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An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae.
J Invest Dermatol. 2004 Mar; 122(3):652-7.JI

Abstract

Pseudofolliculitis barbae (PFB) is a common hair disorder characterized by a pustular foreign body inflammatory reaction that is induced by ingrown hairs of the facial and submental (barbea) regions after regular shaving. It occurs predominantly in black males, while it is rather rare and usually far less severe in Caucasian males. Black individuals have a higher propensity of developing PFB due to their genetic predisposition for curly hair which inherently possesses a much higher risk of growing back into the skin than straight or wavy hair. The PFB process is, however, not gender dependent nor restricted to the face, but can occur in any skin region once regular shaving, plucking, or other traumatic means of hair removal are instituted. Through a family study and a large-scale investigation of randomly sampled PFB-affected and -unaffected individuals, this study demonstrates that an unusual single-nucleotide polymorphism, which gives rise to a disruptive Ala12Thr substitution in the 1A alpha-helical segment of the companion layer-specific keratin K6hf of the hair follicle, is partially responsible for the phenotypic expression and represents an additional genetic risk factor for PFB.

Authors+Show Affiliations

Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15086549

Citation

Winter, Hermelita, et al. "An Unusual Ala12Thr Polymorphism in the 1A Alpha-helical Segment of the Companion Layer-specific Keratin K6hf: Evidence for a Risk Factor in the Etiology of the Common Hair Disorder Pseudofolliculitis Barbae." The Journal of Investigative Dermatology, vol. 122, no. 3, 2004, pp. 652-7.
Winter H, Schissel D, Parry DA, et al. An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. J Invest Dermatol. 2004;122(3):652-7.
Winter, H., Schissel, D., Parry, D. A., Smith, T. A., Liovic, M., Birgitte Lane, E., Edler, L., Langbein, L., Jave-Suarez, L. F., Rogers, M. A., Wilde, J., Peters, G., & Schweizer, J. (2004). An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. The Journal of Investigative Dermatology, 122(3), 652-7.
Winter H, et al. An Unusual Ala12Thr Polymorphism in the 1A Alpha-helical Segment of the Companion Layer-specific Keratin K6hf: Evidence for a Risk Factor in the Etiology of the Common Hair Disorder Pseudofolliculitis Barbae. J Invest Dermatol. 2004;122(3):652-7. PubMed PMID: 15086549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. AU - Winter,Hermelita, AU - Schissel,Daniel, AU - Parry,David A D, AU - Smith,Thomasin A, AU - Liovic,Mirjana, AU - Birgitte Lane,E, AU - Edler,Lutz, AU - Langbein,Lutz, AU - Jave-Suarez,Luis F, AU - Rogers,Michael A, AU - Wilde,Joseph, AU - Peters,Gerald, AU - Schweizer,Jürgen, PY - 2004/4/17/pubmed PY - 2004/5/27/medline PY - 2004/4/17/entrez SP - 652 EP - 7 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 122 IS - 3 N2 - Pseudofolliculitis barbae (PFB) is a common hair disorder characterized by a pustular foreign body inflammatory reaction that is induced by ingrown hairs of the facial and submental (barbea) regions after regular shaving. It occurs predominantly in black males, while it is rather rare and usually far less severe in Caucasian males. Black individuals have a higher propensity of developing PFB due to their genetic predisposition for curly hair which inherently possesses a much higher risk of growing back into the skin than straight or wavy hair. The PFB process is, however, not gender dependent nor restricted to the face, but can occur in any skin region once regular shaving, plucking, or other traumatic means of hair removal are instituted. Through a family study and a large-scale investigation of randomly sampled PFB-affected and -unaffected individuals, this study demonstrates that an unusual single-nucleotide polymorphism, which gives rise to a disruptive Ala12Thr substitution in the 1A alpha-helical segment of the companion layer-specific keratin K6hf of the hair follicle, is partially responsible for the phenotypic expression and represents an additional genetic risk factor for PFB. SN - 0022-202X UR - https://wwww.unboundmedicine.com/medline/citation/15086549/An_unusual_Ala12Thr_polymorphism_in_the_1A_alpha_helical_segment_of_the_companion_layer_specific_keratin_K6hf:_evidence_for_a_risk_factor_in_the_etiology_of_the_common_hair_disorder_pseudofolliculitis_barbae_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-202X(15)30693-X DB - PRIME DP - Unbound Medicine ER -