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Hypotrichosis and nail dysplasia: a novel hidrotic ectodermal dysplasia.
Australas J Dermatol. 2004 May; 45(2):103-5.AJ

Abstract

We report a unique isolated hair and nail ectodermal dysplasia in a 3-year-old girl. Clinical examination revealed short, sparse scalp hair, absent eyebrows, short eyelashes and nail dystrophy in all digits. Nail changes included shortened nail plate with distal onycholysis and loss of the cuticle. Sweating and teeth were normal. Development was normal. Scanning electron microscopy of the hair only demonstrated trichorrhexis nodosa. There was no pili torti. Vertically sectioned scalp biopsy revealed hypoplastic hair follicles and a horizontally sectioned biopsy showed a decrease in the overall number of hair follicles present. Treatment with topical minoxidil 5% 1 mL twice each day massaged into the scalp led to only minimal improvement and was discontinued after 12 months.

Authors+Show Affiliations

Harrison S
Department of Medicine (Dermatology), St Vincent's Hospital, Fitzroy, Melbourne, Victoria 5065, Australia.
Sinclair R
No affiliation info available

MeSH

Child, PreschoolDermatologic AgentsEctodermal DysplasiaFemaleFollow-Up StudiesHairHair FollicleHumansHypotrichosisMicroscopy, Electron, ScanningMinoxidilNails, Malformed

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15068456

Citation

Harrison, Shannon, and Rodney Sinclair. "Hypotrichosis and Nail Dysplasia: a Novel Hidrotic Ectodermal Dysplasia." The Australasian Journal of Dermatology, vol. 45, no. 2, 2004, pp. 103-5.
Harrison S, Sinclair R. Hypotrichosis and nail dysplasia: a novel hidrotic ectodermal dysplasia. Australas J Dermatol. 2004;45(2):103-5.
Harrison, S., & Sinclair, R. (2004). Hypotrichosis and nail dysplasia: a novel hidrotic ectodermal dysplasia. The Australasian Journal of Dermatology, 45(2), 103-5.
Harrison S, Sinclair R. Hypotrichosis and Nail Dysplasia: a Novel Hidrotic Ectodermal Dysplasia. Australas J Dermatol. 2004;45(2):103-5. PubMed PMID: 15068456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypotrichosis and nail dysplasia: a novel hidrotic ectodermal dysplasia. AU - Harrison,Shannon, AU - Sinclair,Rodney, PY - 2004/4/8/pubmed PY - 2004/6/18/medline PY - 2004/4/8/entrez SP - 103 EP - 5 JF - The Australasian journal of dermatology JO - Australas J Dermatol VL - 45 IS - 2 N2 - We report a unique isolated hair and nail ectodermal dysplasia in a 3-year-old girl. Clinical examination revealed short, sparse scalp hair, absent eyebrows, short eyelashes and nail dystrophy in all digits. Nail changes included shortened nail plate with distal onycholysis and loss of the cuticle. Sweating and teeth were normal. Development was normal. Scanning electron microscopy of the hair only demonstrated trichorrhexis nodosa. There was no pili torti. Vertically sectioned scalp biopsy revealed hypoplastic hair follicles and a horizontally sectioned biopsy showed a decrease in the overall number of hair follicles present. Treatment with topical minoxidil 5% 1 mL twice each day massaged into the scalp led to only minimal improvement and was discontinued after 12 months. SN - 0004-8380 UR - https://wwww.unboundmedicine.com/medline/citation/15068456/Hypotrichosis_and_nail_dysplasia:_a_novel_hidrotic_ectodermal_dysplasia_ DB - PRIME DP - Unbound Medicine ER -