed from V(.)(13)CO(2) and the ratio of (13)C/(12)C in the plasma glucose. All data were presented as the mean and the standard error of the mean. The oxidation of protein (approximately 6% energy yield, in the control and the experimental trial), lipid (approximately 15 and approximately 18%), and carbohydrate (approximately 79 and approximately 76%), as well as that of plasma glucose (approximately 41 and approximately 46%), glucose from the liver (approximately 12 and approximately 14%), and glucose from muscle glycogen (approximately 38 and approximately 31%) were not significantly different between the control and experimental (DOMS) trials. The response of the plasma glucose, insulin, lactate, and free fatty acid concentrations was not modified by the previous eccentric exercise. These results indicate that the metabolic response to prolonged concentric exercise is not modified by muscle damage and DOMS resulting from a bout of eccentric exercise performed 2 days before. SN - 1439-6319 UR - https://wwww.unboundmedicine.com/medline/citation/15578208/Metabolic_response_to_prolonged_cycling_with__13_C_glucose_ingestion_following_downhill_running_ DB - PRIME DP - Unbound Medicine ER -