Tags

Type your tag names separated by a space and hit enter

Extracorporeal shock wave therapy for Peyronie's disease: exploratory meta-analysis of clinical trials.
J Urol. 2004 Feb; 171(2 Pt 1):740-5.JU

Abstract

PURPOSE

Extracorporeal shock wave therapy (ESWT) for the treatment of Peyronie's disease is still controversial. This exploratory meta-analysis of published studies in the international literature investigates its therapeutic effects.

MATERIALS AND METHODS

The treatment outcomes from 17 study groups identified by a computerized literature search were compared with natural history outcomes and data from control groups from 2 controlled ESWT studies. An exploratory meta-analysis was performed because a methodologically sound meta-analysis lege artis did not appear appropriate, since treated groups differ considerably in structure, the selection of outcome measures is inconsistent and measurement is not standardized.

RESULTS

ESWT seems to have an effect on penile pain during erection and on the improvement of sexual function. Pain seems to resolve faster after ESWT than during the course of the natural history. The effect on plaque size and penile curvature is less impressive.

CONCLUSIONS

ESWT in Peyronie's disease at least seems to be effective in regard to penile pain and sexual function compared to natural history. Deducing from these data the effect on plaque size and curvature remains questionable. However, ESWT is not an evidence based therapy at present. A controlled (preferably pairwise matched), single blind, multicenter study with careful, detailed documentation of disease symptoms before intervention and of outcomes is required to evaluate the real effect of ESWT.

Authors+Show Affiliations

Department of Urology, Justus Leibig University, Giessen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

14713800

Citation

Hauck, Ekkehard W., et al. "Extracorporeal Shock Wave Therapy for Peyronie's Disease: Exploratory Meta-analysis of Clinical Trials." The Journal of Urology, vol. 171, no. 2 Pt 1, 2004, pp. 740-5.
Hauck EW, Mueller UO, Bschleipfer T, et al. Extracorporeal shock wave therapy for Peyronie's disease: exploratory meta-analysis of clinical trials. J Urol. 2004;171(2 Pt 1):740-5.
Hauck, E. W., Mueller, U. O., Bschleipfer, T., Schmelz, H. U., Diemer, T., & Weidner, W. (2004). Extracorporeal shock wave therapy for Peyronie's disease: exploratory meta-analysis of clinical trials. The Journal of Urology, 171(2 Pt 1), 740-5.
Hauck EW, et al. Extracorporeal Shock Wave Therapy for Peyronie's Disease: Exploratory Meta-analysis of Clinical Trials. J Urol. 2004;171(2 Pt 1):740-5. PubMed PMID: 14713800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extracorporeal shock wave therapy for Peyronie's disease: exploratory meta-analysis of clinical trials. AU - Hauck,Ekkehard W, AU - Mueller,Ulrich O, AU - Bschleipfer,Thomas, AU - Schmelz,Hans U, AU - Diemer,Thorten, AU - Weidner,Wolfgang, PY - 2004/1/10/pubmed PY - 2004/2/27/medline PY - 2004/1/10/entrez SP - 740 EP - 5 JF - The Journal of urology JO - J Urol VL - 171 IS - 2 Pt 1 N2 - PURPOSE: Extracorporeal shock wave therapy (ESWT) for the treatment of Peyronie's disease is still controversial. This exploratory meta-analysis of published studies in the international literature investigates its therapeutic effects. MATERIALS AND METHODS: The treatment outcomes from 17 study groups identified by a computerized literature search were compared with natural history outcomes and data from control groups from 2 controlled ESWT studies. An exploratory meta-analysis was performed because a methodologically sound meta-analysis lege artis did not appear appropriate, since treated groups differ considerably in structure, the selection of outcome measures is inconsistent and measurement is not standardized. RESULTS: ESWT seems to have an effect on penile pain during erection and on the improvement of sexual function. Pain seems to resolve faster after ESWT than during the course of the natural history. The effect on plaque size and penile curvature is less impressive. CONCLUSIONS: ESWT in Peyronie's disease at least seems to be effective in regard to penile pain and sexual function compared to natural history. Deducing from these data the effect on plaque size and curvature remains questionable. However, ESWT is not an evidence based therapy at present. A controlled (preferably pairwise matched), single blind, multicenter study with careful, detailed documentation of disease symptoms before intervention and of outcomes is required to evaluate the real effect of ESWT. SN - 0022-5347 UR - https://wwww.unboundmedicine.com/medline/citation/14713800/Extracorporeal_shock_wave_therapy_for_Peyronie's_disease:_exploratory_meta_analysis_of_clinical_trials_ DB - PRIME DP - Unbound Medicine ER -