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Effect of physostigmine and gastric lavage in a Datura stramonium-induced anticholinergic poisoning epidemic.
Am J Emerg Med. 2003 Jul; 21(4):316-7.AJ

Abstract

This study examines the impact of the administration of physostigmine and of nasogastric evacuation of Jimsonweed seeds on intensive-care unit (ICU) use and the length of stay in the hospital after Jimsonweed poisoning. Clinical data for this retrospective study were gathered from records of consecutive patients treated for Jimsonweed poisoning from September to November 1997. Descriptive statistics, Fisher's exact test, and Student t-test were used to analyze important clinical and sociodemographic variables. There were 17 victims of the Jimsonweed ingestion epidemic, all of whom presented with an anticholinergic toxidrome 3 to 9 hours after ingestion. Reported quantities of seed ingestion ranged from a low of 7 seeds to as high as 200 seeds. Altered mentation, manifested by combative behavior, necessitated admission of 13 patients to the ICU. The administration of physostigmine did not reduce admissions to the ICU (P = 0.54) or reduce length of stay in the hospital (P = 0.45) compared with the use of benzodiazepines alone. Nasogastric lavage was performed in 14 (82%) and seeds were recovered in 8 (57%) of those lavaged. The successful removal of Jimsonweed seeds did not decrease ICU use rates (P = 0.68) or shorten length of stay in the hospital compared with not recovering seeds (P = 0.85). The use of physostigmine and the successful nasogastric lavage of Jimsonweed seeds did not result in decreased intensive-care use or shorter length of stay in the hospital for Jimsonweed-induced anticholinergic toxicity.

Authors+Show Affiliations

Department of Emergency Medicine, St. Luke's Hospital, Bethlehem, PA 18015, USA. salenp@sihn.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12898490

Citation

Salen, Philip, et al. "Effect of Physostigmine and Gastric Lavage in a Datura Stramonium-induced Anticholinergic Poisoning Epidemic." The American Journal of Emergency Medicine, vol. 21, no. 4, 2003, pp. 316-7.
Salen P, Shih R, Sierzenski P, et al. Effect of physostigmine and gastric lavage in a Datura stramonium-induced anticholinergic poisoning epidemic. Am J Emerg Med. 2003;21(4):316-7.
Salen, P., Shih, R., Sierzenski, P., & Reed, J. (2003). Effect of physostigmine and gastric lavage in a Datura stramonium-induced anticholinergic poisoning epidemic. The American Journal of Emergency Medicine, 21(4), 316-7.
Salen P, et al. Effect of Physostigmine and Gastric Lavage in a Datura Stramonium-induced Anticholinergic Poisoning Epidemic. Am J Emerg Med. 2003;21(4):316-7. PubMed PMID: 12898490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of physostigmine and gastric lavage in a Datura stramonium-induced anticholinergic poisoning epidemic. AU - Salen,Philip, AU - Shih,Richard, AU - Sierzenski,Paul, AU - Reed,James, PY - 2003/8/5/pubmed PY - 2003/9/11/medline PY - 2003/8/5/entrez SP - 316 EP - 7 JF - The American journal of emergency medicine JO - Am J Emerg Med VL - 21 IS - 4 N2 - This study examines the impact of the administration of physostigmine and of nasogastric evacuation of Jimsonweed seeds on intensive-care unit (ICU) use and the length of stay in the hospital after Jimsonweed poisoning. Clinical data for this retrospective study were gathered from records of consecutive patients treated for Jimsonweed poisoning from September to November 1997. Descriptive statistics, Fisher's exact test, and Student t-test were used to analyze important clinical and sociodemographic variables. There were 17 victims of the Jimsonweed ingestion epidemic, all of whom presented with an anticholinergic toxidrome 3 to 9 hours after ingestion. Reported quantities of seed ingestion ranged from a low of 7 seeds to as high as 200 seeds. Altered mentation, manifested by combative behavior, necessitated admission of 13 patients to the ICU. The administration of physostigmine did not reduce admissions to the ICU (P = 0.54) or reduce length of stay in the hospital (P = 0.45) compared with the use of benzodiazepines alone. Nasogastric lavage was performed in 14 (82%) and seeds were recovered in 8 (57%) of those lavaged. The successful removal of Jimsonweed seeds did not decrease ICU use rates (P = 0.68) or shorten length of stay in the hospital compared with not recovering seeds (P = 0.85). The use of physostigmine and the successful nasogastric lavage of Jimsonweed seeds did not result in decreased intensive-care use or shorter length of stay in the hospital for Jimsonweed-induced anticholinergic toxicity. SN - 0735-6757 UR - https://wwww.unboundmedicine.com/medline/citation/12898490/Effect_of_physostigmine_and_gastric_lavage_in_a_Datura_stramonium_induced_anticholinergic_poisoning_epidemic_ DB - PRIME DP - Unbound Medicine ER -