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A prospective, randomized study using transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease.
J Urol. 2004 Apr; 171(4):1605-8.JU

Abstract

PURPOSE

Uncontrolled studies with intraplaque electromotive administration of verapamil and dexamethasone have demonstrated objective improvements in Peyronie's disease. We performed a prospective controlled study to assess the efficacy of intraplaque electromotive verapamil/dexamethasone vs electromotive lidocaine.

MATERIALS AND METHODS

Patients with Peyronie's disease were randomized into a study group (47 patients) and a control group (49 patients). For each treatment session an electrode receptacle was sited over the plaque and filled with either 5 mg verapamil and 8 mg dexamethasone (study group) or 2% lidocaine (control group), and a 2.4 mA electric current was applied for 20 minutes. All patients were scheduled for 4 sessions per week for 6 weeks. Assessment before and after treatment included measurements of plaque volume and penile curvature, and pain on erection (from questionnaire).

RESULTS

A total of 37 patients in the study group and 36 in the control group completed treatment courses. In the study group there were significant decreases in median plaque volume from 824 to 348 mm, and in penile curvature from 43 to 21 degrees. In the control group median volume and curvature were unchanged. The difference in results after treatment between the 2 groups was also significant. Significant pain relief occurred in both groups, transient in the control group and permanent in the study group. All patients experienced temporary erythema at the electrode site. There were no other side effects.

CONCLUSIONS

Intraplaque electromotive verapamil and dexamethasone induce substantial objective improvement in Peyronie's disease compared to electromotive lidocaine administration.

Authors+Show Affiliations

Department of Urology, Tor Vergata University, Rome, Italy. sdistas@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15017231

Citation

Di Stasi, Savino M., et al. "A Prospective, Randomized Study Using Transdermal Electromotive Administration of Verapamil and Dexamethasone for Peyronie's Disease." The Journal of Urology, vol. 171, no. 4, 2004, pp. 1605-8.
Di Stasi SM, Giannantoni A, Stephen RL, et al. A prospective, randomized study using transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease. J Urol. 2004;171(4):1605-8.
Di Stasi, S. M., Giannantoni, A., Stephen, R. L., Capelli, G., Giurioli, A., Jannini, E. A., & Vespasiani, G. (2004). A prospective, randomized study using transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease. The Journal of Urology, 171(4), 1605-8.
Di Stasi SM, et al. A Prospective, Randomized Study Using Transdermal Electromotive Administration of Verapamil and Dexamethasone for Peyronie's Disease. J Urol. 2004;171(4):1605-8. PubMed PMID: 15017231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective, randomized study using transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease. AU - Di Stasi,Savino M, AU - Giannantoni,Antonella, AU - Stephen,Robert L, AU - Capelli,Giovanni, AU - Giurioli,Arcangelo, AU - Jannini,Emmanuele A, AU - Vespasiani,Giuseppe, PY - 2004/3/17/pubmed PY - 2004/5/7/medline PY - 2004/3/17/entrez SP - 1605 EP - 8 JF - The Journal of urology JO - J Urol VL - 171 IS - 4 N2 - PURPOSE: Uncontrolled studies with intraplaque electromotive administration of verapamil and dexamethasone have demonstrated objective improvements in Peyronie's disease. We performed a prospective controlled study to assess the efficacy of intraplaque electromotive verapamil/dexamethasone vs electromotive lidocaine. MATERIALS AND METHODS: Patients with Peyronie's disease were randomized into a study group (47 patients) and a control group (49 patients). For each treatment session an electrode receptacle was sited over the plaque and filled with either 5 mg verapamil and 8 mg dexamethasone (study group) or 2% lidocaine (control group), and a 2.4 mA electric current was applied for 20 minutes. All patients were scheduled for 4 sessions per week for 6 weeks. Assessment before and after treatment included measurements of plaque volume and penile curvature, and pain on erection (from questionnaire). RESULTS: A total of 37 patients in the study group and 36 in the control group completed treatment courses. In the study group there were significant decreases in median plaque volume from 824 to 348 mm, and in penile curvature from 43 to 21 degrees. In the control group median volume and curvature were unchanged. The difference in results after treatment between the 2 groups was also significant. Significant pain relief occurred in both groups, transient in the control group and permanent in the study group. All patients experienced temporary erythema at the electrode site. There were no other side effects. CONCLUSIONS: Intraplaque electromotive verapamil and dexamethasone induce substantial objective improvement in Peyronie's disease compared to electromotive lidocaine administration. SN - 0022-5347 UR - https://wwww.unboundmedicine.com/medline/citation/15017231/A_prospective_randomized_study_using_transdermal_electromotive_administration_of_verapamil_and_dexamethasone_for_Peyronie's_disease_ L2 - https://www.jurology.com/doi/10.1097/01.ju.0000116450.82816.2c?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -