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A 71-year-old man with spindle-cell neoplasm of unknown origin: a difficult-to-diagnose clear-cell sarcoma.
Dermatol Online J. 2004 Jul 15; 10(1):8.DO

Abstract

A patient initially presented in 1988 with a solitary axillary mass, diagnosed as a high-grade neuroendocrine spindle-cell neoplasm; there was no history of a primary cutaneous malignancy. After subsequent development of a pulmonary nodule in 2001 (14-years post initial diagnosis), the case was reviewed and the possibility of metastatic melanoma was raised. The histopathologic and immunohistochemical profile of this melanocytic neoplasm was diagnostic of clear cell sarcoma (CCS) of tendons and aponeuroses, although the differential diagnosis included malignant melanoma, follicular dendritic and interdigitating cell tumors, malignant peripheral nerve sheath tumor, and a category of so-called PEComas. It is the role of pathologists, particularly dermatopathologists, to distinguish CCS from malignant melanoma, and to alert the clinician, because proper diagnosis ultimately influences treatment. We discuss the immunophenotype, differential diagnosis, and molecular signatures of these neoplasms, and review the pertinent literature on these entities.

Authors+Show Affiliations

University of Pittsburgh School of Medicine, USA.No affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

15347490

Citation

Spencer, Lori, and Drazen Jukic. "A 71-year-old Man With Spindle-cell Neoplasm of Unknown Origin: a Difficult-to-diagnose Clear-cell Sarcoma." Dermatology Online Journal, vol. 10, no. 1, 2004, p. 8.
Spencer L, Jukic D. A 71-year-old man with spindle-cell neoplasm of unknown origin: a difficult-to-diagnose clear-cell sarcoma. Dermatol Online J. 2004;10(1):8.
Spencer, L., & Jukic, D. (2004). A 71-year-old man with spindle-cell neoplasm of unknown origin: a difficult-to-diagnose clear-cell sarcoma. Dermatology Online Journal, 10(1), 8.
Spencer L, Jukic D. A 71-year-old Man With Spindle-cell Neoplasm of Unknown Origin: a Difficult-to-diagnose Clear-cell Sarcoma. Dermatol Online J. 2004 Jul 15;10(1):8. PubMed PMID: 15347490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A 71-year-old man with spindle-cell neoplasm of unknown origin: a difficult-to-diagnose clear-cell sarcoma. AU - Spencer,Lori, AU - Jukic,Drazen, Y1 - 2004/07/15/ PY - 2004/9/7/pubmed PY - 2005/6/18/medline PY - 2004/9/7/entrez SP - 8 EP - 8 JF - Dermatology online journal JO - Dermatol Online J VL - 10 IS - 1 N2 - A patient initially presented in 1988 with a solitary axillary mass, diagnosed as a high-grade neuroendocrine spindle-cell neoplasm; there was no history of a primary cutaneous malignancy. After subsequent development of a pulmonary nodule in 2001 (14-years post initial diagnosis), the case was reviewed and the possibility of metastatic melanoma was raised. The histopathologic and immunohistochemical profile of this melanocytic neoplasm was diagnostic of clear cell sarcoma (CCS) of tendons and aponeuroses, although the differential diagnosis included malignant melanoma, follicular dendritic and interdigitating cell tumors, malignant peripheral nerve sheath tumor, and a category of so-called PEComas. It is the role of pathologists, particularly dermatopathologists, to distinguish CCS from malignant melanoma, and to alert the clinician, because proper diagnosis ultimately influences treatment. We discuss the immunophenotype, differential diagnosis, and molecular signatures of these neoplasms, and review the pertinent literature on these entities. SN - 1087-2108 UR - https://wwww.unboundmedicine.com/medline/citation/15347490/A_71_year_old_man_with_spindle_cell_neoplasm_of_unknown_origin:_a_difficult_to_diagnose_clear_cell_sarcoma_ L2 - http://dermatology.cdlib.org/101/case_reports/spindle/spencer.html DB - PRIME DP - Unbound Medicine ER -