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Further studies on the anticancer activity of citrus limonoids.
J Agric Food Chem. 2004 Jul 28; 52(15):4908-12.JA

Abstract

Research in this laboratory has shown that some citrus limonoids can inhibit the development of 7,12-dimethylbenz[a]anthracene-induced oral tumors. The data from these studies have suggested that certain rings in the limonoid nucleus may be critical to antineoplastic activity. Using the hamster cheek pouch model, three new limonoids (ichangensin, deoxylimonin, and obacunone) have now been tested for cancer chemopreventive activity. In the first experiment, it was found that the treatments with ichangensin had no effect on tumor number or burden. In the second experiment, obacunone reduced tumor number and burden by 25 and 40%, respectively, whereas deoxylimonin reduced tumor number and burden by 30 and 50%, respectively. The results with deoxylimonin were significant, p < 0.05. Overall, the data indicated that changes in the A ring of the limonoid nucleus can lead to a loss of anticancer activity, whereas changes in the D ring can be tolerated without any apparent loss of biological activity.

Authors+Show Affiliations

Department of Biomedical Sciences, Baylor College of Dentistry, Texas A&M University System Health Science Center, 3302 Gaston Avenue, Dallas, Texas 75246, USA. emiller@bcd.tamhsc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15264934

Citation

Miller, Edward G., et al. "Further Studies On the Anticancer Activity of Citrus Limonoids." Journal of Agricultural and Food Chemistry, vol. 52, no. 15, 2004, pp. 4908-12.
Miller EG, Porter JL, Binnie WH, et al. Further studies on the anticancer activity of citrus limonoids. J Agric Food Chem. 2004;52(15):4908-12.
Miller, E. G., Porter, J. L., Binnie, W. H., Guo, I. Y., & Hasegawa, S. (2004). Further studies on the anticancer activity of citrus limonoids. Journal of Agricultural and Food Chemistry, 52(15), 4908-12.
Miller EG, et al. Further Studies On the Anticancer Activity of Citrus Limonoids. J Agric Food Chem. 2004 Jul 28;52(15):4908-12. PubMed PMID: 15264934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further studies on the anticancer activity of citrus limonoids. AU - Miller,Edward G, AU - Porter,Jo Lynn, AU - Binnie,William H, AU - Guo,Ingrid Y, AU - Hasegawa,Shin, PY - 2004/7/22/pubmed PY - 2004/9/15/medline PY - 2004/7/22/entrez SP - 4908 EP - 12 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 52 IS - 15 N2 - Research in this laboratory has shown that some citrus limonoids can inhibit the development of 7,12-dimethylbenz[a]anthracene-induced oral tumors. The data from these studies have suggested that certain rings in the limonoid nucleus may be critical to antineoplastic activity. Using the hamster cheek pouch model, three new limonoids (ichangensin, deoxylimonin, and obacunone) have now been tested for cancer chemopreventive activity. In the first experiment, it was found that the treatments with ichangensin had no effect on tumor number or burden. In the second experiment, obacunone reduced tumor number and burden by 25 and 40%, respectively, whereas deoxylimonin reduced tumor number and burden by 30 and 50%, respectively. The results with deoxylimonin were significant, p < 0.05. Overall, the data indicated that changes in the A ring of the limonoid nucleus can lead to a loss of anticancer activity, whereas changes in the D ring can be tolerated without any apparent loss of biological activity. SN - 0021-8561 UR - https://wwww.unboundmedicine.com/medline/citation/15264934/Further_studies_on_the_anticancer_activity_of_citrus_limonoids_ L2 - https://dx.doi.org/10.1021/jf049698g DB - PRIME DP - Unbound Medicine ER -